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Shane Grealish
Shane Grealish
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Generation of regionally specified neural progenitors and functional neurons from human embryonic stem cells under defined conditions
A Kirkeby, S Grealish, DA Wolf, J Nelander, J Wood, M Lundblad, ...
Cell reports 1 (6), 703-714, 2012
6482012
Generation of induced neurons via direct conversion in vivo
O Torper, U Pfisterer, DA Wolf, M Pereira, S Lau, J Jakobsson, ...
Proceedings of the National Academy of Sciences 110 (17), 7038-7043, 2013
4252013
Human ESC-Derived Dopamine Neurons Show Similar Preclinical Efficacy and Potency to Fetal Neurons when Grafted in a Rat Model of Parkinson’s Disease
S Grealish, E Diguet, A Kirkeby, B Mattsson, A Heuer, Y Bramoulle, ...
Cell stem cell 15 (5), 653-665, 2014
3962014
Predictive markers guide differentiation to improve graft outcome in clinical translation of hESC-based therapy for Parkinson’s Disease
A Kirkeby, S Nolbrant, K Tiklova, A Heuer, N Kee, T Cardoso, ...
Cell Stem Cell 20 (1), 135-148, 2017
2132017
The future of stem cell therapies for Parkinson disease
M Parmar, S Grealish, C Henchcliffe
Nature Reviews Neuroscience 21 (2), 103-115, 2020
1582020
In Vivo Reprogramming of Striatal NG2 Glia into Functional Neurons that Integrate into Local Host Circuitry
O Torper, DR Ottosson, M Pereira, S Lau, T Cardoso, S Grealish, ...
Cell reports 12 (3), 474-481, 2015
1572015
Characterisation of behavioural and neurodegenerative changes induced by intranigral 6‐hydroxydopamine lesions in a mouse model of Parkinson’s disease
S Grealish, B Mattsson, P Draxler, A Björklund
European Journal of Neuroscience 31 (12), 2266-2278, 2010
1472010
The A9 dopamine neuron component in grafts of ventral mesencephalon is an important determinant for recovery of motor function in a rat model of Parkinson’s disease
S Grealish, ME Jönsson, M Li, D Kirik, A Björklund, LH Thompson
Brain 133 (2), 482-495, 2010
1402010
Reconstruction of the nigrostriatal dopamine pathway in the adult mouse brain
LH Thompson, S Grealish, D Kirik, A Björklund
European Journal of Neuroscience 30 (4), 625-638, 2009
1302009
Synaptic inputs from stroke-injured brain to grafted human stem cell-derived neurons activated by sensory stimuli
D Tornero, O Tsupykov, M Granmo, C Rodriguez, M Grønning-Hansen, ...
Brain 140 (3), 692-706, 2017
1112017
Monosynaptic tracing using modified rabies virus reveals early and extensive circuit integration of human embryonic stem cell-derived neurons
S Grealish, A Heuer, T Cardoso, A Kirkeby, M Jönsson, J Johansson, ...
Stem cell reports 4 (6), 975-983, 2015
802015
GDNF is not required for catecholaminergic neuron survival in vivo
J Kopra, C Vilenius, S Grealish, MA Härma, K Varendi, J Lindholm, ...
Nature neuroscience 18 (3), 319-322, 2015
572015
Highly efficient generation of induced neurons from human fibroblasts that survive transplantation into the adult rat brain
M Pereira, U Pfisterer, D Rylander, O Torper, S Lau, M Lundblad, ...
Scientific reports 4, 6330, 2014
542014
hESC-Derived Dopaminergic Transplants Integrate into Basal Ganglia Circuitry in a Preclinical Model of Parkinson’s Disease
AF Adler, T Cardoso, S Nolbrant, B Mattsson, DB Hoban, U Jarl, ...
Cell Reports 28 (13), 3462-3473. e5, 2019
512019
IAP-Based Cell Sorting Results in Homogeneous Transplantable Dopaminergic Precursor Cells Derived from Human Pluripotent Stem Cells
D Lehnen, S Barral, T Cardoso, S Grealish, A Heuer, A Smiyakin, ...
Stem Cell Reports 9 (4), 1207-1220, 2017
432017
Unilateral axonal or terminal injection of 6-hydroxydopamine causes rapid-onset nigrostriatal degeneration and contralateral motor impairments in the rat
S Grealish, L Xie, M Kelly, E Dowd
Brain research bulletin 77 (5), 312-319, 2008
422008
Target‐specific forebrain projections and appropriate synaptic inputs of hESC‐derived dopamine neurons grafted to the midbrain of parkinsonian rats
T Cardoso, A Adler, B Mattsson, DB Hoban, S Nolbrant, ...
Journal of Comparative Neurology, 2018
392018
Region-specific restoration of striatal synaptic plasticity by dopamine grafts in experimental parkinsonism
D Rylander, V Bagetta, V Pendolino, E Zianni, S Grealish, F Gardoni, ...
Proceedings of the National Academy of Sciences 110 (46), E4375-E4384, 2013
292013
Brain repair and reprogramming: the route to clinical translation
S Grealish, J Drouin‐Ouellet, M Parmar
Journal of Internal Medicine 280 (3), 265-275, 2016
272016
Human foetal brain tissue as quality control when developing stem cells towards cell replacement therapy for neurological diseases
J Nelander, S Grealish, M Parmar
Neuroreport 24 (18), 1025-1030, 2013
122013
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