Dirk Snyders
Dirk Snyders
Professor of Biomedical Sciences
Geverifieerd e-mailadres voor uantwerpen.be
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Class III antiarrhythmic agents have a lot of potential but a long way to go. Reduced effectiveness and dangers of reverse use dependence.
LM Hondeghem, DJ Snyders
Circulation 81 (2), 686-690, 1990
A rapidly activating and slowly inactivating potassium channel cloned from human heart. Functional analysis after stable mammalian cell culture expression.
DJ Snyders, MM Tamkun, PB Bennett
The Journal of General Physiology 101 (4), 513-543, 1993
Structure and function of cardiac potassium channels
DJ Snyders
Cardiovascular research 42 (2), 377-390, 1999
High affinity open channel block by dofetilide of HERG expressed in a human cell line.
DJ Snyders, A Chaudhary
Molecular pharmacology 49 (6), 949-955, 1996
Stereoselective block of cardiac sodium channels by bupivacaine in guinea pig ventricular myocytes
C Valenzuela, DJ Snyders, PB Bennett, J Tamargo, LM Hondeghem
Circulation 92 (10), 3014-3024, 1995
Ibutilide, a Methanesulfonanilide Antiarrhythmic, Is a Potent Blocker of the Rapidly Activating Delayed Rectifier K+ Current (IKr) in AT-1 Cells: Concentration-, Time …
T Yang, DJ Snyders, DM Roden
Circulation 91 (6), 1799-1806, 1995
Heteromultimeric assembly of human potassium channels. Molecular basis of a transient outward current?
S Po, S Roberds, DJ Snyders, MM Tamkun, PB Bennett
Circulation research 72 (6), 1326-1336, 1993
Stereoselective block of a human cardiac potassium channel (Kv1. 5) by bupivacaine enantiomers
C Valenzuela, E Delpon, MM Tamkun, J Tamargo, DJ Snyders
Biophysical Journal 69 (2), 418-427, 1995
Drug block of I Kr: model systems and relevance to human arrhythmias
T Yang, D Snyders, DM Roden
Journal of cardiovascular pharmacology 38 (5), 737-744, 2001
Obligatory heterotetramerization of three previously uncharacterized Kv channel α-subunits identified in the human genome
N Ottschytsch, A Raes, D Van Hoorick, DJ Snyders
Proceedings of the National Academy of Sciences 99 (12), 7986-7991, 2002
Rapid Inactivation Determines the Rectification and [K+]o Dependence of the Rapid Component of the Delayed Rectifier K+ Current in Cardiac Cells
T Yang, DJ Snyders, DM Roden
Circulation Research 80 (6), 782-789, 1997
A K+ channel splice variant common in human heart lacks a C-terminal domain required for expression of rapidly activating delayed rectifier current
S Kupershmidt, DJ Snyders, A Raes, DM Roden
Journal of Biological Chemistry 273 (42), 27231-27235, 1998
Molecular Analysis of a Binding Site for Quinidine in a Human Cardiac Delayed Rectifier K+ Channel: Role of S6 in Antiarrhythmic Drug Binding
SW Yeola, TC Rich, VN Uebele, MM Tamkun, DJ Snyders
Circulation Research 78 (6), 1105-1114, 1996
Functional differences in Kv1. 5 currents expressed in mammalian cell lines are due to the presence of endogenous Kvβ2. 1 subunits
VN Uebele, SK England, A Chaudhary, MM Tamkun, DJ Snyders
Journal of Biological Chemistry 271 (5), 2406-2412, 1996
Determinants of antiarrhythmic drug action: electrostatic and hydrophobic components of block of the human cardiac hKv1. 5 channel
DJ Snyders, SW Yeola
Circulation Research 77 (3), 575-583, 1995
Quinidine delays IK activation in guinea pig ventricular myocytes.
DM Roden, PB Bennett, DJ Snyders, JR Balser, LM Hondeghem
Circulation Research 62 (5), 1055-1058, 1988
The contribution of genes involved in potassium‐recycling in the inner ear to noise‐induced hearing loss
L Van Laer, PI Carlsson, N Ottschytsch, ML Bondeson, A Konings, ...
Human mutation 27 (8), 786-795, 2006
Electrophysiological and pharmacological correspondence between Kv4. 2 current and rat cardiac transient outward current
SW Yeola, DJ Snyders
Cardiovascular research 33 (3), 540-547, 1997
Molecular determinants of stereoselective bupivacaine block of hKv1. 5 channels
L Franqueza, M Longobardo, J Vicente, E Delpón, MM Tamkun, ...
Circulation research 81 (6), 1053-1064, 1997
Class III antiarrhythmic effects of zatebradine: time-, state-, use-, and voltage-dependent block of hKv1. 5 channels
C Valenzuela, E DelpoŽ n, L Franqueza, P Gay, J Tamargo, DJ Snyders
Circulation 94 (3), 562-570, 1996
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