| High contagiousness and rapid spread of severe acute respiratory syndrome coronavirus 2 S Sanche, YT Lin, C Xu, E Romero-Severson, N Hengartner, R Ke Emerging infectious diseases 26 (7), 1470, 2020 | 1868 | 2020 |
| The novel coronavirus, 2019-nCoV, is highly contagious and more infectious than initially estimated S Sanche, YT Lin, C Xu, E Romero-Severson, NW Hengartner, R Ke arXiv preprint arXiv:2002.03268, 2020 | 216 | 2020 |
| Timing of antiviral treatment initiation is critical to reduce SARS‐CoV‐2 viral load A Gonçalves, J Bertrand, R Ke, E Comets, X De Lamballerie, D Malvy, ... CPT: pharmacometrics & systems pharmacology 9 (9), 509-514, 2020 | 215 | 2020 |
| Transcriptional reprogramming during effector-to-memory transition renders CD4+ T cells permissive for latent HIV-1 infection L Shan, K Deng, H Gao, S Xing, AA Capoferri, CM Durand, SA Rabi, ... Immunity 47 (4), 766-775. e3, 2017 | 193 | 2017 |
| Longitudinal assessment of diagnostic test performance over the course of acute SARS-CoV-2 infection RL Smith, LL Gibson, PP Martinez, R Ke, A Mirza, M Conte, N Gallagher, ... The Journal of infectious diseases 224 (6), 976-982, 2021 | 142 | 2021 |
| Estimating the reproductive number R0 of SARS-CoV-2 in the United States and eight European countries and implications for vaccination R Ke, E Romero-Severson, S Sanche, N Hengartner Journal of theoretical biology 517, 110621, 2021 | 137 | 2021 |
| In vivo kinetics of SARS-CoV-2 infection and its relationship with a person’s infectiousness R Ke, C Zitzmann, DD Ho, RM Ribeiro, AS Perelson Proceedings of the National Academy of Sciences 118 (49), e2111477118, 2021 | 125 | 2021 |
| Daily longitudinal sampling of SARS-CoV-2 infection reveals substantial heterogeneity in infectiousness R Ke, PP Martinez, RL Smith, LL Gibson, A Mirza, M Conte, N Gallagher, ... Nature microbiology 7 (5), 640-652, 2022 | 109 | 2022 |
| A quantitative model used to compare within-host SARS-CoV-2, MERS-CoV, and SARS-CoV dynamics provides insights into the pathogenesis and treatment of SARS-CoV-2 KS Kim, K Ejima, S Iwanami, Y Fujita, H Ohashi, Y Koizumi, Y Asai, ... PLoS biology 19 (3), e3001128, 2021 | 106 | 2021 |
| Efficacy and safety of 3-week response-guided triple direct-acting antiviral therapy for chronic hepatitis C infection: a phase 2, open-label, proof-of-concept study G Lau, Y Benhamou, G Chen, J Li, Q Shao, D Ji, F Li, B Li, J Liu, J Hou, ... The lancet Gastroenterology & hepatology 1 (2), 97-104, 2016 | 105 | 2016 |
| Mechanistic modeling of SARS‐CoV‐2 and other infectious diseases and the effects of therapeutics AS Perelson, R Ke Clinical Pharmacology & Therapeutics 109 (4), 829-840, 2021 | 87 | 2021 |
| A quantitative high-resolution genetic profile rapidly identifies sequence determinants of hepatitis C viral fitness and drug sensitivity H Qi, CA Olson, NC Wu, R Ke, C Loverdo, V Chu, S Truong, R Remenyi, ... PLoS pathogens 10 (4), e1004064, 2014 | 81 | 2014 |
| Longitudinal analysis of SARS-CoV-2 vaccine breakthrough infections reveals limited infectious virus shedding and restricted tissue distribution R Ke, PP Martinez, RL Smith, LL Gibson, CJ Achenbach, S McFall, C Qi, ... Open Forum Infectious Diseases 9 (7), ofac192, 2022 | 77 | 2022 |
| Causes and consequences of spatial within-host viral spread ME Gallagher, CB Brooke, R Ke, K Koelle Viruses 10 (11), 627, 2018 | 65 | 2018 |
| Modeling the Effects of Vorinostat In Vivo Reveals both Transient and Delayed HIV Transcriptional Activation and Minimal Killing of Latently Infected Cells R Ke, SR Lewin, JH Elliott, AS Perelson PLoS pathogens 11 (10), e1005237, 2015 | 59 | 2015 |
| Phylodynamic analysis of the emergence and epidemiological impact of transmissible defective dengue viruses R Ke, J Aaskov, EC Holmes, JO Lloyd-Smith PLoS pathogens 9 (2), e1003193, 2013 | 58 | 2013 |
| Single cell heterogeneity in influenza A virus gene expression shapes the innate antiviral response to infection J Sun, JC Vera, J Drnevich, YT Lin, R Ke, CB Brooke PLoS pathogens 16 (7), e1008671, 2020 | 52 | 2020 |
| Kinetics of SARS-CoV-2 infection in the human upper and lower respiratory tracts and their relationship with infectiousness R Ke, C Zitzmann, RM Ribeiro, AS Perelson MedRxiv, 2020.09. 25.20201772, 2020 | 51 | 2020 |
| Excess deaths reveal the true spatial, temporal and demographic impact of COVID-19 on mortality in Ecuador L Cuéllar, I Torres, E Romero-Severson, R Mahesh, N Ortega, ... International journal of epidemiology 51 (1), 54-62, 2022 | 50 | 2022 |
| Fast spread of COVID-19 in Europe and the US suggests the necessity of early, strong and comprehensive interventions R Ke, S Sanche, E Romero-Severson, N Hengartner MedRxiv, 2020 | 50 | 2020 |
Alan S PerelsonSenior Fellow, Los Alamos National LaboratoryVerified email at lanl.gov
