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Ying-Duo Gao
Ying-Duo Gao
Structural Chemistry, Merck & Co., Inc.
Adresse e-mail validée de merck.com
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Two tarantula peptides inhibit activation of multiple sodium channels
RE Middleton, VA Warren, RL Kraus, JC Hwang, CJ Liu, G Dai, ...
Biochemistry 41 (50), 14734-14747, 2002
2822002
Succinic acids as potent inhibitors of plasmid-borne IMP-1 metallo-β-lactamase
JH Toney, GG Hammond, PMD Fitzgerald, N Sharma, JM Balkovec, ...
Journal of Biological Chemistry 276 (34), 31913-31918, 2001
2492001
Omarigliptin (MK-3102): a novel long-acting DPP-4 inhibitor for once-weekly treatment of type 2 diabetes
T Biftu, R Sinha-Roy, P Chen, X Qian, D Feng, JT Kuethe, G Scapin, ...
Journal of Medicinal Chemistry 57 (8), 3205-3212, 2014
1862014
Ligand activation domain of human orphan growth hormone (GH) secretagogue receptor (GHS-R) conserved from Pufferfish to humans
OC Palyha, SD Feighner, CP Tan, KK McKee, DL Hreniuk, YD Gao, ...
Molecular Endocrinology 14 (1), 160-169, 2000
1632000
Potassium channels: from scorpion venoms to high-resolution structure
ML Garcia, YD Gao, OB McManus, GJ Kaczorowski
Toxicon 39 (6), 739-748, 2001
1482001
Resiniferatoxin binds to the capsaicin receptor (TRPV1) near the extracellular side of the S4 transmembrane domain
MZ Chou, T Mtui, YD Gao, M Kohler, RE Middleton
Biochemistry 43 (9), 2501-2511, 2004
1392004
Mimicry of erythropoietin by a nonpeptide molecule
SA Qureshi, RM Kim, Z Konteatis, DE Biazzo, H Motamedi, R Rodrigues, ...
Proceedings of the National Academy of Sciences 96 (21), 12156-12161, 1999
1311999
Drug-like density: a method of quantifying the “bindability” of a protein target based on a very large set of pockets and drug-like ligands from the Protein Data Bank
RP Sheridan, VN Maiorov, MK Holloway, WD Cornell, YD Gao
Journal of chemical information and modeling 50 (11), 2029-2040, 2010
1172010
Attenuating pregnane X receptor (PXR) activation: a molecular modelling approach
YD Gao, SH Olson, JM Balkovec, Y Zhu, I Royo, J Yabut, R Evers, EY Tan, ...
Xenobiotica 37 (2), 124-138, 2007
1142007
Fullerenes with four-membered rings
YD Gao, WC Herndon
Journal of the American Chemical Society 115 (18), 8459-8460, 1993
921993
Interaction of agitoxin2, charybdotoxin, and iberiotoxin with potassium channels: selectivity between voltage‐gated and Maxi‐K channels
YD Gao, ML Garcia
Proteins: Structure, Function, and Bioinformatics 52 (2), 146-154, 2003
872003
A comparative study of the binding properties, dipeptidyl peptidase‐4 (DPP‐4) inhibitory activity and glucose‐lowering efficacy of the DPP‐4 inhibitors alogliptin, linagliptin …
JP Berger, R SinhaRoy, A Pocai, TM Kelly, G Scapin, YD Gao, KAD Pryor, ...
Endocrinology, diabetes & metabolism 1 (1), e00002, 2018
802018
Tubular graphic carbon structures
YD Gao, WC Herndon
Molecular Physics 77 (3), 585-599, 1992
691992
Binding of correolide to the Kv1. 3 potassium channel: characterization of the binding domain by site-directed mutagenesis
M Hanner, B Green, YD Gao, WA Schmalhofer, M Matyskiela, DJ Durand, ...
Biochemistry 40 (39), 11687-11697, 2001
672001
(3R)-4-[(3R)-3-Amino-4-(2, 4, 5-trifluorophenyl) butanoyl]-3-(2, 2, 2-trifluoroethyl)-1, 4-diazepan-2-one, a selective dipeptidyl peptidase IV inhibitor for the treatment of …
T Biftu, D Feng, X Qian, GB Liang, G Kieczykowski, G Eiermann, H He, ...
Bioorganic & Medicinal Chemistry Letters 17 (1), 49-52, 2007
612007
Mathematical and chemical analysis of Wiener's polarity number
H Hosoya, Y Gao
Topology in Chemistry, 38-57, 2002
532002
How do the polycyclic aromatic hydrocarbons approach infinity?
H Hosoya, H Kumazaki, K Chida, M Ohuchi, YD Gao
Pure and applied chemistry 62 (3), 445-450, 1990
521990
Functional mapping of the transient receptor potential vanilloid 1 intracellular binding site
DM Johnson, EM Garrett, R Rutter, TP Bonnert, YD Gao, RE Middleton, ...
Molecular pharmacology 70 (3), 1005-1012, 2006
442006
Discovery of 8-Amino-imidazo[1,5-a]pyrazines as Reversible BTK Inhibitors for the Treatment of Rheumatoid Arthritis
J Liu, D Guiadeen, A Krikorian, X Gao, J Wang, SB Boga, AB Alhassan, ...
ACS Medicinal Chemistry Letters 7 (2), 198-203, 2016
432016
Novel tetrahydropyran analogs as dipeptidyl peptidase IV inhibitors: profile of clinical candidate (2R, 3S, 5R)-2-(2, 5-difluorophenyl)-5-[2-(methylsulfonyl)-2, 6 …
T Biftu, X Qian, P Chen, D Feng, G Scapin, YD Gao, J Cox, RS Roy, ...
Bioorganic & medicinal chemistry letters 23 (19), 5361-5366, 2013
422013
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