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Xaralabos (Bob) Varelas
Xaralabos (Bob) Varelas
Professor, Department of Biochemistry and Cell Biology, Boston University School of Medicine
Geverifieerd e-mailadres voor bu.edu - Homepage
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The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway
X Varelas, P Samavarchi-Tehrani, M Narimatsu, A Weiss, K Cockburn, ...
Developmental cell 19 (6), 831-844, 2010
7832010
TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal
X Varelas, R Sakuma, P Samavarchi-Tehrani, R Peerani, BM Rao, ...
Nature cell biology 10 (7), 837-848, 2008
7502008
Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis
F Liu, D Lagares, KM Choi, L Stopfer, A Marinković, V Vrbanac, CK Probst, ...
American Journal of Physiology-Lung Cellular and Molecular Physiology 308 (4 …, 2015
7172015
The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease
X Varelas
Development 141 (8), 1614-1626, 2014
6952014
The Hippo pathway regulates Wnt/β-catenin signaling
X Varelas, BW Miller, R Sopko, S Song, A Gregorieff, FA Fellouse, ...
Developmental cell 18 (4), 579-591, 2010
6232010
Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine
A Dey, X Varelas, KL Guan
Nature reviews Drug discovery 19 (7), 480-494, 2020
4292020
Switch enhancers interpret TGF-β and Hippo signaling to control cell fate in human embryonic stem cells
TA Beyer, A Weiss, Y Khomchuk, K Huang, AA Ogunjimi, X Varelas, ...
Cell reports 5 (6), 1611-1624, 2013
3032013
The transcriptional regulators TAZ and YAP direct transforming growth factor β-induced tumorigenic phenotypes in breast cancer cells*♦
SE Hiemer, AD Szymaniak, X Varelas
Journal of Biological Chemistry 289 (19), 13461-13474, 2014
2652014
An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme
DF Ceccarelli, X Tang, B Pelletier, S Orlicky, W Xie, V Plantevin, ...
Cell 145 (7), 1075-1087, 2011
2482011
The hippo pathway effector Yap controls patterning and differentiation of airway epithelial progenitors
JE Mahoney, M Mori, AD Szymaniak, X Varelas, WV Cardoso
Developmental cell 30 (2), 137-150, 2014
2342014
Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis
D Lagares, A Santos, PE Grasberger, F Liu, CK Probst, RA Rahimi, ...
Science translational medicine 9 (420), eaal3765, 2017
1832017
Selective YAP/TAZ inhibition in fibroblasts via dopamine receptor D1 agonism reverses fibrosis
AJ Haak, E Kostallari, D Sicard, G Ligresti, KM Choi, N Caporarello, ...
Science translational medicine 11 (516), eaau6296, 2019
1562019
Crumbs3-mediated polarity directs airway epithelial cell fate through the Hippo pathway effector Yap
AD Szymaniak, JE Mahoney, WV Cardoso, X Varelas
Developmental cell 34 (3), 283-296, 2015
1522015
Notch3-Jagged signaling controls the pool of undifferentiated airway progenitors
M Mori, JE Mahoney, MR Stupnikov, JR Paez-Cortez, AD Szymaniak, ...
Development 142 (2), 258-267, 2015
1522015
Notch3-Jagged signaling controls the pool of undifferentiated airway progenitors
M Mori, JE Mahoney, MR Stupnikov, JR Paez-Cortez, AD Szymaniak, ...
Development 142 (2), 258-267, 2015
1522015
Integrating developmental signals: a Hippo in the (path) way
A Mauviel, F Nallet-Staub, X Varelas
Oncogene 31 (14), 1743-1756, 2012
1472012
Systematic morphological profiling of human gene and allele function via Cell Painting
MH Rohban, S Singh, X Wu, JB Berthet, MA Bray, Y Shrestha, X Varelas, ...
Elife 6, e24060, 2017
1262017
A YAP/TAZ-regulated molecular signature is associated with oral squamous cell carcinoma
SE Hiemer, L Zhang, VK Kartha, TS Packer, M Almershed, V Noonan, ...
Molecular Cancer Research 13 (6), 957-968, 2015
1252015
The Hippo pathway effectors TAZ/YAP regulate dicer expression and microRNA biogenesis through Let-7
SG Chaulk, VJ Lattanzi, SE Hiemer, RP Fahlman, X Varelas
Journal of Biological Chemistry 289 (4), 1886-1891, 2014
1202014
Stem cell regulation by the Hippo pathway
SE Hiemer, X Varelas
Biochimica et Biophysica Acta (BBA)-General Subjects 1830 (2), 2323-2334, 2013
1172013
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Artikelen 1–20