Virtual screening and its integration with modern drug design technologies AD Andricopulo, RVC Guido, G Oliva Current medicinal chemistry 15 (1), 37-46, 2008 | 283 | 2008 |
Planejamento de fármacos, biotecnologia e química medicinal: aplicações em doenças infecciosas RVC Guido, AD Andricopulo, G Oliva Estudos avançados 24, 81-98, 2010 | 143 | 2010 |
Advances in prodrug design AT de Albuquerque Silva, MC Chung, LF Castro, RV Carvalho Guido, ... Mini reviews in medicinal chemistry 5 (10), 893-914, 2005 | 135 | 2005 |
Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase AS Godoy, GMA Lima, KIZ Oliveira, NU Torres, FV Maluf, RVC Guido, ... Nature communications 8 (1), 14764, 2017 | 120 | 2017 |
Synthesis, biological evaluation, and molecular modeling of chalcone derivatives as potent inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatases (PtpA and PtpB) LD Chiaradia, PGA Martins, MNS Cordeiro, RVC Guido, G Ecco, ... Journal of medicinal chemistry 55 (1), 390-402, 2012 | 119 | 2012 |
Inhibition of Mycobacterium tuberculosis tyrosine phosphatase PtpA by synthetic chalcones: kinetics, molecular modeling, toxicity and effect on growth. A Mascarello, LD Chiaradia, J Vernal, A Villarino, RVC Guido, P Perizzolo, ... Bioorganic & Medicinal Chemistry 18 (4), 1101-1109, 2010 | 119 | 2010 |
Synthesis and in vitro evaluation of potential antichagasic hydroxymethylnitrofurazone (NFOH-121): a new nitrofurazone prodrug MC Chung, RVC Güido, TF Martinelli, MF Gonçalves, MC Polli, ... Bioorganic & medicinal chemistry 11 (22), 4779-4783, 2003 | 110 | 2003 |
Discovery of New Inhibitors of Mycobacterium tuberculosis InhA Enzyme Using Virtual Screening and a 3D-Pharmacophore-Based Approach I Pauli, RN Dos Santos, DC Rostirolla, LK Martinelli, RG Ducati, ... Journal of chemical information and modeling 53 (9), 2390-2401, 2013 | 94 | 2013 |
Quantitative structure–activity relationships for a series of inhibitors of cruzain from Trypanosoma cruzi: Molecular modeling, CoMFA and CoMSIA studies GHG Trossini, RVC Guido, G Oliva, EI Ferreira, AD Andricopulo Journal of Molecular Graphics and Modelling 28 (1), 3-11, 2009 | 72 | 2009 |
Discovery of new inhibitors of Schistosoma mansoni PNP by pharmacophore-based virtual screening MP Postigo, RVC Guido, G Oliva, MS Castilho, I da R. Pitta, ... Journal of chemical information and modeling 50 (9), 1693-1705, 2010 | 69 | 2010 |
Modern Drug Discovery Technologies: Opportunities and Challenges in Lead Discovery R VC Guido, G Oliva, A D Andricopulo Combinatorial Chemistry &# 38; High Throughput Screening 14 (10), 830-839, 2011 | 58 | 2011 |
Structural basis for selective inhibition of trypanosomatid glyceraldehyde-3-phosphate dehydrogenase: molecular docking and 3D QSAR studies RVC Guido, G Oliva, CA Montanari, AD Andricopulo Journal of chemical information and modeling 48 (4), 918-929, 2008 | 56 | 2008 |
A novel approach to inhibit bone resorption: exosite inhibitors against cathepsin K P Panwar, K Søe, RVC Guido, RVC Bueno, JM Delaisse, D Brömme British journal of pharmacology 173 (2), 396-410, 2016 | 55 | 2016 |
Isolation, Derivative Synthesis, and Structure–Activity Relationships of Antiparasitic Bromopyrrole Alkaloids from the Marine Sponge Tedania brasiliensis LLL Parra, AF Bertonha, IRM Severo, ACC Aguiar, GE de Souza, G Oliva, ... Journal of natural products 81 (1), 188-202, 2018 | 53 | 2018 |
Discovery of Marinoquinolines as Potent and Fast-Acting Plasmodium falciparum Inhibitors with in Vivo Activity ACC Aguiar, M Panciera, EF Simao dos Santos, MK Singh, ML Garcia, ... Journal of medicinal chemistry 61 (13), 5547-5568, 2018 | 50 | 2018 |
Structural requirements for the collagenase and elastase activity of cathepsin K and its selective inhibition by an exosite inhibitor V Sharma, P Panwar, AJ O’Donoghue, H Cui, RVC Guido, CS Craik, ... Biochemical Journal 465 (1), 163-173, 2015 | 50 | 2015 |
Sulfonyl-hydrazones of cyclic imides derivatives as potent inhibitors of the Mycobacterium tuberculosis protein tyrosine phosphatase B (PtpB) KN de Oliveira, LD Chiaradia, PGA Martins, A Mascarello, MNS Cordeiro, ... Med. Chem. Commun. 2 (6), 500-504, 2011 | 50 | 2011 |
2D Quantitative structure–activity relationship studies on a series of cholesteryl ester transfer protein inhibitors MS Castilho, RVC Guido, AD Andricopulo Bioorganic & medicinal chemistry 15 (18), 6242-6252, 2007 | 47 | 2007 |
Insecticidal activity of an essential oil of Tagetes patula L. (Asteraceae) on common bed bug Cimex lectularius L. and molecular docking of major compounds at the catalytic … FAS Politi, JD Nascimento, AA da Silva, IJ Moro, ML Garcia, RVC Guido, ... Parasitology research 116, 415-424, 2017 | 46 | 2017 |
Acridone alkaloids as potent inhibitors of cathepsin V RP Severino, RVC Guido, EF Marques, D Brömme, MFGF da Silva, ... Bioorganic & medicinal chemistry 19 (4), 1477-1481, 2011 | 44 | 2011 |