Crystal structure of the cofactor-binding domain of the human phase II drug-metabolism enzyme UDP-glucuronosyltransferase 2B7 MJ Miley, AK Zielinska, JE Keenan, SM Bratton, A Radominska-Pandya, ... Journal of molecular biology 369 (2), 498-511, 2007 | 231 | 2007 |
Cytochrome P450-mediated oxidative metabolism of abused synthetic cannabinoids found in K2/Spice: identification of novel cannabinoid receptor ligands KC Chimalakonda, KA Seely, SM Bratton, LK Brents, CL Moran, ... Drug metabolism and disposition 40 (11), 2174-2184, 2012 | 220 | 2012 |
Characterization of human hepatic and extrahepatic UDP-glucuronosyltransferase enzymes involved in the metabolism of classic cannabinoids A Mazur, CF Lichti, PL Prather, AK Zielinska, SM Bratton, ... Drug Metabolism and Disposition 37 (7), 1496-1504, 2009 | 166 | 2009 |
Conjugation of synthetic cannabinoids JWH-018 and JWH-073, metabolites by human UDP-glucuronosyltransferases KC Chimalakonda, SM Bratton, VH Le, KH Yiew, A Dineva, CL Moran, ... Drug metabolism and disposition 39 (10), 1967-1976, 2011 | 113 | 2011 |
The crystal structure of human UDP-glucuronosyltransferase 2B7 C-terminal end is the first mammalian UGT target to be revealed: the significance for human UGTs from both the 1A … A Radominska-Pandya, SM Bratton, MR Redinbo, MJ Miley Drug metabolism reviews 42 (1), 133-144, 2010 | 91 | 2010 |
Ethylenediamine functionalized-single-walled nanotube (f-SWNT)-assisted in vitro delivery of the oncogene suppressor p53 gene to breast cancer MCF-7 cells A Karmakar, SM Bratton, E Dervishi, A Ghosh, M Mahmood, Y Xu, ... International journal of nanomedicine, 1045-1055, 2011 | 84 | 2011 |
A historical overview of the heterologous expression of mammalian UDP-glucuronosyltransferase isoforms over the past twenty years A Radominska-Pandya, S Bratton, JM Little Current drug metabolism 6 (2), 141-160, 2005 | 80 | 2005 |
Human UDP-glucuronosyltransferase 1A5: identification, expression, and activity M Finel, X Li, D Gardner-Stephen, S Bratton, PI Mackenzie, ... Journal of Pharmacology and Experimental Therapeutics 315 (3), 1143-1149, 2005 | 79 | 2005 |
Lithocholic acid decreases expression of UGT2B7 in Caco-2 cells: a potential role for a negative farnesoid X receptor response element Y Lu, JM Heydel, X Li, S Bratton, T Lindblom, A Radominska-Pandya Drug metabolism and disposition 33 (7), 937-946, 2005 | 71 | 2005 |
Glucuronidation of oxidized fatty acids and prostaglandins B1 and E2 by human hepatic and recombinant UDP-glucuronosyltransferases JM Little, M Kurkela, J Sonka, S Jäntti, R Ketola, S Bratton, M Finel, ... Journal of lipid research 45 (9), 1694-1703, 2004 | 67 | 2004 |
Natural prenylated resveratrol analogs arachidin-1 and-3 demonstrate improved glucuronidation profiles and have affinity for cannabinoid receptors LK Brents, F Medina-Bolivar, KA Seely, V Nair, SM Bratton, ... Xenobiotica 42 (2), 139-156, 2012 | 57 | 2012 |
Glucuronidation of monohydroxylated warfarin metabolites by human liver microsomes and human recombinant UDP-glucuronosyltransferases A Zielinska, CF Lichti, S Bratton, NC Mitchell, A Gallus-Zawada, VH Le, ... Journal of Pharmacology and Experimental Therapeutics 324 (1), 139-148, 2008 | 53 | 2008 |
Phenylalanine 90 and 93 are localized within the phenol binding site of human UDP-glucuronosyltransferase 1A10 as determined by photoaffinity labeling, mass spectrometry, and … Y Xiong, D Bernardi, S Bratton, MD Ward, E Battaglia, M Finel, RR Drake, ... Biochemistry 45 (7), 2322-2332, 2006 | 53 | 2006 |
Phenylalanine90 and phenylalanine93 are crucial amino acids within the estrogen binding site of the human UDP-glucuronosyltransferase 1A10 A Starlard-Davenport, Y Xiong, S Bratton, A Gallus-Zawada, M Finel, ... Steroids 72 (1), 85-94, 2007 | 45 | 2007 |
Role of human UDP-glucuronosyltransferases in the biotransformation of the triazoloacridinone and imidazoacridinone antitumor agents C-1305 and C-1311: highly selective … B Fedejko-Kap, SM Bratton, M Finel, A Radominska-Pandya, Z Mazerska Drug Metabolism and Disposition 40 (9), 1736-1743, 2012 | 26 | 2012 |
The first aspartic acid of the DQxD motif for human UDP-glucuronosyltransferase 1A10 interacts with UDP-glucuronic acid during catalysis Y Xiong, AS Patana, MJ Miley, AK Zielinska, SM Bratton, GP Miller, ... Drug metabolism and disposition 36 (3), 517-522, 2008 | 22 | 2008 |
Human UGT1A8 and UGT1A10 mRNA are expressed in primary human hepatocytes X Li, S Bratton, A Radominska-Pandya Drug metabolism and pharmacokinetics 22 (3), 152-161, 2007 | 20 | 2007 |
Effect of retinoids on UDP-glucuronosyltransferase 2B7 mRNA expression in Caco-2 cells Y Lu, S Bratton, JM Heydel, A Radominska-Pandya Drug metabolism and pharmacokinetics 23 (5), 364-372, 2008 | 18 | 2008 |
Analysis of R-and S-hydroxywarfarin glucuronidation catalyzed by human liver microsomes and recombinant UDP-glucuronosyltransferases SM Bratton, CM Mosher, F Khallouki, M Finel, JH Moran, ... Journal of Pharmacology and Experimental Therapeutics 340 (1), 46-55, 2012 | 16 | 2012 |
Conjugation of Synthetic Cannabinoids, JWH-018 [Naphthalen-1-yl-(1-pentylindol-3-yl) methanone] and JWH-073 [naphthalen-1-yl-(1-butylindol-3-yl) methanone], Metabolites by … KC Chimalakonda, SM Bratton, VH Le, KHN Yiew, A Dineva, CL Moran, ... Drug Metabolism and Disposition, 2011 | 5 | 2011 |