Nuclear-import receptors reverse aberrant phase transitions of RNA-binding proteins with prion-like domains L Guo, HJ Kim, H Wang, J Monaghan, F Freyermuth, JC Sung, ... Cell 173 (3), 677-692. e20, 2018 | 418 | 2018 |
Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104 SN Gates, AL Yokom, JB Lin, ME Jackrel, AN Rizo, NM Kendsersky, ... Science 357 (6348), 273-279, 2017 | 256 | 2017 |
Operational plasticity enables hsp104 to disaggregate diverse amyloid and nonamyloid clients ME DeSantis, EH Leung, EA Sweeny, ME Jackrel, M Cushman-Nick, ... Cell 151 (4), 778-793, 2012 | 195 | 2012 |
A synergistic small-molecule combination directly eradicates diverse prion strain structures BE Roberts, ML Duennwald, H Wang, C Chung, NP Lopreiato, ... Nature chemical biology 5 (12), 936-946, 2009 | 115 | 2009 |
The Hsp104 N-terminal domain enables disaggregase plasticity and potentiation EA Sweeny, ME Jackrel, MS Go, MA Sochor, BM Razzo, ME DeSantis, ... Molecular cell 57 (5), 836-849, 2015 | 102 | 2015 |
Glyceraldehyde-3-phosphate dehydrogenase is a chaperone that allocates labile heme in cells EA Sweeny, AB Singh, R Chakravarti, O Martinez-Guzman, A Saini, ... Journal of Biological Chemistry 293 (37), 14557-14568, 2018 | 100 | 2018 |
Mechanistic and structural insights into the prion-disaggregase activity of Hsp104 EA Sweeny, J Shorter Journal of molecular biology 428 (9), 1870-1885, 2016 | 98 | 2016 |
Formation of Nitrogenase NifDK Tetramers in the Mitochondria of Saccharomyces cerevisiae S Burén, EM Young, EA Sweeny, G Lopez-Torrejón, M Veldhuizen, ... ACS Synthetic Biology 6 (6), 1043-1055, 2017 | 79 | 2017 |
Hsp90 chaperones hemoglobin maturation in erythroid and nonerythroid cells A Ghosh, G Garee, EA Sweeny, Y Nakamura, DJ Stuehr Proceedings of the National Academy of Sciences 115 (6), E1117-E1126, 2018 | 55 | 2018 |
Conserved distal loop residues in the Hsp104 and ClpB middle domain contact nucleotide-binding domain 2 and enable Hsp70-dependent protein disaggregation ME DeSantis, EA Sweeny, D Snead, EH Leung, MS Go, K Gupta, ... Journal of Biological Chemistry 289 (2), 848-867, 2014 | 53 | 2014 |
GAPDH delivers heme to soluble guanylyl cyclase Y Dai, EA Sweeny, S Schlanger, A Ghosh, DJ Stuehr Journal of Biological Chemistry 295 (24), 8145-8154, 2020 | 50 | 2020 |
Prion proteostasis: Hsp104 meets its supporting cast EA Sweeny, J Shorter Prion 2 (4), 135-140, 2008 | 50* | 2008 |
Mining disaggregase sequence space to safely counter TDP-43, FUS, and α-synuclein proteotoxicity A Tariq, JB Lin, ME Jackrel, CD Hesketh, PJ Carman, KL Mack, ... Cell reports 28 (8), 2080-2095. e6, 2019 | 44 | 2019 |
Purification of hsp104, a protein disaggregase EA Sweeny, ME DeSantis, J Shorter JoVE (Journal of Visualized Experiments), e3190, 2011 | 28 | 2011 |
GAPDH is involved in the heme-maturation of myoglobin and hemoglobin B Tupta, E Stuehr, MP Sumi, EA Sweeny, B Smith, DJ Stuehr, A Ghosh FASEB journal: official publication of the Federation of American Societies …, 2022 | 24 | 2022 |
Structural and mechanistic insights into Hsp104 function revealed by synchrotron X-ray footprinting EA Sweeny, A Tariq, E Gurpinar, MS Go, MA Sochor, ZY Kan, L Mayne, ... Journal of Biological Chemistry 295 (6), 1517-1538, 2020 | 21 | 2020 |
Hsp104 and potentiated variants can operate as distinct nonprocessive translocases CL Durie, JB Lin, NW Scull, KL Mack, ME Jackrel, EA Sweeny, ... Biophysical Journal 116 (10), 1856-1872, 2019 | 19 | 2019 |
Dynamic regulation of NADPH oxidase 5 by intracellular heme levels and cellular chaperones EA Sweeny, S Schlanger, DJ Stuehr Redox biology 36, 101656, 2020 | 14 | 2020 |
Avidity for polypeptide binding by nucleotide-bound Hsp104 structures CL Weaver, EC Duran, KL Mack, JB Lin, ME Jackrel, EA Sweeny, ... Biochemistry 56 (15), 2071-2075, 2017 | 13 | 2017 |
New roles for GAPDH, Hsp90, and NO in regulating heme allocation and hemeprotein function in mammals DJ Stuehr, Y Dai, P Biswas, EA Sweeny, A Ghosh Biological chemistry 403 (11-12), 1005-1015, 2022 | 11 | 2022 |