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Andrew Flyak
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Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations
F Muecksch, Y Weisblum, CO Barnes, F Schmidt, D Schaefer-Babajew, ...
Immunity 54 (8), 1853-1868. e7, 2021
2312021
IL-15 regulates homeostasis and terminal maturation of NKT cells
LE Gordy, JS Bezbradica, AI Flyak, CT Spencer, A Dunkle, J Sun, ...
The Journal of Immunology 187 (12), 6335-6345, 2011
1862011
Cross-reactive and potent neutralizing antibody responses in human survivors of natural ebolavirus infection
AI Flyak, X Shen, CD Murin, HL Turner, JA David, ML Fusco, R Lampley, ...
Cell 164 (3), 392-405, 2016
1712016
Mechanism of human antibody-mediated neutralization of Marburg virus
AI Flyak, PA Ilinykh, CD Murin, T Garron, X Shen, ML Fusco, T Hashiguchi, ...
Cell 160 (5), 893-903, 2015
1562015
Isolation and characterization of broad and ultrapotent human monoclonal antibodies with therapeutic activity against chikungunya virus
SA Smith, LA Silva, JM Fox, AI Flyak, N Kose, G Sapparapu, ...
Cell host & microbe 18 (1), 86-95, 2015
1502015
Structural basis for Marburg virus neutralization by a cross-reactive human antibody
T Hashiguchi, ML Fusco, ZA Bornholdt, JE Lee, AI Flyak, R Matsuoka, ...
Cell 160 (5), 904-912, 2015
1332015
Broadly neutralizing antibodies with few somatic mutations and hepatitis C virus clearance
JR Bailey, AI Flyak, VJ Cohen, H Li, LN Wasilewski, AE Snider, S Wang, ...
JCI insight 2 (9), 2017
1262017
A “Trojan horse” bispecific-antibody strategy for broad protection against ebolaviruses
AZ Wec, EK Nyakatura, AS Herbert, KA Howell, FW Holtsberg, RR Bakken, ...
Science 354 (6310), 350-354, 2016
1252016
Host-primed Ebola virus GP exposes a hydrophobic NPC1 receptor-binding pocket, revealing a target for broadly neutralizing antibodies
ZA Bornholdt, E Ndungo, ML Fusco, S Bale, AI Flyak, JE Crowe Jr, ...
MBio 7 (1), 10.1128/mbio. 02154-15, 2016
1102016
HCV broadly neutralizing antibodies use a CDRH3 disulfide motif to recognize an E2 glycoprotein site that can be targeted for vaccine design
AI Flyak, S Ruiz, MD Colbert, T Luong, JE Crowe, JR Bailey, PJ Bjorkman
Cell host & microbe 24 (5), 703-716. e3, 2018
1072018
Structures of Ebola virus GP and sGP in complex with therapeutic antibodies
J Pallesen, CD Murin, N De Val, CA Cottrell, KM Hastie, HL Turner, ...
Nature microbiology 1 (9), 1-9, 2016
1072016
Broadly neutralizing antibody mediated clearance of human hepatitis C virus infection
VJ Kinchen, MN Zahid, AI Flyak, MG Soliman, GH Learn, S Wang, ...
Cell host & microbe 24 (5), 717-730. e5, 2018
872018
Antibody-dependent enhancement of Ebola virus infection by human antibodies isolated from survivors
NA Kuzmina, P Younan, P Gilchuk, RI Santos, AI Flyak, PA Ilinykh, ...
Cell reports 24 (7), 1802-1815. e5, 2018
842018
Therapeutic treatment of Marburg and Ravn virus infection in nonhuman primates with a human monoclonal antibody
CE Mire, JB Geisbert, V Borisevich, KA Fenton, KN Agans, AI Flyak, ...
Science translational medicine 9 (384), eaai8711, 2017
792017
Multifunctional pan-ebolavirus antibody recognizes a site of broad vulnerability on the ebolavirus glycoprotein
P Gilchuk, N Kuzmina, PA Ilinykh, K Huang, BM Gunn, A Bryan, ...
Immunity 49 (2), 363-374. e10, 2018
742018
Broadly neutralizing antibodies from human survivors target a conserved site in the Ebola virus glycoprotein HR2–MPER region
AI Flyak, N Kuzmina, CD Murin, C Bryan, E Davidson, P Gilchuk, ...
Nature microbiology 3 (6), 670-677, 2018
732018
Synergistic anti-HCV broadly neutralizing human monoclonal antibodies with independent mechanisms
MC Mankowski, VJ Kinchen, LN Wasilewski, AI Flyak, SC Ray, ...
Proceedings of the National Academy of Sciences 115 (1), E82-E91, 2018
542018
The marburgvirus-neutralizing human monoclonal antibody MR191 targets a conserved site to block virus receptor binding
LB King, ML Fusco, AI Flyak, PA Ilinykh, K Huang, B Gunn, ...
Cell host & microbe 23 (1), 101-109. e4, 2018
532018
Broadly neutralizing antibodies targeting new sites of vulnerability in hepatitis C virus E1E2
MD Colbert, AI Flyak, CO Ogega, VJ Kinchen, G Massaccesi, ...
Journal of virology 93 (14), 10.1128/jvi. 02070-18, 2019
452019
Chimeric filoviruses for identification and characterization of monoclonal antibodies
PA Ilinykh, X Shen, AI Flyak, N Kuzmina, TG Ksiazek, JE Crowe Jr, ...
Journal of virology 90 (8), 3890-3901, 2016
452016
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