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Xinhong Chen
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Negative feedback control of neuronal activity by microglia
A Badimon, HJ Strasburger, P Ayata, X Chen, A Nair, A Ikegami, P Hwang, ...
Nature 586 (7829), 417-423, 2020
6202020
A cortical-brainstem circuit predicts and governs compulsive alcohol drinking
CA Siciliano, H Noamany, CJ Chang, AR Brown, X Chen, D Leible, ...
Science 366 (6468), 1008-1012, 2019
1462019
Multiplexed Cre-dependent selection yields systemic AAVs for targeting distinct brain cell types
S Ravindra Kumar, TF Miles, X Chen, D Brown, T Dobreva, Q Huang, ...
Nature methods 17 (5), 541-550, 2020
1422020
Engineered AAVs for non-invasive gene delivery to rodent and non-human primate nervous systems
X Chen, SR Kumar, CD Adams, D Yang, T Wang, DA Wolfe, CM Arokiaraj, ...
Neuron 110 (14), 2242-2257. e6, 2022
682022
Adeno-associated virus toolkit to target diverse brain cells
RC Challis, S Ravindra Kumar, X Chen, D Goertsen, GM Coughlin, ...
Annual review of neuroscience 45, 447-469, 2022
602022
Super-resolution label-free volumetric vibrational imaging
C Qian, K Miao, LE Lin, X Chen, J Du, L Wei
Nature Communications 12 (1), 3648, 2021
352021
Dorsal raphe dopamine neurons signal motivational salience dependent on internal state, expectation, and behavioral context
JR Cho, X Chen, A Kahan, JE Robinson, DA Wagenaar, V Gradinaru
Journal of Neuroscience 41 (12), 2645-2655, 2021
28*2021
Adeno-associated viral vectors for functional intravenous gene transfer throughout the non-human primate brain
MR Chuapoco, NC Flytzanis, N Goeden, J Christopher Octeau, KM Roxas, ...
Nature nanotechnology 18 (10), 1241-1251, 2023
242023
Spatial transcriptomics for profiling the tropism of viral vectors in tissues
MJ Jang, GM Coughlin, CR Jackson, X Chen, MR Chuapoco, ...
Nature biotechnology 41 (9), 1272-1286, 2023
222023
Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates
X Chen, DA Wolfe, DS Bindu, M Zhang, N Taskin, D Goertsen, TF Shay, ...
Nature communications 14 (1), 3345, 2023
142023
Primate-conserved carbonic anhydrase IV and murine-restricted LY6C1 enable blood-brain barrier crossing by engineered viral vectors
TF Shay, EE Sullivan, X Ding, X Chen, S Ravindra Kumar, D Goertsen, ...
Science advances 9 (16), eadg6618, 2023
14*2023
Advances in AAV technology for delivering genetically encoded cargo to the nonhuman primate nervous system
LJ Campos, CM Arokiaraj, MR Chuapoco, X Chen, N Goeden, ...
Current Research in Neurobiology, 100086, 2023
122023
Or47b plays a role in Drosophila males' preference for younger mates
L Zhuang, Y Sun, M Hu, C Wu, X La, X Chen, Y Feng, X Wang, Y Hu, ...
Open biology 6 (6), 160086, 2016
112016
Light-guided sectioning for precise in situ localization and tissue interface analysis for brain-implanted optical fibers and GRIN lenses
A Kahan, A Greenbaum, MJ Jang, JE Robinson, JR Cho, X Chen, ...
Cell reports 36 (13), 2021
102021
Myc inhibits JNK-mediated cell death in vivo
J Huang, Y Feng, X Chen, W Li, L Xue
Apoptosis 22, 479-490, 2017
82017
Victoria Omstead, Naz Taskin, Natalie Weed, Boaz P. Levi, Jonathan T. Ting, Cory T. Miller
MR Chuapoco, NC Flytzanis, N Goeden, JC Octeau, KM Roxas, KY Chan, ...
Benjamin E. Deverman, James Pickel, Lin Tian, Andrew S. Fox, Viviana Gradinaru, 2023
52023
Establishment of a Drosophila AD model
X Wang, Y Zhao, Y Hu, P Ren, Y Sun, X Guo, X Huang, Y Zhu, X Chen, ...
Journal of Biological Methods 3 (2), e43, 2016
32016
Intravenous functional gene transfer throughout the brain of non-human primates using AAV
MR Chuapoco, NC Flytzanis, N Goeden, JC Octeau, KM Roxas, KY Chan, ...
Research Square, 2023
22023
Human cell surface-AAV interactomes identify LRP6 as blood-brain-barrier transcytosis receptor and immune cytokine IL3 as AAV9 binder
TF Shay, S Jang, X Chen, B Walker, C Tebbutt, DA Wolfe, TJ Brittain, ...
bioRxiv, 2024.01. 05.574399, 2024
12024
Fast, accurate ranking of engineered proteins by target binding propensity using structure modeling
X Ding, X Chen, EE Sullivan, TF Shay, V Gradinaru
Molecular Therapy, 2024
2024
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Articles 1–20