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Christopher Lipinski
Christopher Lipinski
Scientific Advisor Melior Discovery
Geverifieerd e-mailadres voor meliordiscovery.com - Homepage
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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
CA Lipinski, F Lombardo, BW Dominy, PJ Feeney
Adv. Drug Deliv. Rev 46 (1-3), 3, 2001
28017*2001
Experimental and Computational Approaches to Estimate Solubility and Permeability in Drug Discovery and Development Settings
CA Lipinski, F Lombardo, BW Dominy, PJ Feeney
Advanced drug delivery reviews 23, 3-25, 1997
27996*1997
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
CA Lipinski, F Lombardo, BW Dominy, PJ Feeney
Advanced drug delivery reviews 64, 4-17, 2012
279722012
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
CA Lipinski, F Lombardo, BW Dominy, PJ Feeney
Advanced drug delivery reviews 46 (1-3), 3-26, 2001
27972*2001
Lead-and drug-like compounds: the rule-of-five revolution
CA Lipinski
Drug discovery today: Technologies 1 (4), 337-341, 2004
52832004
Drug-like properties and the causes of poor solubility and poor permeability
CA Lipinski
Journal of pharmacological and toxicological methods 44 (1), 235-249, 2000
43032000
Navigating chemical space for biology and medicine
C Lipinski, A Hopkins
Nature 432 (7019), 855-861, 2004
12252004
Poor aqueous solubility—an industry wide problem in drug discovery
C Lipinski
Am. Pharm. Rev 5 (3), 82-85, 2002
11072002
Rule of five in 2015 and beyond: Target and ligand structural limitations, ligand chemistry structure and drug discovery project decisions
CA Lipinski
Advanced drug delivery reviews 101, 34-41, 2016
4812016
Avoiding investment in doomed drugs
CA Lipinski
Curr Drug Discov 1, 17-19, 2001
2232001
Chris Lipinski discusses life and chemistry after the Rule of Five
CA Lipinski
Drug discovery today 8 (1), 12-16, 2003
2172003
Bioisosterism in Drug Design
CA Lipinski
Annual Reports in Medicinal Chemistry 21, 283-291, 1986
2051986
Quantitative Structure−Activity Relationships among Macrolide Antibacterial Agents:  In Vitro and in Vivo Potency against Pasteurella multocida
JW McFarland, CM Berger, SA Froshauer, SF Hayashi, SJ Hecker, ...
Journal of medicinal chemistry 40 (9), 1340-1346, 1997
1771997
A crowdsourcing evaluation of the NIH chemical probes
TI Oprea, CG Bologa, S Boyer, RF Curpan, RC Glen, AL Hopkins, ...
Nature chemical biology 5 (7), 441-447, 2009
1392009
Badapple: promiscuity patterns from noisy evidence
JJ Yang, O Ursu, CA Lipinski, LA Sklar, TI Oprea, CG Bologa
Journal of cheminformatics 8, 1-14, 2016
932016
Analysis and hit filtering of a very large library of compounds screened against Mycobacterium tuberculosis
S Ekins, T Kaneko, CA Lipinski, J Bradford, K Dole, A Spektor, K Gregory, ...
Molecular bioSystems 6 (11), 2316-2324, 2010
822010
Polar molecular surface properties predict the intestinal absorption of drugs in humans
CA Lipinski, F Lombardo, BW Dominy, PJ Feeney
Adv. Drug Delivery Rev 46 (1-3), 3-26, 2001
822001
Synthesis and antitubercular activity of 7-(R)-and 7-(S)-methyl-2-nitro-6-(S)-(4-(trifluoromethoxy) benzyloxy)-6, 7-dihydro-5H-imidazo [2, 1-b][1, 3] oxazines, analogues of PA-824
X Li, UH Manjunatha, MB Goodwin, JE Knox, CA Lipinski, TH Keller, ...
Bioorganic & medicinal chemistry letters 18 (7), 2256-2262, 2008
782008
High throughput sonication: evaluation for compound solubilization
K Oldenburg, D Pooler, K Scudder, C Lipinski, M Kelly
Combinatorial chemistry & high throughput screening 8 (6), 499-512, 2005
742005
Medicinal chemistry of aldose reductase inhibitors
ER Larson, CA Lipinski, R Sarges
Medicinal research reviews 8 (2), 159-186, 1988
581988
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Artikelen 1–20