Eckhard Mandelkow
Eckhard Mandelkow
DZNE & Max-Planck Institute
Verified email at - Homepage
Cited by
Cited by
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif, A Abdoli, S Abel, ...
autophagy 17 (1), 1-382, 2021
Tau in physiology and pathology
Y Wang, E Mandelkow
Nature reviews neuroscience 17 (1), 22, 2016
Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress
K Stamer, R Vogel, E Thies, E Mandelkow, EM Mandelkow
The Journal of cell biology 156 (6), 1051-1063, 2002
Assembly of τ protein into Alzheimer paired helical filaments depends on a local sequence motif (306VQIVYK311) forming β structure
M Von Bergen, P Friedhoff, J Biernat, J Heberle, EM Mandelkow, ...
Proceedings of the National Academy of Sciences 97 (10), 5129-5134, 2000
Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease
JC Augustinack, A Schneider, EM Mandelkow, BT Hyman
Acta neuropathologica 103 (1), 26-35, 2002
MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption
G Drewes, A Ebneth, U Preuss, EM Mandelkow, E Mandelkow
Cell 89 (2), 297-308, 1997
Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: implications for Alzheimer's disease
A Ebneth, R Godemann, K Stamer, S Illenberger, B Trinczek, ...
The Journal of cell biology 143 (3), 777-794, 1998
A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads
F Braak, H Braak, EM Mandelkow
Acta neuropathologica 87 (6), 554-567, 1994
Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: distinction between PHF-like immunoreactivity and microtubule binding
J Biernat, N Gustke, G Drewes, E Mandelkow
Neuron 11 (1), 153-163, 1993
Indirubins inhibit glycogen synthase kinase-3β and CDK5/P25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease: a property common to most …
S Leclerc, M Garnier, R Hoessel, D Marko, JA Bibb, GL Snyder, ...
Journal of Biological Chemistry 276 (1), 251-260, 2001
Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer‐like state.
G Drewes, B Lichtenberg‐Kraag, F Döring, EM Mandelkow, J Biernat, ...
The EMBO journal 11 (6), 2131-2138, 1992
Glycogen synthase kinase-3 and the Alzheimer-like state of microtubule-associated protein tau
EM Mandelkow, G Drewes, J Biernat, N Gustke, J Van Lint, ...
FEBS letters 314 (3), 315-321, 1992
Biochemistry and cell biology of tau protein in neurofibrillary degeneration
EM Mandelkow, E Mandelkow
Cold Spring Harbor perspectives in medicine 2 (7), a006247, 2012
Domains of tau protein and interactions with microtubules
N Gustke, B Trinczek, J Biernat, EM Mandelkow, E Mandelkow
Biochemistry 33 (32), 9511-9522, 1994
Structural studies of tau protein and Alzheimer paired helical filaments show no evidence for beta-structure.
O Schweers, E Schönbrunn-Hanebeck, A Marx, E Mandelkow
Journal of Biological Chemistry 269 (39), 24290-24297, 1994
Microtubule dynamics and microtubule caps: a time-resolved cryo-electron microscopy study.
EM Mandelkow, E Mandelkow, RA Milligan
The Journal of cell biology 114 (5), 977-991, 1991
Aβ oligomers cause localized Ca2+ elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines
H Zempel, E Thies, E Mandelkow, EM Mandelkow
Journal of Neuroscience 30 (36), 11938-11950, 2010
Tau in Alzheimer's disease
EM Mandelkow, E Mandelkow
Trends in cell biology 8 (11), 425-427, 1998
Abnormal Alzheimer‐like phosphorylation of tau‐protein by cyclin‐dependent kinases cdk2 and cdk5
K Baumann, EM Mandelkow, J Biernat, H Piwnica-Worms, E Mandelkow
FEBS letters 336 (3), 417-424, 1993
Microtubules and microtubule-associated proteins
E Mandelkow, EM Mandelkow
Current opinion in cell biology 7 (1), 72-81, 1995
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