Nicola J Smith
Nicola J Smith
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International Union of Pharmacology. LXXI. Free fatty acid receptors FFA1,-2, and-3: pharmacology and pathophysiological functions
LA Stoddart, NJ Smith, G Milligan
Pharmacological reviews 60 (4), 405-417, 2008
Allostery at G protein-coupled receptor homo-and heteromers: uncharted pharmacological landscapes
NJ Smith, G Milligan
Pharmacological reviews 62 (4), 701-725, 2010
Deconvolution of complex G protein–coupled receptor signaling in live cells using dynamic mass redistribution measurements
R Schröder, N Janssen, J Schmidt, A Kebig, N Merten, S Hennen, ...
Nature biotechnology 28 (9), 943-949, 2010
Allosteric modulation of heterodimeric G-protein-coupled receptors
G Milligan, NJ Smith
Trends in pharmacological sciences 28 (12), 615-620, 2007
Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3
J Schmidt, NJ Smith, E Christiansen, IG Tikhonova, M Grundmann, ...
Journal of Biological Chemistry 286 (12), 10628-10640, 2011
Angiotensin1‐9 antagonises pro‐hypertrophic signalling in cardiomyocytes via the angiotensin type 2 receptor
M Flores‐Muñoz, NJ Smith, C Haggerty, G Milligan, SA Nicklin
The journal of Physiology 589 (4), 939-951, 2011
The action and mode of binding of thiazolidinedione ligands at free fatty acid receptor 1
NJ Smith, LA Stoddart, NM Devine, L Jenkins, G Milligan
Journal of Biological Chemistry 284 (26), 17527-17539, 2009
Conserved polar residues in transmembrane domains V, VI, and VII of free fatty acid receptor 2 and free fatty acid receptor 3 are required for the binding and function of short …
LA Stoddart, NJ Smith, L Jenkins, AJ Brown, G Milligan
Journal of Biological Chemistry 283 (47), 32913-32924, 2008
Identification of novel species-selective agonists of the G-protein-coupled receptor GPR35 that promote recruitment of β-arrestin-2 and activate Gα13
L Jenkins, J Brea, NJ Smith, BD Hudson, G Reilly, NJ Bryant, M Castro, ...
Biochemical Journal 432 (3), 451-459, 2010
Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator
NJ Smith, RJ Ward, LA Stoddart, BD Hudson, E Kostenis, T Ulven, ...
Molecular pharmacology 80 (1), 163-173, 2011
When simple agonism is not enough: emerging modalities of GPCR ligands
NJ Smith, KA Bennett, G Milligan
Molecular and cellular endocrinology 331 (2), 241-247, 2011
Ablation of cardiac myosin binding protein-C disrupts the super-relaxed state of myosin in murine cardiomyocytes
JW McNamara, A Li, NJ Smith, S Lal, RM Graham, KB Kooiker, ...
Journal of molecular and cellular cardiology 94, 65-71, 2016
What’s new in the renin-angiotensin system?
NJ Smith, HW Chan, JE Osborne, WG Thomas, RD Hannan
Cellular and Molecular Life Sciences CMLS 61 (21), 2695-2703, 2004
Agonism and allosterism: the pharmacology of the free fatty acid receptors FFA2 and FFA3
G Milligan, LA Stoddart, NJ Smith
British journal of pharmacology 158 (1), 146-153, 2009
Identifying ligands at orphan GPCRs: current status using structure‐based approaches
T Ngo, I Kufareva, JLJ Coleman, RM Graham, R Abagyan, NJ Smith
British journal of pharmacology 173 (20), 2934-2951, 2016
Signal switching, crosstalk, and arrestin scaffolds: novel G protein–coupled receptor signaling in cardiovascular disease
NJ Smith, LM Luttrell
Hypertension 48 (2), 173-179, 2006
Experimental challenges to targeting poorly characterized GPCRs: uncovering the therapeutic potential for free fatty acid receptors
BD Hudson, NJ Smith, G Milligan
Advances in pharmacology 62, 175-218, 2011
Orphan receptor ligand discovery by pickpocketing pharmacological neighbors
T Ngo, AV Ilatovskiy, AG Stewart, JLJ Coleman, FM McRobb, RP Riek, ...
Nature chemical biology 13 (2), 235-242, 2017
Tackling the EGFR in pathological tissue remodelling
HW Chan, NJ Smith, RD Hannan, WG Thomas
Pulmonary pharmacology & therapeutics 19 (1), 74-78, 2006
A molecular mechanism for sequential activation of a G protein-coupled receptor
M Grundmann, IG Tikhonova, BD Hudson, NJ Smith, K Mohr, T Ulven, ...
Cell chemical biology 23 (3), 392-403, 2016
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