| Computational redesign of protein-protein interaction specificity T Kortemme, LA Joachimiak, AN Bullock, AD Schuler, BL Stoddard, ... Nature structural & molecular biology 11 (4), 371-379, 2004 | 391 | 2004 |
| The molecular architecture of the eukaryotic chaperonin TRiC/CCT A Leitner, LA Joachimiak, A Bracher, L Mönkemeyer, T Walzthoeni, ... Structure 20 (5), 814-825, 2012 | 331 | 2012 |
| The chaperonin TRiC blocks a huntingtin sequence element that promotes the conformational switch to aggregation S Tam, C Spiess, W Auyeung, L Joachimiak, B Chen, MA Poirier, ... Nature structural & molecular biology 16 (12), 1279-1285, 2009 | 298 | 2009 |
| Chemical cross-linking/mass spectrometry targeting acidic residues in proteins and protein complexes A Leitner, LA Joachimiak, P Unverdorben, T Walzthoeni, J Frydman, ... Proceedings of the National Academy of Sciences 111 (26), 9455-9460, 2014 | 277 | 2014 |
| Inert and seed-competent tau monomers suggest structural origins of aggregation H Mirbaha, D Chen, OA Morazova, KM Ruff, AM Sharma, X Liu, ... Elife 7, e36584, 2018 | 259 | 2018 |
| A de novo protein binding pair by computational design and directed evolution J Karanicolas, JE Corn, I Chen, LA Joachimiak, O Dym, SH Peck, ... Molecular cell 42 (2), 250-260, 2011 | 199 | 2011 |
| Computational design of a new hydrogen bond network and at least a 300-fold specificity switch at a protein− protein interface LA Joachimiak, T Kortemme, BL Stoddard, D Baker Journal of molecular biology 361 (1), 195-208, 2006 | 179 | 2006 |
| The structural basis of substrate recognition by the eukaryotic chaperonin TRiC/CCT LA Joachimiak, T Walzthoeni, CW Liu, R Aebersold, J Frydman Cell 159 (5), 1042-1055, 2014 | 162 | 2014 |
| Tau local structure shields an amyloid-forming motif and controls aggregation propensity D Chen, KW Drombosky, Z Hou, L Sari, OM Kashmer, BD Ryder, ... Nature communications 10 (1), 2493, 2019 | 146 | 2019 |
| The chaperonin TRiC/CCT associates with prefoldin through a conserved electrostatic interface essential for cellular proteostasis D Gestaut, SH Roh, B Ma, G Pintilie, LA Joachimiak, A Leitner, ... Cell 177 (3), 751-765. e15, 2019 | 129 | 2019 |
| A gradient of ATP affinities generates an asymmetric power stroke driving the chaperonin TRIC/CCT folding cycle S Reissmann, LA Joachimiak, B Chen, AS Meyer, A Nguyen, J Frydman Cell reports 2 (4), 866-877, 2012 | 117 | 2012 |
| Tau strains shape disease J Vaquer-Alicea, MI Diamond, LA Joachimiak Acta neuropathologica 142 (1), 57-71, 2021 | 111 | 2021 |
| xTract: software for characterizing conformational changes of protein complexes by quantitative cross-linking mass spectrometry T Walzthoeni, LA Joachimiak, G Rosenberger, HL Röst, L Malmström, ... Nature methods 12 (12), 1185-1190, 2015 | 107 | 2015 |
| The ATP-powered gymnastics of TRiC/CCT: an asymmetric protein folding machine with a symmetric origin story D Gestaut, A Limatola, L Joachimiak, J Frydman Current opinion in structural biology 55, 50-58, 2019 | 84 | 2019 |
| Exogenous delivery of chaperonin subunit fragment ApiCCT1 modulates mutant Huntingtin cellular phenotypes EM Sontag, LA Joachimiak, Z Tan, A Tomlinson, DE Housman, CG Glabe, ... Proceedings of the National Academy of Sciences 110 (8), 3077-3082, 2013 | 84 | 2013 |
| Structure and dynamics of the huntingtin exon-1 N-terminus: a solution NMR perspective M Baias, PES Smith, K Shen, LA Joachimiak, S Zerko, W Kozminski, ... Journal of the American Chemical Society 139 (3), 1168-1176, 2017 | 65 | 2017 |
| Cryo-EM structure of a group II chaperonin in the prehydrolysis ATP-bound state leading to lid closure J Zhang, B Ma, F DiMaio, NR Douglas, LA Joachimiak, D Baker, ... Structure 19 (5), 633-639, 2011 | 63 | 2011 |
| Experimental and computational analyses of the energetic basis for dual recognition of immunity proteins by colicin endonucleases AH Keeble, LA Joachimiak, MJ Maté, N Meenan, N Kirkpatrick, D Baker, ... Journal of molecular biology 379 (4), 745-759, 2008 | 48 | 2008 |
| DnaJC7 binds natively folded structural elements in tau to inhibit amyloid formation Z Hou, PM Wydorski, VA Perez, A Mendoza-Oliva, BD Ryder, H Mirbaha, ... Nature communications 12 (1), 5338, 2021 | 32 | 2021 |
| Dual domain recognition determines SARS-CoV-2 PLpro selectivity for human ISG15 and K48-linked di-ubiquitin PM Wydorski, J Osipiuk, BT Lanham, C Tesar, M Endres, E Engle, ... Nature communications 14 (1), 2366, 2023 | 30 | 2023 |
Marc I DiamondCenter for Alzheimer's and Neurodegenerative Diseases, University of Texas Southwestern MedicalVerified email at utsouthwestern.edu
