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Mika Kontro
Mika Kontro
Helsinki University Hospital and Institute for Molecular Medicine Finland
Geverifieerd e-mailadres voor helsinki.fi
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Individualized systems medicine strategy to tailor treatments for patients with chemorefractory acute myeloid leukemia
T Pemovska, M Kontro, B Yadav, H Edgren, S Eldfors, A Szwajda, ...
Cancer discovery 3 (12), 1416-1429, 2013
451*2013
Quantitative scoring of differential drug sensitivity for individually optimized anticancer therapies
B Yadav, T Pemovska, A Szwajda, E Kulesskiy, M Kontro, R Karjalainen, ...
Scientific reports 4 (1), 1-10, 2014
3212014
Axitinib effectively inhibits BCR-ABL1 (T315I) with a distinct binding conformation
T Pemovska, E Johnson, M Kontro, GA Repasky, J Chen, P Wells, ...
Nature 519 (7541), 102-105, 2015
2652015
Phenotype-based drug screening reveals association between venetoclax response and differentiation stage in acute myeloid leukemia
H Kuusanmäki, AM Leppä, P Pölönen, M Kontro, O Dufva, D Deb, ...
Haematologica 105 (3), 708, 2020
1302020
Novel activating STAT5B mutations as putative drivers of T-cell acute lymphoblastic leukemia
M Kontro, H Kuusanmäki, S Eldfors, T Burmeister, EI Andersson, ...
Leukemia 28 (8), 1738-1742, 2014
1262014
JAK1/2 and BCL2 inhibitors synergize to counteract bone marrow stromal cell–induced protection of AML
R Karjalainen, T Pemovska, M Popa, M Liu, KK Javarappa, MM Majumder, ...
Blood, The Journal of the American Society of Hematology 130 (6), 789-802, 2017
1242017
HOX gene expression predicts response to BCL-2 inhibition in acute myeloid leukemia
M Kontro, A Kumar, MM Majumder, S Eldfors, A Parsons, T Pemovska, ...
Leukemia 31 (2), 301-309, 2017
902017
Implementing a functional precision medicine tumor board for acute myeloid leukemia
D Malani, A Kumar, O Brück, M Kontro, B Yadav, M Hellesøy, ...
Cancer discovery 12 (2), 388-401, 2022
862022
Phase Ib study of the anti-TIM-3 antibody MBG453 in combination with decitabine in patients with high-risk myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML)
U Borate, J Esteve, K Porkka, S Knapper, N Vey, S Scholl, ...
Blood 134, 570, 2019
812019
Efficacy and safety of sabatolimab (MBG453) in combination with hypomethylating agents (HMAs) in patients (Pts) with very high/high-risk myelodysplastic syndrome (vHR/HR-MDS …
AM Brunner, J Esteve, K Porkka, S Knapper, E Traer, S Scholl, ...
Blood 138, 244, 2021
802021
Efficacy and safety of sabatolimab (MBG453) in combination with hypomethylating agents (HMAs) in patients with acute myeloid leukemia (AML) and high-risk myelodysplastic …
AM Brunner, J Esteve, K Porkka, S Knapper, N Vey, S Scholl, ...
Blood 136, 1-2, 2020
762020
Somatic MED12 mutations are associated with poor prognosis markers in chronic lymphocytic leukemia
K Kämpjärvi, TM Järvinen, T Heikkinen, AS Ruppert, L Senter, KW Hoag, ...
Oncotarget 6 (3), 1884, 2015
622015
Dasatinib and navitoclax act synergistically to target NUP98-NSD1+/FLT3-ITD+ acute myeloid leukemia
JL Kivioja, A Thanasopoulou, A Kumar, M Kontro, B Yadav, MM Majumder, ...
Leukemia 33 (6), 1360-1372, 2019
552019
Enhanced sensitivity to glucocorticoids in cytarabine-resistant AML
D Malani, A Murumägi, B Yadav, M Kontro, S Eldfors, A Kumar, ...
Leukemia 31 (5), 1187-1195, 2017
542017
Idelalisib sensitivity and mechanisms of disease progression in relapsed TCF3-PBX1 acute lymphoblastic leukemia
S Eldfors, H Kuusanmäki, M Kontro, MM Majumder, A Parsons, H Edgren, ...
Leukemia 31 (1), 51-57, 2017
522017
Somatic MED12 mutations in prostate cancer and uterine leiomyomas promote tumorigenesis through distinct mechanisms
K Kämpjärvi, NH Kim, S Keskitalo, AD Clark, P Von Nandelstadh, ...
The Prostate 76 (1), 22-31, 2016
442016
Elevated expression of S100A8 and S100A9 correlates with resistance to the BCL-2 inhibitor venetoclax in AML
R Karjalainen, M Liu, A Kumar, L He, D Malani, A Parsons, M Kontro, ...
Leukemia 33 (10), 2548-2553, 2019
352019
Novel drug candidates for blast phase chronic myeloid leukemia from high-throughput drug sensitivity and resistance testing
PO Pietarinen, T Pemovska, M Kontro, B Yadav, JP Mpindi, EI Andersson, ...
Blood cancer journal 5 (5), e309-e309, 2015
352015
Erythroid/megakaryocytic differentiation confers BCL-XL dependency and venetoclax resistance in acute myeloid leukemia
H Kuusanmäki, O Dufva, M Vähä-Koskela, AM Leppä, J Huuhtanen, ...
Blood 141 (13), 1610-1625, 2023
342023
In silico and preclinical drug screening identifies dasatinib as a targeted therapy for T-ALL
S Laukkanen, T Grönroos, P Pölönen, H Kuusanmäki, J Mehtonen, ...
Blood cancer journal 7 (9), e604-e604, 2017
322017
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