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Bart De Strooper
Bart De Strooper
gewoon hoogleraar KU Leuven en onderzoeksdirecteur VIB
Geverifieerd e-mailadres voor cme.vib-kuleuven.be
Titel
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A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain
B De Strooper, W Annaert, P Cupers, P Saftig, K Craessaerts, JS Mumm, ...
Nature 398 (6727), 518-522, 1999
25601999
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
B De Strooper, P Saftig, K Craessaerts, H Vanderstichele, G Guhde, ...
Nature 391 (6665), 387-390, 1998
22771998
The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics
E Karran, M Mercken, BD Strooper
Nature reviews Drug discovery 10 (9), 698-712, 2011
22242011
The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes
I Benilova, E Karran, B De Strooper
Nature neuroscience 15 (3), 349-357, 2012
19172012
OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion
C Frezza, S Cipolat, OM De Brito, M Micaroni, GV Beznoussenko, ...
Cell 126 (1), 177-189, 2006
15332006
Cholesterol depletion inhibits the generation of β-amyloid in hippocampal neurons
M Simons, P Keller, B De Strooper, K Beyreuther, CG Dotti, K Simons
Proceedings of the National Academy of Sciences 95 (11), 6460-6464, 1998
14651998
Aph-1, Pen-2, and nicastrin with presenilin generate an active γ-secretase complex
B De Strooper
Neuron 38 (1), 9-12, 2003
12562003
Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/β-secretase expression
SS Hébert, K Horré, L Nicolaï, AS Papadopoulou, W Mandemakers, ...
Proceedings of the National Academy of Sciences 105 (17), 6415-6420, 2008
12302008
The cellular phase of Alzheimer’s disease
B De Strooper, E Karran
Cell 164 (4), 603-615, 2016
11572016
Control of peripheral nerve myelination by the ß-secretase BACE1
M Willem, AN Garratt, B Novak, M Citron, S Kaufmann, A Rittger, ...
Science 314 (5799), 664-666, 2006
8602006
Proteolytic processing and cell biological functions of the amyloid precursor protein
B De Strooper, W Annaert
Journal of cell science 113 (11), 1857-1870, 2000
8512000
The secretases: enzymes with therapeutic potential in Alzheimer disease
B De Strooper, R Vassar, T Golde
Nature reviews neurology 6 (2), 99-107, 2010
8162010
The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for α-secretase activity in fibroblasts
D Hartmann, B De Strooper, L Serneels, K Craessaerts, A Herreman, ...
Human molecular genetics 11 (21), 2615-2624, 2002
8062002
Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling
S Cipolat, T Rudka, D Hartmann, V Costa, L Serneels, K Craessaerts, ...
Cell 126 (1), 163-175, 2006
7752006
ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and β-catenin translocation
T Maretzky, K Reiss, A Ludwig, J Buchholz, F Scholz, E Proksch, ...
Proceedings of the National Academy of Sciences 102 (26), 9182-9187, 2005
7432005
Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations
H Tu, O Nelson, A Bezprozvanny, Z Wang, SF Lee, YH Hao, L Serneels, ...
Cell 126 (5), 981-993, 2006
7122006
Destabilization of β-catenin by mutations in presenilin-1 potentiates neuronal apoptosis
Z Zhang, H Hartmann, V Minh Do, D Abramowski, C Sturchler-Pierrat, ...
Nature 395 (6703), 698-702, 1998
6901998
Total inactivation of γ–secretase activity in presenilin-deficient embryonic stem cells
A Herreman, L Serneels, W Annaert, D Collen, L Schoonjans, ...
Nature cell biology 2 (7), 461-462, 2000
6282000
Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 …
A Herreman, D Hartmann, W Annaert, P Saftig, K Craessaerts, L Serneels, ...
Proceedings of the National Academy of Sciences 96 (21), 11872-11877, 1999
5831999
ADAM10 cleavage of N‐cadherin and regulation of cell–cell adhesion and β‐catenin nuclear signalling
K Reiss, T Maretzky, A Ludwig, T Tousseyn, B De Strooper, D Hartmann, ...
The EMBO journal 24 (4), 742-752, 2005
5732005
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