| Auto-antibodies against type I IFNs in patients with life-threatening COVID-19 P Bastard, LB Rosen, Q Zhang, E Michailidis, HH Hoffmann, Y Zhang, ... Science, 2020 | 2454 | 2020 |
| Inborn errors of type I IFN immunity in patients with life-threatening COVID-19 Q Zhang, P Bastard, Z Liu, J Le Pen, M Moncada-Velez, J Chen, M Ogishi, ... Science, 2020 | 2130 | 2020 |
| 30 years of NF-κB: a blossoming of relevance to human pathobiology Q Zhang, MJ Lenardo, D Baltimore Cell 168 (1-2), 37-57, 2017 | 1784 | 2017 |
| Combined Immunodeficiency Associated with DOCK8 Mutations Q Zhang, JC Davis, IT Lamborn, AF Freeman, H Jing, AJ Favreau, ... New England Journal of Medicine 361 (21), 2046-2055, 2009 | 775 | 2009 |
| Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy B Lo, K Zhang, W Lu, L Zheng, Q Zhang, C Kanellopoulou, Y Zhang, Z Liu, ... Science 349 (6246), 436-440, 2015 | 674 | 2015 |
| Autoantibodies neutralizing type I IFNs are present in~ 4% of uninfected individuals over 70 years old and account for~ 20% of COVID-19 deaths P Bastard, A Gervais, T Le Voyer, J Rosain, Q Philippot, J Manry, ... Science immunology 6 (62), eabl4340, 2021 | 438 | 2021 |
| X-linked recessive TLR7 deficiency in~ 1% of men under 60 years old with life-threatening COVID-19 T Asano, B Boisson, F Onodi, D Matuozzo, M Moncada-Velez, ... Science immunology 6 (62), eabl4348, 2021 | 327 | 2021 |
| A global effort to define the human genetics of protective immunity to SARS-CoV-2 infection JL Casanova, HC Su, L Abel, A Aiuti, S Almuhsen, AA Arias, P Bastard, ... Cell 181 (6), 1194-1199, 2020 | 253 | 2020 |
| Human genetic and immunological determinants of critical COVID-19 pneumonia Q Zhang, P Bastard, A Cobat, JL Casanova Nature 603 (7902), 587-598, 2022 | 221 | 2022 |
| Life-threatening influenza pneumonitis in a child with inherited IRF9 deficiencyIRF9 deficiency N Hernandez, I Melki, H Jing, T Habib, SSY Huang, J Danielson, T Kula, ... The Journal of experimental medicine 215 (10), 2567-2585, 2018 | 176 | 2018 |
| Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19 MGP van der Wijst, SE Vazquez, GC Hartoularos, P Bastard, T Grant, ... Science translational medicine 13 (612), eabh2624, 2021 | 171 | 2021 |
| Tuberculosis and impaired IL-23–dependent IFN-γ immunity in humans homozygous for a common TYK2 missense variant S Boisson-Dupuis, N Ramirez-Alejo, Z Li, E Patin, G Rao, G Kerner, ... Science immunology 3 (30), eaau8714, 2018 | 169 | 2018 |
| DOCK8 regulates lymphocyte shape integrity for skin antiviral immunity Q Zhang, CG Dove, JL Hor, HM Murdock, DM Strauss-Albee, JA Garcia, ... Journal of Experimental Medicine 211 (13), 2549-2566, 2014 | 166 | 2014 |
| Severe influenza pneumonitis in children with inherited TLR3 deficiency HK Lim, SXL Huang, J Chen, G Kerner, O Gilliaux, P Bastard, K Dobbs, ... Journal of Experimental Medicine 216 (9), 2038-2056, 2019 | 155 | 2019 |
| Inherited IFNAR1 deficiency in otherwise healthy patients with adverse reaction to measles and yellow fever live vaccines N Hernandez, G Bucciol, L Moens, J Le Pen, M Shahrooei, E Goudouris, ... Journal of Experimental Medicine 216 (9), 2057-2070, 2019 | 153 | 2019 |
| Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever live attenuated vaccine P Bastard, E Michailidis, HH Hoffmann, M Chbihi, T Le Voyer, J Rosain, ... Journal of Experimental Medicine 218 (4), 2021 | 143 | 2021 |
| Life-threatening COVID-19: defective interferons unleash excessive inflammation Q Zhang, P Bastard, A Bolze, E Jouanguy, SY Zhang, CHG Effort, A Cobat, ... Med 1 (1), 14-20, 2020 | 140 | 2020 |
| DOCK8 is essential for T‐cell survival and the maintenance of CD8+ T‐cell memory T Lambe, G Crawford, AL Johnson, TL Crockford, T Bouriez‐Jones, ... European journal of immunology 41 (12), 3423-3435, 2011 | 135 | 2011 |
| SARS-CoV-2 induces human plasmacytoid predendritic cell diversification via UNC93B and IRAK4 F Onodi, L Bonnet-Madin, L Meertens, L Karpf, J Poirot, SY Zhang, ... Journal of Experimental Medicine 218 (4), 2021 | 113 | 2021 |
| Genetic, clinical, and laboratory markers for DOCK8 immunodeficiency syndrome Q Zhang, JC Davis, CG Dove, HC Su Disease markers 29 (3, 4), 131-139, 2010 | 105 | 2010 |
Jean-Laurent Casanova, MD, PhDProfessor, Rockefeller University; Investigator, Howard Hughes Medical Institute; Head, St. GilesVerified email at rockefeller.edu
