Julian Downward
Julian Downward
Verified email at crick.ac.uk - Homepage
Cited by
Cited by
Intratumor heterogeneity and branched evolution revealed by multiregion sequencing
M Gerlinger, AJ Rowan, S Horswell, J Larkin, D Endesfelder, E Gronroos, ...
N Engl j Med 366, 883-892, 2012
Targeting RAS signalling pathways in cancer therapy
J Downward
Nature reviews cancer 3 (1), 11-22, 2003
Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells
A Ullrich, L Coussens, JS Hayflick, TJ Dull, A Gray, AW Tam, J Lee, ...
Nature 309 (5967), 418-425, 1984
Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences
J Downward, Y Yarden, E Mayes, G Scrace, N Totty, P Stockwell, A Ullrich, ...
Nature 307 (5951), 521-527, 1984
Phosphatidylinositol-3-OH kinase as a direct target of Ras
P Rodriguez-Viciana, PH Warne, R Dhand, B Vanhaesebroeck, I Gout, ...
Nature 370 (6490), 527-532, 1994
Mechanisms and consequences of activation of protein kinase B/Akt
J Downward
Current opinion in cell biology 10 (2), 262-267, 1998
Suppression of c-Myc-induced apoptosis by Ras signalling through PI (3) K and PKB
A Kauffmann-Zeh, P Rodriguez-Viciana, E Ulrich, C Gilbert, P Coffer, ...
Nature 385 (6616), 544-548, 1997
Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor
L Buday, J Downward
Cell 73 (3), 611-620, 1993
Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras
P Rodriguez-Viciana, PH Warne, A Khwaja, BM Marte, D Pappin, P Das, ...
Cell 89 (3), 457-467, 1997
Matrix adhesion and Ras transformation both activate a phosphoinositide 3‐OH kinase and protein kinase B/Akt cellular survival pathway
A Khwaja, P Rodriguez‐Viciana, S Wennström, PH Warne, J Downward
The EMBO journal 16 (10), 2783-2793, 1997
Stimulation of p21 ras upon T-cell activation
J Downward, JD Graves, PH Warne, S Rayter, DA Cantrell
Nature 346 (6286), 719-723, 1990
PI 3-kinase, Akt and cell survival
J Downward
Seminars in cell & developmental biology 15 (2), 177-182, 2004
Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro
PH Warne, PR Vician, J Downward
Nature 364 (6435), 352-355, 1993
Autophosphorylation sites on the epidermal growth factor receptor
J Downward, P Parker, MD Waterfield
Nature 311 (5985), 483-485, 1984
PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond
BM Marte, J Downward
Trends in biochemical sciences 22 (9), 355-358, 1997
Ras and TGFβ cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways
E Janda, K Lehmann, I Killisch, M Jechlinger, M Herzig, J Downward, ...
The Journal of cell biology 156 (2), 299-314, 2002
Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis
S Basu, NF Totty, MS Irwin, M Sudol, J Downward
Molecular cell 11 (1), 11-23, 2003
Expression cloning and characterization of the TGF-β type III receptor
XF Wang, HY Lin, E Ng-Eaton, J Downward, HF Lodish, RA Weinberg
Cell 67 (4), 797-805, 1991
Navigating gene expression using microarrays? a technology review.
A Schulze, J Downward
Nature cell biology 3 (8), 2001
Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients
TN Basu, DH Gutmann, JA Fletcher, TW Glover, FS Collins, J Downward
Nature 356 (6371), 713-715, 1992
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