Bin Fang
Bin Fang
Novartis Institutes for BioMedical Research
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Discrete functions of nuclear receptor Rev-erbα couple metabolism to the clock
Y Zhang, B Fang, MJ Emmett, M Damle, Z Sun, D Feng, SM Armour, ...
Science 348 (6242), 1488-1492, 2015
Deacetylase-independent function of HDAC3 in transcription and metabolism requires nuclear receptor corepressor
Z Sun, D Feng, B Fang, SE Mullican, SH You, HW Lim, LJ Everett, ...
Molecular cell 52 (6), 769-782, 2013
Circadian enhancers coordinate multiple phases of rhythmic gene transcription in vivo
B Fang, LJ Everett, J Jager, E Briggs, SM Armour, D Feng, A Roy, ...
Cell 159 (5), 1140-1152, 2014
Diet-induced circadian enhancer remodeling synchronizes opposing hepatic lipid metabolic processes
D Guan, Y Xiong, PC Borck, C Jang, PT Doulias, R Papazyan, B Fang, ...
Cell 174 (4), 831-842. e12, 2018
Genetic Variation Determines PPARγ Function and Anti-diabetic Drug Response In Vivo
LMA Soccio RE, Chen ER, Rajapurkar SR, Safabakhsh P, Marinis JM, Dispirito ...
cell 162 (1), 33-44, 2015
Identification of a binding motif specific to HNF4 by comparative analysis of multiple nuclear receptors
B Fang, D Mane-Padros, E Bolotin, T Jiang, FM Sladek
Nucleic Acids Research 40 (12), 5343-5356, 2012
Dissociation of muscle insulin sensitivity from exercise endurance in mice by HDAC3 depletion
S Hong, W Zhou, B Fang, W Lu, E Loro, M Damle, G Ding, J Jager, ...
Nature Medicine, 2016
Behavioral changes and dopaminergic dysregulation in mice lacking the nuclear receptor Rev-erbα
J Jager, WT O'Brien, J Manlove, EN Krizman, B Fang, Z Gerhart-Hines, ...
Molecular endocrinology 28 (4), 490-498, 2014
Tropifexor‐mediated abrogation of steatohepatitis and fibrosis is associated with the antioxidative gene expression profile in rodents
ED Hernandez, L Zheng, Y Kim, B Fang, B Liu, RA Valdez, WF Dietrich, ...
Hepatology communications 3 (8), 1085-1097, 2019
Stimulus-cleavable chemistry in the field of controlled drug delivery
Y Xue, H Bai, B Peng, B Fang, J Baell, L Li, W Huang, NH Voelcker
Chemical Society Reviews 50 (8), 4872-4931, 2021
Structural and kinetic analysis of caspase-3 reveals role for s5 binding site in substrate recognition
B Fang, PI Boross, J Tozser, IT Weber
Journal of molecular biology 360 (3), 654-666, 2006
Plasticity of S2–S4 specificity pockets of executioner caspase‐7 revealed by structural and kinetic analysis
J Agniswamy, B Fang, IT Weber
The FEBS Journal 274 (18), 4752-4765, 2007
The hepatic circadian clock fine-tunes the lipogenic response to feeding through RORα/γ
Y Zhang, R Papazyan, M Damle, B Fang, J Jager, D Feng, LC Peed, ...
Genes & Development 31 (12), 1202-1211, 2017
Differential effects of hepatocyte nuclear factor 4α isoforms on tumor growth and T-cell factor 4/AP-1 interactions in human colorectal cancer cells
LM Vuong, K Chellappa, JM Dhahbi, JR Deans, B Fang, E Bolotin, ...
Molecular and cellular biology 35 (20), 3471-3490, 2015
HNF6 and Rev-erbα integrate hepatic lipid metabolism by overlapping and distinct transcriptional mechanisms
Y Zhang, B Fang, M Damle, D Guan, Z Li, YH Kim, M Gannon, MA Lazar
Genes & development 30 (14), 1636-1644, 2016
Structural basis for executioner caspase recognition of P5 position in substrates
G Fu, AA Chumanevich, J Agniswamy, B Fang, RW Harrison, IT Weber
Apoptosis 13 (11), 1291-1302, 2008
The nuclear receptor Rev-erbα regulates adipose tissue-specific FGF21 signaling
J Jager, F Wang, B Fang, HW Lim, LC Peed, DJ Steger, KJ Won, ...
Journal of Biological Chemistry 291 (20), 10867-10875, 2016
Caspase-3 binds diverse P4 residues in peptides as revealed by crystallography and structural modeling
B Fang, G Fu, J Agniswamy, RW Harrison, IT Weber
Apoptosis 14 (5), 741-752, 2009
Genetic backgrounds determine brown remodeling of white fat in rodents
G Ferrannini, M Namwanje, B Fang, M Damle, D Li, Q Liu, MA Lazar, ...
Molecular metabolism 5 (10), 948-958, 2016
Conformational similarity in the activation of caspase-3 and-7 revealed by the unliganded and inhibited structures of caspase-7
J Agniswamy, B Fang, IT Weber
Apoptosis 14 (10), 1135-1144, 2009
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