| EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity J Bieschke, J Russ, RP Friedrich, DE Ehrnhoefer, H Wobst, ... Proceedings of the National Academy of Sciences 107 (17), 7710-7715, 2010 | 1076 | 2010 |
| The green tea polyphenol (−)‐epigallocatechin gallate prevents the aggregation of tau protein into toxic oligomers at substoichiometric ratios HJ Wobst, A Sharma, MI Diamond, EE Wanker, J Bieschke FEBS letters 589 (1), 77-83, 2015 | 220 | 2015 |
| A Decade of FDA-Approved Drugs (2010–2019): Trends and Future Directions DG Brown, HJ Wobst Journal of Medicinal Chemistry 64 (5), 2312-2338, 2021 | 192 | 2021 |
| Clinical development times for innovative drugs. DG Brown, HJ Wobst, A Kapoor, LA Kenna, N Southall Nature reviews. Drug discovery, 2021 | 89 | 2021 |
| The clinical trial landscape in amyotrophic lateral sclerosis—Past, present, and future HJ Wobst, KL Mack, DG Brown, NJ Brandon, J Shorter Medicinal Research Reviews, 2020 | 72 | 2020 |
| The small molecule CLP257 does not modify activity of the K+–Cl− co-transporter KCC2 but does potentiate GABAA receptor activity RA Cardarelli, K Jones, LI Pisella, HJ Wobst, LJ McWilliams, PM Sharpe, ... Nature medicine 23 (12), 1394-1396, 2017 | 50 | 2017 |
| Opportunities and Challenges in Phenotypic Screening for Neurodegenerative Disease Research DG Brown, HJ Wobst Journal of medicinal chemistry, 2019 | 47 | 2019 |
| Developmental regulation of KCC2 phosphorylation has long-term impacts on cognitive function YE Moore, LC Conway, HJ Wobst, NJ Brandon, TZ Deeb, SJ Moss Frontiers in molecular neuroscience 12, 173, 2019 | 43 | 2019 |
| Emerging Small Molecule Therapeutic Approaches to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia DG Brown, J Shorter, HJ Wobst Bioorganic & Medicinal Chemistry Letters, 126942, 2019 | 34 | 2019 |
| Cytoplasmic relocalization of TAR DNA-binding protein 43 is not sufficient to reproduce cellular pathologies associated with ALS in vitro HJ Wobst, SS Wesolowski, J Chadchankar, L Delsing, S Jacobsen, ... Frontiers in molecular neuroscience 10, 46, 2017 | 31 | 2017 |
| Truncation of the TAR DNA-binding protein 43 is not a prerequisite for cytoplasmic relocalization, and is suppressed by caspase inhibition and by introduction of the A90V … HJ Wobst, L Delsing, NJ Brandon, SJ Moss PloS one 12 (5), 2017 | 28 | 2017 |
| Wild-type, but not mutant N296H, human tau restores Ab-mediated inhibition of LTP in Tau-/-mice M Vargas-Caballero, F Denk, HJ Wobst, E Arch, CM Pegasiou, PL Oliver, ... Frontiers in Neuroscience 11, 201, 2017 | 20 | 2017 |
| Identification of a Core Amino Acid Motif within the α Subunit of GABAARs that Promotes Inhibitory Synaptogenesis and Resilience to Seizures AJ Nathanson, Y Zhang, JL Smalley, TA Ollerhead, MAR Santos, ... Cell reports 28 (3), 670-681. e8, 2019 | 19 | 2019 |
| Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells J Chadchankar, V Korboukh, LC Conway, HJ Wobst, CA Walker, P Doig, ... PloS one 14 (11), 2019 | 18 | 2019 |
| Increased 4R tau expression and behavioural changes in a novel MAPT-N296H genomic mouse model of tauopathy HJ Wobst, F Denk, PL Oliver, A Livieratos, TN Taylor, MH Knudsen, ... Scientific reports 7 (1), 1-14, 2017 | 15 | 2017 |
| Promiscuity of in vitro secondary pharmacology assays and implications for lead optimization strategies DG Brown, GF Smith, HJ Wobst Journal of medicinal chemistry, 2019 | 14 | 2019 |
| Opposing roles of p38α-mediated phosphorylation and arginine methylation in driving TDP-43 proteinopathy M Aikio, HJ Wobst, HM Odeh, BL Lee, B Class, TA Ollerhead, KL Mack, ... bioRxiv, 2021.08. 04.455154, 2021 | 6 | 2021 |
| Analysis of orphan designation status for FDA approved drugs, and case studies in oncology, neuroscience and metabolic diseases DG Brown, HJ Wobst Bioorganic & Medicinal Chemistry, 117170, 2023 | 1 | 2023 |
| A survey of the clinical pipeline in neuroscience DG Brown, HJ Wobst Bioorganic & Medicinal Chemistry Letters 56, 128482, 2022 | | 2022 |
| Mouse models for the investigation of MAPT and its role in neurodegenerative disease HJ Wobst University of Oxford, 2013 | | 2013 |
