| Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics A Sottoriva, I Spiteri, SGM Piccirillo, A Touloumis, VP Collins, JC Marioni, ... Proceedings of the National Academy of Sciences 110 (10), 4009-4014, 2013 | 1278 | 2013 |
| ANTARES: the first undersea neutrino telescope M Ageron, JA Aguilar, I Al Samarai, A Albert, F Ameli, M André, ... Nuclear Instruments and Methods in Physics Research Section A: Accelerators …, 2011 | 747 | 2011 |
| A Big Bang model of human colorectal tumor growth A Sottoriva, H Kang, Z Ma, TA Graham, MP Salomon, J Zhao, P Marjoram, ... Nature genetics 47 (3), 209-216, 2015 | 708 | 2015 |
| Patient-derived organoids model treatment response of metastatic gastrointestinal cancers G Vlachogiannis, S Hedayat, A Vatsiou, Y Jamin, J Fernández-Mateos, ... Science 359 (6378), 920-926, 2018 | 502 | 2018 |
| Identification of neutral tumor evolution across cancer types MJ Williams, B Werner, CP Barnes, TA Graham, A Sottoriva Nature genetics 48 (3), 238-244, 2016 | 405 | 2016 |
| The shaping and functional consequences of the microRNA landscape in breast cancer H Dvinge, A Git, S Gräf, M Salmon-Divon, C Curtis, A Sottoriva, Y Zhao, ... Nature 497 (7449), 378-382, 2013 | 401 | 2013 |
| Defining stem cell dynamics in models of intestinal tumor initiation L Vermeulen, E Morrissey, M Van Der Heijden, AM Nicholson, A Sottoriva, ... Science 342 (6161), 995-998, 2013 | 296 | 2013 |
| Classifying the evolutionary and ecological features of neoplasms CC Maley, A Aktipis, TA Graham, A Sottoriva, AM Boddy, M Janiszewska, ... Nature Reviews Cancer 17 (10), 605, 2017 | 200 | 2017 |
| Cancer stem cell tumor model reveals invasive morphology and increased phenotypical heterogeneity A Sottoriva, JJC Verhoeff, T Borovski, SK McWeeney, L Naumov, ... Cancer research 70 (1), 46-56, 2010 | 193 | 2010 |
| Cancer evolution and the limits of predictability in precision cancer medicine KA Lipinski, LJ Barber, MN Davies, M Ashenden, A Sottoriva, M Gerlinger Trends in cancer 2 (1), 49-63, 2016 | 186 | 2016 |
| A multiphysics and multiscale software environment for modeling astrophysical systems SP Zwart, S McMillan, S Harfst, D Groen, M Fujii, BÓ Nualláin, E Glebbeek, ... New Astronomy 14 (4), 369-378, 2009 | 182 | 2009 |
| Resolving genetic heterogeneity in cancer S Turajlic, A Sottoriva, T Graham, C Swanton Nature Reviews Genetics 20 (7), 404-416, 2019 | 144 | 2019 |
| Quantification of subclonal selection in cancer from bulk sequencing data MJ Williams, B Werner, T Heide, C Curtis, CP Barnes, A Sottoriva, ... Nature genetics 50 (6), 895-903, 2018 | 128 | 2018 |
| Longitudinal liquid biopsy and mathematical modeling of clonal evolution forecast time to treatment failure in the PROSPECT-C phase II colorectal cancer clinical trial KH Khan, D Cunningham, B Werner, G Vlachogiannis, I Spiteri, T Heide, ... Cancer discovery 8 (10), 1270-1285, 2018 | 105 | 2018 |
| Between-region genetic divergence reflects the mode and tempo of tumor evolution R Sun, Z Hu, A Sottoriva, TA Graham, A Harpak, Z Ma, JM Fischer, ... Nature genetics 49 (7), 1015, 2017 | 90 | 2017 |
| Current challenges in glioblastoma: intratumour heterogeneity, residual disease, and models to predict disease recurrence HP Ellis, M Greenslade, B Powell, I Spiteri, A Sottoriva, KM Kurian Frontiers in oncology 5, 251, 2015 | 87 | 2015 |
| Single-molecule genomic data delineate patient-specific tumor profiles and cancer stem cell organization A Sottoriva, I Spiteri, D Shibata, C Curtis, S Tavaré Cancer research 73 (1), 41-49, 2013 | 84 | 2013 |
| Detecting repeated cancer evolution from multi-region tumor sequencing data G Caravagna, Y Giarratano, D Ramazzotti, I Tomlinson, TA Graham, ... Nature methods 15 (9), 707-714, 2018 | 68 | 2018 |
| Modeling evolutionary dynamics of epigenetic mutations in hierarchically organized tumors A Sottoriva, L Vermeulen, S Tavaré PLoS Comput Biol 7 (5), e1001132, 2011 | 66 | 2011 |
| EGFRvIII mutations can emerge as late and heterogenous events in glioblastoma development and promote angiogenesis through Src activation E Eskilsson, GV Rosland, KM Talasila, S Knappskog, O Keunen, ... Neuro-oncology 18 (12), 1644-1655, 2016 | 59 | 2016 |
Trevor A GrahamProfessor of Cancer Evolution, Barts Cancer Institute, QMULVerified email at qmul.ac.uk
