Mark S. Hipp
Mark S. Hipp
Groupleader, University Medical Center Groningen
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Molecular chaperone functions in protein folding and proteostasis
YE Kim, MS Hipp, A Bracher, M Hayer-Hartl, F Ulrich Hartl
Annual review of biochemistry 82, 323-355, 2013
Proteostasis impairment in protein-misfolding and-aggregation diseases
MS Hipp, SH Park, FU Hartl
Trends in cell biology 24 (9), 506-514, 2014
The proteostasis network and its decline in ageing
MS Hipp, P Kasturi, FU Hartl
Nature reviews Molecular cell biology 20 (7), 421-435, 2019
PolyQ proteins interfere with nuclear degradation of cytosolic proteins by sequestering the Sis1p chaperone
SH Park, Y Kukushkin, R Gupta, T Chen, A Konagai, MS Hipp, ...
Cell 154 (1), 134-145, 2013
Cytoplasmic protein aggregates interfere with nucleocytoplasmic transport of protein and RNA
AC Woerner, F Frottin, D Hornburg, LR Feng, F Meissner, M Patra, ...
Science 351 (6269), 173-176, 2016
In situ structure of neuronal C9orf72 poly-GA aggregates reveals proteasome recruitment
Q Guo, C Lehmer, A Martínez-Sánchez, T Rudack, F Beck, H Hartmann, ...
Cell 172 (4), 696-705. e12, 2018
FAT10, a ubiquitin-independent signal for proteasomal degradation
MS Hipp, B Kalveram, S Raasi, M Groettrup, G Schmidtke
Molecular and cellular biology 25 (9), 3483-3491, 2005
In situ architecture and cellular interactions of PolyQ inclusions
FJB Bäuerlein, I Saha, A Mishra, M Kalemanov, A Martínez-Sánchez, ...
Cell 171 (1), 179-187. e10, 2017
The nucleolus functions as a phase-separated protein quality control compartment
F Frottin, F Schueder, S Tiwary, R Gupta, R Körner, T Schlichthaerle, ...
Science 365 (6451), 342-347, 2019
Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate …
BE Riley, SE Kaiser, TA Shaler, ACY Ng, T Hara, MS Hipp, K Lage, ...
Journal of Cell Biology 191 (3), 537-552, 2010
Indirect inhibition of 26S proteasome activity in a cellular model of Huntington’s disease
MS Hipp, CN Patel, K Bersuker, BE Riley, SE Kaiser, TA Shaler, ...
Journal of Cell Biology 196 (5), 573-587, 2012
NEDD8 ultimate buster-1L interacts with the ubiquitin-like protein FAT10 and accelerates its degradation
MS Hipp, S Raasi, M Groettrup, G Schmidtke
Journal of Biological Chemistry 279 (16), 16503-16510, 2004
Proteasome inhibition leads to NF‐κB‐independent IL‐8 transactivation in human endothelial cells through induction of AP‐1
MS Hipp, C Urbich, P Mayer, J Wischhusen, M Weller, M Kracht, ...
European journal of immunology 32 (8), 2208-2217, 2002
The UBA domains of NUB1L are required for binding but not for accelerated degradation of the ubiquitin-like modifier FAT10
G Schmidtke, B Kalveram, E Weber, P Bochtler, S Lukasiak, MS Hipp, ...
Journal of Biological Chemistry 281 (29), 20045-20054, 2006
Proteotoxic stress and ageing triggers the loss of redox homeostasis across cellular compartments
J Kirstein, D Morito, T Kakihana, M Sugihara, A Minnen, MS Hipp, ...
The EMBO journal 34 (18), 2334-2349, 2015
Spatiotemporal proteomic profiling of Huntington’s disease inclusions reveals widespread loss of protein function
F Hosp, S Gutiérrez-Ángel, MH Schaefer, J Cox, F Meissner, MS Hipp, ...
Cell reports 21 (8), 2291-2303, 2017
Heat shock response activation exacerbates inclusion body formation in a cellular model of Huntington disease
K Bersuker, MS Hipp, B Calamini, RI Morimoto, RR Kopito
Journal of Biological Chemistry 288 (33), 23633-23638, 2013
Functional modules of the proteostasis network
GG Jayaraj, MS Hipp, FU Hartl
Cold Spring Harbor perspectives in biology 12 (1), a033951, 2020
Overexpression of Q-rich prion-like proteins suppresses polyQ cytotoxicity and alters the polyQ interactome
L Ripaud, V Chumakova, M Antonin, AR Hastie, S Pinkert, R Körner, ...
Proceedings of the National Academy of Sciences 111 (51), 18219-18224, 2014
The formation, function and regulation of amyloids: insights from structural biology
M Landreh, MR Sawaya, MS Hipp, DS Eisenberg, K Wüthrich, FU Hartl
Journal of internal medicine 280 (2), 164-176, 2016
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