| Ratiometric biosensors based on dimerization-dependent fluorescent protein exchange Y Ding, J Li, JR Enterina, Y Shen, I Zhang, PH Tewson, GCH Mo, J Zhang, ... Nature methods 12 (3), 195-198, 2015 | 157 | 2015 |
| Cilia have high cAMP levels that are inhibited by Sonic Hedgehog-regulated calcium dynamics BS Moore, AN Stepanchick, PH Tewson, CM Hartle, J Zhang, AM Quinn, ... Proceedings of the National Academy of Sciences 113 (46), 13069-13074, 2016 | 113 | 2016 |
| New DAG and cAMP sensors optimized for live-cell assays in automated laboratories PH Tewson, S Martinka, NC Shaner, TE Hughes, AM Quinn Journal of biomolecular screening 21 (3), 298-305, 2016 | 108 | 2016 |
| Diazoxide-unresponsive congenital hyperinsulinism in children with dominant mutations of the β-cell sulfonylurea receptor SUR1 CM MacMullen, Q Zhou, KE Snider, PH Tewson, SA Becker, AR Aziz, ... Diabetes 60 (6), 1797-1804, 2011 | 79 | 2011 |
| Simultaneous Detection of Ca2+ and Diacylglycerol Signaling in Living Cells P Tewson, M Westenberg, Y Zhao, RE Campbell, AM Quinn, TE Hughes Public Library of Science 7 (8), e42791, 2012 | 72 | 2012 |
| Chicken protocadherin-1 functions to localize neural crest cells to the dorsal root ganglia during PNS formation J Bononi, A Cole, P Tewson, A Schumacher, R Bradley Mechanisms of development 125 (11-12), 1033-1047, 2008 | 42 | 2008 |
| Analyzing kinetic signaling data for G-protein-coupled receptors SRJ Hoare, PH Tewson, AM Quinn, TE Hughes, LJ Bridge Scientific reports 10 (1), 12263, 2020 | 39 | 2020 |
| A multiplexed fluorescent assay for independent second-messenger systems: decoding GPCR activation in living cells PH Tewson, AM Quinn, TE Hughes Journal of biomolecular screening 18 (7), 797-806, 2013 | 35 | 2013 |
| N-terminal transmembrane domain of SUR1 controls gating of Kir6.2 by modulating channel sensitivity to PIP2 EB Pratt, P Tewson, CE Bruederle, WR Skach, SL Shyng Journal of General Physiology 137 (3), 299-314, 2011 | 29 | 2011 |
| A kinetic method for measuring agonist efficacy and ligand bias using high resolution biosensors and a kinetic data analysis framework SRJ Hoare, PH Tewson, AM Quinn, TE Hughes Scientific Reports 10 (1), 1766, 2020 | 24 | 2020 |
| PKC-dependent phosphorylation of the H1 histamine receptor modulates TRPC6 activity X Chen, C Egly, AM Riley, W Li, P Tewson, TE Hughes, AM Quinn, ... Cells 3 (2), 247-257, 2014 | 20 | 2014 |
| Quantifying the kinetics of signaling and arrestin recruitment by nervous system G-protein coupled receptors SRJ Hoare, PH Tewson, S Sachdev, M Connor, TE Hughes, AM Quinn Frontiers in Cellular Neuroscience 15, 814547, 2022 | 11 | 2022 |
| Assay for detecting Gαi-mediated decreases in cAMP in living cells P Tewson, S Martinka, N Shaner, C Berlot, AM Quinn, T Hughes SLAS DISCOVERY: Advancing Life Sciences R&D 23 (9), 898-906, 2018 | 11 | 2018 |
| Characterization and functional restoration of a potassium channel Kir6. 2 pore mutation identified in congenital hyperinsulinism JD Bushman, JW Gay, P Tewson, CA Stanley, SL Shyng Journal of biological chemistry 285 (9), 6012-6023, 2010 | 8 | 2010 |
| Genetically encoded fluorescent sensors for detecting intracellular signalling through diacylglycerol pathways TE Hughes, PH Tewson, AM Quinn US Patent 9,547,017, 2017 | 3 | 2017 |
| Diazoxide-unresponsive congenital hyperinsulinism in children with dominant mutations of the b-cell sulfo-nylurea receptor SUR1. Diabetes 2011; 60: 1797–1804 CM Macmullen, Q Zhou, KE Snider, PH Tewson, SA Becker, AR Aziz, ... | 3 | 2011 |
| Real-Time Detection of Gs and Gi Signalling in Living Cells P Tewson, S Martinka, S Tillo, T Hughes, AM Quinn, C Peters | 1 | 2016 |
| Genetically encoded fluorescent sensors for detecting ligand bias and intracellular signaling through cAMP pathways TE Hughes, PH Tewson, AM Quinn | 1 | 2015 |
| GENETICALLY ENCODED FLUORESCENT SENSORS FOR DETECTING LIGAND BIAS AND INTRACELLULAR SIGNALING THROUGH cAMP PATHWAYS TE Hughes, PH Tewson, AM Quinn US Patent App. 17/824,643, 2022 | | 2022 |
| Biosensors for detecting arrestin signaling T Hughes, P Tewson US Patent App. 17/262,782, 2021 | | 2021 |
Thomas E. HughesCSO, Montana MolecularVerified email at montanamolecular.com
