The small molecule nobiletin targets the molecular oscillator to enhance circadian rhythms and protect against metabolic syndrome B He, K Nohara, N Park, YS Park, B Guillory, Z Zhao, JM Garcia, N Koike, ... Cell metabolism 23 (4), 610-621, 2016 | 437 | 2016 |
Nobiletin fortifies mitochondrial respiration in skeletal muscle to promote healthy aging against metabolic challenge K Nohara, V Mallampalli, T Nemkov, M Wirianto, J Yang, Y Ye, Y Sun, ... Nature communications 10 (1), 3923, 2019 | 146 | 2019 |
Early-life exposure to testosterone programs the hypothalamic melanocortin system K Nohara, Y Zhang, RS Waraich, A Laque, JP Tiano, J Tong, H Münzberg, ... Endocrinology 152 (4), 1661-1669, 2011 | 145 | 2011 |
Transmissible microbial and metabolomic remodeling by soluble dietary fiber improves metabolic homeostasis B He, K Nohara, NJ Ajami, RD Michalek, X Tian, M Wong, ... Scientific reports 5 (1), 10604, 2015 | 87 | 2015 |
Developmental androgen excess programs sympathetic tone and adipose tissue dysfunction and predisposes to a cardiometabolic syndrome in female mice K Nohara, RS Waraich, S Liu, M Ferron, A Waget, MS Meyers, G Karsenty, ... American Journal of Physiology-Endocrinology and Metabolism 304 (12), E1321 …, 2013 | 84 | 2013 |
Period2 3′-UTR and microRNA-24 regulate circadian rhythms by repressing PERIOD2 protein accumulation SH Yoo, S Kojima, K Shimomura, N Koike, ED Buhr, T Furukawa, CH Ko, ... Proceedings of the National Academy of Sciences 114 (42), E8855-E8864, 2017 | 81 | 2017 |
Central mechanisms of adiposity in adult female mice with androgen excess K Nohara, A Laque, C Allard, H Münzberg, F Mauvais‐Jarvis Obesity 22 (6), 1477-1484, 2014 | 71 | 2014 |
Myricetin improves endurance capacity and mitochondrial density by activating SIRT1 and PGC-1α HY Jung, D Lee, HG Ryu, BH Choi, Y Go, N Lee, D Lee, HG Son, J Jeon, ... Scientific reports 7 (1), 6237, 2017 | 60 | 2017 |
Ammonia-lowering activities and carbamoyl phosphate synthetase 1 (Cps1) induction mechanism of a natural flavonoid K Nohara, Y Shin, N Park, K Jeong, B He, N Koike, SH Yoo, Z Chen Nutrition & metabolism 12, 1-12, 2015 | 44 | 2015 |
Coordinate regulation of cholesterol and bile acid metabolism by the clock modifier nobiletin in metabolically challenged old mice K Nohara, T Nemkov, A D’Alessandro, SH Yoo, Z Chen International journal of molecular sciences 20 (17), 4281, 2019 | 43 | 2019 |
Manipulating the circadian and sleep cycles to protect against metabolic disease K Nohara, SH Yoo, Z Chen Frontiers in endocrinology 6, 35, 2015 | 43 | 2015 |
Dual attenuation of proteasomal and autophagic BMAL1 degradation in ClockΔ19/+ mice contributes to improved glucose homeostasis K Jeong, B He, K Nohara, N Park, Y Shin, S Kim, K Shimomura, N Koike, ... Scientific reports 5 (1), 12801, 2015 | 40 | 2015 |
T-2 toxin initially activates caspase-2 and induces apoptosis in U937 cells P Huang, K Akagawa, Y Yokoyama, K Nohara, K Kano, K Morimoto Toxicology letters 170 (1), 1-10, 2007 | 40 | 2007 |
Effects of the clock modulator nobiletin on circadian rhythms and pathophysiology in female mice of an Alzheimer’s disease model E Kim, K Nohara, M Wirianto, G Escobedo Jr, JY Lim, R Morales, SH Yoo, ... Biomolecules 11 (7), 1004, 2021 | 32 | 2021 |
Developmental androgen excess disrupts reproduction and energy homeostasis in adult male mice K Nohara, S Liu, MS Meyers, A Waget, M Ferron, G Karsenty, R Burcelin, ... J Endocrinol 219 (3), 259-268, 2013 | 31 | 2013 |
The clock modulator Nobiletin mitigates astrogliosis‐associated neuroinflammation and disease hallmarks in an Alzheimer’s disease model M Wirianto, CY Wang, E Kim, N Koike, R Gomez‐Gutierrez, K Nohara, ... The FASEB Journal 36 (3), 2022 | 26 | 2022 |
The important role of caspase-10 in sodium butyrate-induced apoptosis K Nohara, Y Yokoyama, K Kano Kobe J Med Sci 53 (5), 265-73, 2007 | 25 | 2007 |
Cardiolipin synthesis in skeletal muscle is rhythmic and modifiable by age and diet K Nohara, E Kim, M Wirianto, E Mileykovskaya, W Dowhan, Z Chen, ... Oxidative medicine and cellular longevity 2020, 2020 | 19 | 2020 |
Generation of reactive oxygen species is an early event in dolichyl phosphate‐induced apoptosis Y Yokoyama, K Nohara, T Okubo, I Kano, K Akagawa, K Kano Journal of cellular biochemistry 100 (2), 349-361, 2007 | 10 | 2007 |
The polymethoxyflavone sudachitin modulates the circadian clock and improves liver physiology K Mawatari, N Koike, K Nohara, M Wirianto, T Uebanso, T Shimohata, ... Molecular Nutrition & Food Research 67 (9), 2200270, 2023 | 7 | 2023 |