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Jeffrey Toretsky
Jeffrey Toretsky
Verified email at georgetown.edu
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Year
Mutational inactivation of STAG2 causes aneuploidy in human cancer
DA Solomon, T Kim, LA Diaz-Martinez, J Fair, AG Elkahloun, BT Harris, ...
Science 333 (6045), 1039-1043, 2011
5482011
BRD–NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells
CA French, CL Ramirez, J Kolmakova, TT Hickman, MJ Cameron, ...
Oncogene 27 (15), 2237-2242, 2008
4982008
A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma
HV Erkizan, Y Kong, M Merchant, S Schlottmann, JS Barber-Rotenberg, ...
Nature medicine 15 (7), 750-756, 2009
4772009
Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90.
MV Blagosklonny, J Toretsky, S Bohen, L Neckers
Proceedings of the National Academy of Sciences 93 (16), 8379-8383, 1996
4291996
Midline Carcinoma of Children and Young Adults With NUT Rearrangement
CA French, JL Kutok, WC Faquin, JA Toretsky, CR Antonescu, CA Griffin, ...
Journal of clinical oncology 22 (20), 4135-4139, 2004
4062004
Downstream of mutant KRAS, the transcription regulator YAP is essential for neoplastic progression to pancreatic ductal adenocarcinoma
W Zhang, N Nandakumar, Y Shi, M Manzano, A Smith, G Graham, ...
Science signaling 7 (324), ra42-ra42, 2014
3852014
Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway
EM Beauchamp, L Ringer, G Bulut, KP Sajwan, MD Hall, YC Lee, ...
The Journal of clinical investigation 121 (1), 148-160, 2011
3842011
The genomic landscape of juvenile myelomonocytic leukemia
E Stieglitz, AN Taylor-Weiner, TY Chang, LC Gelston, YD Wang, T Mazor, ...
Nature genetics 47 (11), 1326-1333, 2015
2742015
The insulin-like growth factor-I receptor is required for EWS/FLI-1 transformation of fibroblasts
JA Toretsky, T Kalebic, V Blakesley, D LeRoith, LJ Helman
Journal of Biological Chemistry 272 (49), 30822-30827, 1997
2741997
EWS–FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma
A Gorthi, JC Romero, E Loranc, L Cao, LA Lawrence, E Goodale, ...
Nature 555 (7696), 387-391, 2018
2692018
Geldanamycin selectively destabilizes and conformationally alters mutated p53.
MV Blagosklonny, J Toretsky, L Neckers
Oncogene 11 (5), 933-939, 1995
2491995
Assemblages: functional units formed by cellular phase separation
JA Toretsky, PE Wright
Journal of Cell Biology 206 (5), 579-588, 2014
2412014
Activation of the canonical Wnt pathway during genital keratinocyte transformation: a model for cervical cancer progression
A Üren, S Fallen, H Yuan, A Usubütün, T Küçükali, R Schlegel, ...
Cancer research 65 (14), 6199-6206, 2005
2112005
Biology of childhood osteogenic sarcoma and potential targets for therapeutic development: meeting summary
R Gorlick, P Anderson, I Andrulis, C Arndt, GP Beardsley, M Bernstein, ...
Clinical Cancer Research 9 (15), 5442-5453, 2003
2062003
Involvement of IGF-II in human cancer
JA Toretsky, LJ Helman
Journal of Endocrinology 149 (3), 367-372, 1996
2001996
GLI1 is a direct transcriptional target of EWS-FLI1 oncoprotein
E Beauchamp, G Bulut, O Abaan, K Chen, A Merchant, W Matsui, Y Endo, ...
Journal of Biological Chemistry 284 (14), 9074-9082, 2009
1842009
High ALDH activity identifies chemotherapy-resistant Ewing's sarcoma stem cells that retain sensitivity to EWS-FLI1 inhibition
O Awad, JT Yustein, P Shah, N Gul, V Katuri, A O'Neill, Y Kong, ML Brown, ...
PloS one 5 (11), e13943, 2010
1822010
Small molecule inhibitors of ezrin inhibit the invasive phenotype of osteosarcoma cells
G Bulut, SH Hong, K Chen, EM Beauchamp, S Rahim, GW Kosturko, ...
Oncogene 31 (3), 269-281, 2012
1812012
Oncogenic partnerships: EWS-FLI1 protein interactions initiate key pathways of Ewing's sarcoma
HV Erkizan, VN Uversky, JA Toretsky
Clinical Cancer Research 16 (16), 4077-4083, 2010
1612010
Oncoprotein EWS-FLI1 activity is enhanced by RNA helicase A
JA Toretsky, V Erkizan, A Levenson, OD Abaan, JD Parvin, TP Cripe, ...
Cancer research 66 (11), 5574-5581, 2006
1602006
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