| Functional siRNAs and miRNAs exhibit strand bias A Khvorova, A Reynolds, SD Jayasena Cell 115 (2), 209-216, 2003 | 3916 | 2003 |
| Rational siRNA design for RNA interference A Reynolds, D Leake, Q Boese, S Scaringe, WS Marshall, A Khvorova Nature biotechnology 22 (3), 326-330, 2004 | 2911 | 2004 |
| 3′ UTR seed matches, but not overall identity, are associated with RNAi off-targets A Birmingham, EM Anderson, A Reynolds, D Ilsley-Tyree, D Leake, ... Nature methods 3 (3), 199-204, 2006 | 1181 | 2006 |
| Position-specific chemical modification of siRNAs reduces “off-target” transcript silencing AL Jackson, J Burchard, D Leake, A Reynolds, J Schelter, J Guo, ... Rna 12 (7), 1197-1205, 2006 | 1048 | 2006 |
| Functional and hyperfunctional siRNA A Khvorova, A Reynolds, D Leake, W Marshall, S Scaringe US Patent 8,090,542, 2012 | 966 | 2012 |
| Off-target effects by siRNA can induce toxic phenotype Y Fedorov, EM Anderson, A Birmingham, A Reynolds, J Karpilow, ... Rna 12 (7), 1188-1196, 2006 | 656 | 2006 |
| Methods and compositions for selecting sirna of improved functionality A Khvorova, A Reynolds, D Leake, W Marshall, S Read, S Scaringe US Patent App. 10/940,892, 2012 | 557 | 2012 |
| Functional and hyperfunctional siRNA A Khvorova, A Reynolds, D Leake, W Marshall, S Scaringe, S Read US Patent 7,691,997, 2010 | 514 | 2010 |
| Identification of genes that regulate epithelial cell migration using an siRNA screening approach KJ Simpson, LM Selfors, J Bui, A Reynolds, D Leake, A Khvorova, ... Nature cell biology 10 (9), 1027-1038, 2008 | 491 | 2008 |
| Induction of the interferon response by siRNA is cell type–and duplex length–dependent A Reynolds, EM Anderson, A Vermeulen, Y Fedorov, K Robinson, ... Rna 12 (6), 988-993, 2006 | 445 | 2006 |
| The contributions of dsRNA structure to Dicer specificity and efficiency A Vermeulen, L Behlen, A Reynolds, A Wolfson, WS Marshall, ... Rna 11 (5), 674-682, 2005 | 399 | 2005 |
| Functional and hyperfunctional siRNA directed against Bcl-2 A Khvorova, A Reynolds, D Leake, W Marshall, S Scaringe, S Read US Patent 7,820,809, 2010 | 276 | 2010 |
| A protocol for designing siRNAs with high functionality and specificity A Birmingham, E Anderson, K Sullivan, A Reynolds, Q Boese, D Leake, ... Nature protocols 2 (9), 2068-2078, 2007 | 269 | 2007 |
| RNA interference S Jayasena, A Reynolds, A Khvorova US Patent App. 10/745,395, 2004 | 244 | 2004 |
| Modified polynucleotides for reducing off-target effects in RNA interference D Leake, A Reynolds, A Khvorova, W Marshall, PS Linsley US Patent 7,595,387, 2009 | 221 | 2009 |
| Experimental validation of the importance of seed complement frequency to siRNA specificity EM Anderson, A Birmingham, S Baskerville, A Reynolds, E Maksimova, ... Rna 14 (5), 853-861, 2008 | 182 | 2008 |
| Stabilized polynucleotides for use in RNA interference D Leake, A Reynolds, A Khvorova, W Marshall, S Scaringe US Patent App. 10/406,908, 2004 | 165 | 2004 |
| Mechanistic insights aid computational short interfering RNA design Q Boese, D Leake, A Reynolds, S Read, SA Scaringe, WS Marshall, ... Methods in enzymology 392, 73-96, 2005 | 136 | 2005 |
| Functional and hyperfunctional siRNA A Khvorova, A Reynolds, D Leake, W Marshall, S Scaringe US Patent 7,834,170, 2010 | 128 | 2010 |
| siRNA targeting DNA-damage-inducible transcript 4 (DDIT4) A Khvorova, A Reynolds, D Leake, W Marshall, S Read, S Scaringe US Patent 7,655,788, 2010 | 103* | 2010 |
