Umesh Jinwal
Umesh Jinwal
University of South Florida, Byrd Alzheimer’s Institute, College of Pharmacy
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Guidelines for the use and interpretation of assays for monitoring autophagy
DJ Klionsky, K Abdelmohsen, A Abe, MJ Abedin, H Abeliovich, ...
Autophagy 12 (1), 1-222, 2016
Chemical manipulation of hsp70 ATPase activity regulates tau stability
UK Jinwal, Y Miyata, J Koren, JR Jones, JH Trotter, L Chang, J O'Leary, ...
Journal of Neuroscience 29 (39), 12079-12088, 2009
Akt and CHIP coregulate tau degradation through coordinated interactions
CA Dickey, J Koren, YJ Zhang, Y Xu, UK Jinwal, MJ Birnbaum, B Monks, ...
Proceedings of the National Academy of Sciences 105 (9), 3622-3627, 2008
Tau accumulation activates the unfolded protein response by impairing endoplasmic reticulum-associated degradation
JF Abisambra, UK Jinwal, LJ Blair, JC O'Leary, Q Li, S Brady, L Wang, ...
The Journal of Neuroscience 33 (22), 9498-9507, 2013
The Hsp90 cochaperone, FKBP51, increases Tau stability and polymerizes microtubules
UK Jinwal, J Koren, SI Borysov, AB Schmid, JF Abisambra, LJ Blair, ...
The Journal of Neuroscience 30 (2), 591-599, 2010
Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden
JC O'Leary, Q Li, P Marinec, LJ Blair, EE Congdon, AG Johnson, ...
Molecular neurodegeneration 5 (1), 45, 2010
Allosteric drugs: the interaction of antitumor compound MKT-077 with human Hsp70 chaperones
A Rousaki, Y Miyata, UK Jinwal, CA Dickey, JE Gestwicki, ERP Zuiderweg
Journal of molecular biology 411 (3), 614-632, 2011
Trafficking CD11b-positive blood cells deliver therapeutic genes to the brain of amyloid-depositing transgenic mice
L Lebson, K Nash, S Kamath, D Herber, N Carty, DC Lee, Q Li, ...
The Journal of Neuroscience 30 (29), 9651-9658, 2010
Chaperone signalling complexes in Alzheimer's disease
J Koren, UK Jinwal, DC Lee, JR Jones, CL Shults, AG Johnson, ...
Journal of cellular and molecular medicine 13 (4), 619-630, 2009
1, 25-Dihydroxyvitamin D3 suppresses telomerase expression and human cancer growth through microRNA-498
R Kasiappan, Z Shen, KW Anfernee, U Jinwal, J Tang, P Lungchukiet, ...
Journal of Biological Chemistry 287 (49), 41297-41309, 2012
Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau
J Abisambra, UK Jinwal, Y Miyata, J Rogers, L Blair, X Li, SP Seguin, ...
Biological psychiatry 74 (5), 367-374, 2013
Imbalance of Hsp70 family variants fosters tau accumulation
UK Jinwal, E Akoury, JF Abisambra, JC O'Leary, AD Thompson, LJ Blair, ...
The FASEB Journal 27 (4), 1450-1459, 2013
Synthesis and initial evaluation of YM-08, a blood-brain barrier permeable derivative of the heat shock protein 70 (Hsp70) inhibitor MKT-077, which reduces tau levels
Y Miyata, X Li, HF Lee, UK Jinwal, SR Srinivasan, SP Seguin, ZT Young, ...
ACS chemical neuroscience 4 (6), 930-939, 2013
A new anti-depressive strategy for the elderly: ablation of FKBP5/FKBP51
JC O'Leary III, S Dharia, LJ Blair, S Brady, AG Johnson, M Peters, ...
PloS one 6 (9), e24840, 2011
Phosphorylation dynamics regulate Hsp27-mediated rescue of neuronal plasticity deficits in tau transgenic mice
JF Abisambra, LJ Blair, SE Hill, JR Jones, C Kraft, J Rogers, J Koren, ...
The Journal of Neuroscience 30 (46), 15374-15382, 2010
Natural products as a rich source of tau-targeting drugs for Alzheimer's disease
L Calcul, B Zhang, UK Jinwal, CA Dickey, BJ Baker
Future medicinal chemistry 4 (13), 1751-1761, 2012
Facilitating Akt clearance via manipulation of Hsp70 activity and levels
J Koren, UK Jinwal, Y Jin, J O'Leary, JR Jones, AG Johnson, LJ Blair, ...
Journal of Biological Chemistry 285 (4), 2498-2505, 2010
Cysteine reactivity distinguishes redox sensing by the heat-inducible and constitutive forms of heat shock protein 70
Y Miyata, JN Rauch, UK Jinwal, AD Thompson, S Srinivasan, CA Dickey, ...
Chemistry & biology 19 (11), 1391-1399, 2012
Hsc70 rapidly engages tau after microtubule destabilization
UK Jinwal, JC O'Leary, SI Borysov, JR Jones, Q Li, J Koren, JF Abisambra, ...
Journal of Biological Chemistry 285 (22), 16798-16805, 2010
Aging analysis reveals slowed tau turnover and enhanced stress response in a mouse model of tauopathy
C Dickey, C Kraft, U Jinwal, J Koren, A Johnson, L Anderson, L Lebson, ...
The American journal of pathology 174 (1), 228-238, 2009
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