| Misfolded proteinase K–resistant hyperphosphorylated α-synuclein in aged transgenic mice with locomotor deterioration and in human α-synucleinopathies M Neumann, PJ Kahle, BI Giasson, L Ozmen, E Borroni, W Spooren, ... The Journal of clinical investigation 110 (10), 1429-1439, 2002 | 468 | 2002 |
| Trace amine-associated receptor 1 modulates dopaminergic activity L Lindemann, CA Meyer, K Jeanneau, A Bradaia, L Ozmen, ... Journal of Pharmacology and Experimental Therapeutics 324 (3), 948-956, 2008 | 343 | 2008 |
| Determination of the role of the 5-ht6 receptor in the rat brain: a study using antisense oligonucleotides. A Bourson, E Borroni, RH Austin, FJJ Monsma, AJ Sleight Journal of Pharmacology and Experimental Therapeutics 274 (1), 173-180, 1995 | 246 | 1995 |
| Influence of the 5-HT6 Receptor on Acetylcholine Release in the Cortex: Pharmacological Characterization of 4-(2-Bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine, a … C Riemer, E Borroni, B Levet-Trafit, JR Martin, S Poli, RHP Porter, M Bös Journal of medicinal chemistry 46 (7), 1273-1276, 2003 | 239 | 2003 |
| Effect of bitopertin, a glycine reuptake inhibitor, on negative symptoms of schizophrenia: a randomized, double-blind, proof-of-concept study D Umbricht, D Alberati, M Martin-Facklam, E Borroni, EA Youssef, ... JAMA psychiatry 71 (6), 637-646, 2014 | 232 | 2014 |
| Age-dependent cognitive decline and amygdala pathology in α-synuclein transgenic mice C Freichel, M Neumann, T Ballard, V Müller, M Woolley, L Ozmen, ... Neurobiology of aging 28 (9), 1421-1435, 2007 | 216 | 2007 |
| RO4938581, a novel cognitive enhancer acting at GABAA α5 subunit-containing receptors TM Ballard, F Knoflach, E Prinssen, E Borroni, JA Vivian, J Basile, ... Psychopharmacology 202, 207-223, 2009 | 210 | 2009 |
| Selective GlyT1 Inhibitors: Discovery of [4-(3-Fluoro-5-trifluoromethylpyridin-2-yl)piperazin-1-yl][5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methylethoxy)phenyl … E Pinard, A Alanine, D Alberati, M Bender, E Borroni, P Bourdeaux, ... Journal of medicinal chemistry 53 (12), 4603-4614, 2010 | 186 | 2010 |
| Accuracy of tau positron emission tomography as a prognostic marker in preclinical and prodromal Alzheimer disease: a head-to-head comparison against amyloid positron emission … R Ossenkoppele, R Smith, N Mattsson-Carlgren, C Groot, A Leuzy, ... JAMA neurology 78 (8), 961-971, 2021 | 174 | 2021 |
| Severe impairment of NMDA receptor function in mice carrying targeted point mutations in the glycine binding site results in drug-resistant nonhabituating hyperactivity TM Ballard, M Pauly-Evers, GA Higgins, AM Ouagazzal, V Mutel, ... Journal of Neuroscience 22 (15), 6713-6723, 2002 | 165 | 2002 |
| Diagnostic performance of RO948 F 18 tau positron emission tomography in the differentiation of Alzheimer disease from other neurodegenerative disorders A Leuzy, R Smith, R Ossenkoppele, A Santillo, E Borroni, G Klein, ... JAMA neurology 77 (8), 955-965, 2020 | 156 | 2020 |
| Orexin receptor 2 expression in the posterior hypothalamus rescues sleepiness in narcoleptic mice T Mochizuki, E Arrigoni, JN Marcus, EL Clark, M Yamamoto, M Honer, ... Proceedings of the National Academy of Sciences 108 (11), 4471-4476, 2011 | 146 | 2011 |
| Glycine reuptake inhibitor RG1678: a pharmacologic characterization of an investigational agent for the treatment of schizophrenia D Alberati, JL Moreau, J Lengyel, N Hauser, R Mory, E Borroni, E Pinard, ... Neuropharmacology 62 (2), 1152-1161, 2012 | 144 | 2012 |
| Impaired cannabinoid receptor type 1 signaling interferes with stress-coping behavior in mice MA Steiner, K Wanisch, K Monory, G Marsicano, E Borroni, H Bächli, ... The pharmacogenomics journal 8 (3), 196-208, 2008 | 144 | 2008 |
| Prepulse inhibition deficits of the startle reflex in neonatal ventral hippocampal–lesioned rats: reversal by glycine and a glycine transporter inhibitor G Le Pen, J Kew, D Alberati, E Borroni, MP Heitz, JL Moreau Biological Psychiatry 54 (11), 1162-1170, 2003 | 128 | 2003 |
| Increased basal ganglia binding of 18F‐AV‐1451 in patients with progressive supranuclear palsy R Smith, M Schain, C Nilsson, O Strandberg, T Olsson, D Hägerström, ... Movement Disorders 32 (1), 108-114, 2017 | 127 | 2017 |
| Dual hypocretin receptor antagonism is more effective for sleep promotion than antagonism of either receptor alone SR Morairty, FG Revel, P Malherbe, JL Moreau, D Valladao, JG Wettstein, ... PloS one 7 (7), e39131, 2012 | 123 | 2012 |
| Biochemical and behavioural characterization of EMPA, a novel high‐affinity, selective antagonist for the OX2 receptor P Malherbe, E Borroni, L Gobbi, H Knust, M Nettekoven, E Pinard, ... British journal of pharmacology 156 (8), 1326-1341, 2009 | 111 | 2009 |
| Adenosine receptor ligands and their use in the treatment of disease EM Borroni, G Huber-Trottmann, GJ Kilpatrick, RD Norcross US Patent 6,586,441, 2003 | 104 | 2003 |
| Pharmacology of basimglurant (RO4917523, RG7090), a unique metabotropic glutamate receptor 5 negative allosteric modulator in clinical development for depression L Lindemann, RH Porter, SH Scharf, B Kuennecke, A Bruns, ... Journal of Pharmacology and Experimental Therapeutics 353 (1), 213-233, 2015 | 94 | 2015 |
