| Targeting the epigenetic regulation of antitumour immunity SJ Hogg, PA Beavis, MA Dawson, RW Johnstone Nature reviews Drug discovery 19 (11), 776-800, 2020 | 300 | 2020 |
| Tumor immune evasion arises through loss of TNF sensitivity CJ Kearney, SJ Vervoort, SJ Hogg, KM Ramsbottom, AJ Freeman, ... Science immunology 3 (23), eaar3451, 2018 | 286 | 2018 |
| BET-bromodomain inhibitors engage the host immune system and regulate expression of the immune checkpoint ligand PD-L1 SJ Hogg, SJ Vervoort, S Deswal, CJ Ott, J Li, LA Cluse, PA Beavis, ... Cell reports 18 (9), 2162-2174, 2017 | 271 | 2017 |
| Pharmacologic modulation of RNA splicing enhances anti-tumor immunity SX Lu, E De Neef, JD Thomas, E Sabio, B Rousseau, M Gigoux, DA Knorr, ... Cell 184 (15), 4032-4047. e31, 2021 | 151 | 2021 |
| CDK9 inhibition by dinaciclib potently suppresses Mcl-1 to induce durable apoptotic responses in aggressive MYC-driven B-cell lymphoma in vivo GP Gregory, SJ Hogg, LM Kats, E Vidacs, AJ Baker, O Gilan, M Lefebure, ... Leukemia 29 (6), 1437-1441, 2015 | 147 | 2015 |
| Altered RNA splicing by mutant p53 activates oncogenic RAS signaling in pancreatic cancer LF Escobar-Hoyos, A Penson, R Kannan, H Cho, CH Pan, RK Singh, ... Cancer cell 38 (2), 198-211. e8, 2020 | 129 | 2020 |
| Mechanisms of resistance to noncovalent Bruton’s tyrosine kinase inhibitors E Wang, X Mi, MC Thompson, S Montoya, RQ Notti, J Afaghani, ... New England Journal of Medicine 386 (8), 735-743, 2022 | 117 | 2022 |
| The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer SJ Vervoort, SA Welsh, JR Devlin, E Barbieri, DA Knight, S Offley, ... Cell 184 (12), 3143-3162. e32, 2021 | 114 | 2021 |
| CDK13 cooperates with CDK12 to control global RNA polymerase II processivity Z Fan, JR Devlin, SJ Hogg, MA Doyle, PF Harrison, I Todorovski, ... Science advances 6 (18), eaaz5041, 2020 | 100 | 2020 |
| Minor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition D Inoue, JT Polaski, J Taylor, P Castel, S Chen, S Kobayashi, SJ Hogg, ... Nature genetics 53 (5), 707-718, 2021 | 75 | 2021 |
| Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition SJ Hogg, O Motorna, LA Cluse, TM Johanson, HD Coughlan, R Raviram, ... Molecular cell 81 (10), 2183-2200. e13, 2021 | 72 | 2021 |
| BET inhibition induces apoptosis in aggressive B-cell lymphoma via epigenetic regulation of BCL-2 family members SJ Hogg, A Newbold, SJ Vervoort, LA Cluse, BP Martin, GP Gregory, ... Molecular cancer therapeutics 15 (9), 2030-2041, 2016 | 72 | 2016 |
| The natural function of the malaria parasite’s chloroquine resistance transporter SH Shafik, SA Cobbold, K Barkat, SN Richards, NS Lancaster, M Llinás, ... Nature communications 11 (1), 3922, 2020 | 68 | 2020 |
| Serine biosynthesis is a metabolic vulnerability in flt3-itd–driven acute myeloid leukemia S Bjelosevic, E Gruber, A Newbold, C Shembrey, JR Devlin, SJ Hogg, ... Cancer discovery 11 (6), 1582-1599, 2021 | 40 | 2021 |
| The drug vehicle and solvent N-methylpyrrolidone is an immunomodulator and antimyeloma compound J Shortt, AK Hsu, BP Martin, K Doggett, GM Matthews, MA Doyle, J Ellul, ... Cell reports 7 (4), 1009-1019, 2014 | 40 | 2014 |
| The SMAC mimetic, LCL-161, reduces survival in aggressive MYC-driven lymphoma while promoting susceptibility to endotoxic shock AC West, BP Martin, DA Andrews, SJ Hogg, A Banerjee, G Grigoriadis, ... Oncogenesis 5 (4), e216-e216, 2016 | 39 | 2016 |
| Resveratrol, acetyl-resveratrol, and polydatin exhibit antigrowth activity against 3D cell aggregates of the SKOV-3 and OVCAR-8 ovarian cancer cell lines SJ Hogg, K Chitcholtan, W Hassan, PH Sykes, A Garrill Obstetrics and gynecology international 2015, 2015 | 39 | 2015 |
| Proteomic discovery of chemical probes that perturb protein complexes in human cells MR Lazear, JR Remsberg, MG Jaeger, K Rothamel, H Her, KE DeMeester, ... Molecular Cell 83 (10), 1725-1742. e12, 2023 | 34 | 2023 |
| Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction KM Fujihara, BZ Zhang, TD Jackson, MO Ogunkola, B Nijagal, JV Milne, ... Science Advances 8 (37), eabm9427, 2022 | 30 | 2022 |
| Modulation of RNA splicing enhances response to BCL2 inhibition in leukemia E Wang, JMB Pineda, WJ Kim, S Chen, J Bourcier, M Stahl, SJ Hogg, ... Cancer Cell 41 (1), 164-180. e8, 2023 | 24 | 2023 |
Ricky JohnstoneProfessor of Cancer Research, Peter MacCAllum Cancer CentreGeverifieerd e-mailadres voor petermac.org
