| The role of inflammation in insulitis and β-cell loss in type 1 diabetes DL Eizirik, ML Colli, F Ortis Nature Reviews Endocrinology 5 (4), 219-226, 2009 | 1160 | 2009 |
| Initiation and execution of lipotoxic ER stress in pancreatic β-cells DA Cunha, P Hekerman, L Ladrière, A Bazarra-Castro, F Ortis, ... Journal of cell science 121 (14), 2308-2318, 2008 | 716 | 2008 |
| Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in … AK Cardozo, F Ortis, J Storling, YM Feng, J Rasschaert, M Tonnesen, ... Diabetes 54 (2), 452-461, 2005 | 616 | 2005 |
| The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines DL Eizirik, M Sammeth, T Bouckenooghe, G Bottu, G Sisino, ... PLoS genetics 8 (3), e1002552, 2012 | 501 | 2012 |
| Selective inhibition of eukaryotic translation initiation factor 2α dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic β-cell … M Cnop, L Ladriere, P Hekerman, F Ortis, AK Cardozo, Z Dogusan, ... Journal of Biological Chemistry 282 (6), 3989-3997, 2007 | 346 | 2007 |
| Glucagon-like peptide-1 agonists protect pancreatic β-cells from lipotoxic endoplasmic reticulum stress through upregulation of BiP and JunB DA Cunha, L Ladriere, F Ortis, M Igoillo-Esteve, EN Gurzov, R Lupi, ... Diabetes 58 (12), 2851-2862, 2009 | 267 | 2009 |
| Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes M Igoillo-Esteve, L Marselli, DA Cunha, L Ladrière, F Ortis, FA Grieco, ... Diabetologia 53, 1395-1405, 2010 | 257 | 2010 |
| Induction of nuclear factor-κB and its downstream genes by TNF-α and IL-1β has a pro-apoptotic role in pancreatic beta cells F Ortis, P Pirot, N Naamane, AY Kreins, J Rasschaert, F Moore, E Theatre, ... Diabetologia 51, 1213-1225, 2008 | 216 | 2008 |
| Signaling by IL-1β+ IFN-γ and ER stress converge on DP5/Hrk activation: a novel mechanism for pancreatic β-cell apoptosis EN Gurzov, F Ortis, DA Cunha, G Gosset, M Li, AK Cardozo, DL Eizirik Cell Death & Differentiation 16 (11), 1539-1550, 2009 | 190 | 2009 |
| STAT1 is a master regulator of pancreatic β-cell apoptosis and islet inflammation F Moore, N Naamane, ML Colli, T Bouckenooghe, F Ortis, EN Gurzov, ... Journal of Biological Chemistry 286 (2), 929-941, 2011 | 187 | 2011 |
| Cytokines interleukin-1β and tumor necrosis factor-α regulate different transcriptional and alternative splicing networks in primary β-cells F Ortis, N Naamane, D Flamez, L Ladriere, F Moore, DA Cunha, ML Colli, ... Diabetes 59 (2), 358-374, 2010 | 187 | 2010 |
| Cytokine-induced proapoptotic gene expression in insulin-producing cells is related to rapid, sustained, and nonoscillatory nuclear factor-κB activation F Ortis, AK Cardozo, D Crispim, J Storling, T Mandrup-Poulsen, DL Eizirik Molecular Endocrinology 20 (8), 1867-1879, 2006 | 175 | 2006 |
| p53 up-regulated modulator of apoptosis (PUMA) activation contributes to pancreatic β-cell apoptosis induced by proinflammatory cytokines and endoplasmic reticulum stress EN Gurzov, CM Germano, DA Cunha, F Ortis, JM Vanderwinden, ... Journal of Biological Chemistry 285 (26), 19910-19920, 2010 | 140 | 2010 |
| Sustained production of spliced X-box binding protein 1 (XBP1) induces pancreatic beta cell dysfunction and apoptosis F Allagnat, F Christulia, F Ortis, P Pirot, S Lortz, S Lenzen, DL Eizirik, ... Diabetologia 53, 1120-1130, 2010 | 135 | 2010 |
| Cell-permeable peptides induce dose-and length-dependent cytotoxic effects AK Cardozo, V Buchillier, M Mathieu, J Chen, F Ortis, L Ladrière, ... Biochimica et Biophysica Acta (BBA)-Biomembranes 1768 (9), 2222-2234, 2007 | 135 | 2007 |
| Loss of PPARγ in immune cells impairs the ability of abscisic acid to improve insulin sensitivity by suppressing monocyte chemoattractant protein-1 expression and macrophage … AJ Guri, R Hontecillas, G Ferrer, O Casagran, U Wankhade, AM Noble, ... The Journal of nutritional biochemistry 19 (4), 216-228, 2008 | 133 | 2008 |
| Transcriptional regulation of the endoplasmic reticulum stress gene chop in pancreatic insulin-producing cells P Pirot, F Ortis, M Cnop, Y Ma, LM Hendershot, DL Eizirik, AK Cardozo Diabetes 56 (4), 1069-1077, 2007 | 133 | 2007 |
| MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic β-cell responses to the viral by-product double-stranded RNA ML Colli, F Moore, EN Gurzov, F Ortis, DL Eizirik Human molecular genetics 19 (1), 135-146, 2010 | 108 | 2010 |
| Endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation K Meyerovich, F Ortis, F Allagnat, AK Cardozo J Mol Endocrinol 57 (1), R1-R17, 2016 | 91 | 2016 |
| Huntingtin-interacting protein 14 is a type 1 diabetes candidate protein regulating insulin secretion and β-cell apoptosis LA Berchtold, ZM Størling, F Ortis, K Lage, C Bang-Berthelsen, ... Proceedings of the National Academy of Sciences 108 (37), E681-E688, 2011 | 80 | 2011 |
