| SIP1, a novel zinc finger/homeodomain repressor, interacts with Smad proteins and binds to 5′-CACCT sequences in candidate target genes K Verschueren, JE Remacle, C Collart, H Kraft, BS Baker, P Tylzanowski, ... Journal of Biological Chemistry 274 (29), 20489-20498, 1999 | 584 | 1999 |
| Activation of NF-κB by Akt upregulates Snail expression and induces epithelium mesenchyme transition S Julien, I Puig, E Caretti, J Bonaventure, L Nelles, F Van Roy, ... Oncogene 26 (53), 7445-7456, 2007 | 555 | 2007 |
| Mice lacking Zfhx1b, the gene that codes for Smad-interacting protein-1, reveal a role for multiple neural crest cell defects in the etiology of Hirschsprung disease–mental … T Van de Putte, M Maruhashi, A Francis, L Nelles, H Kondoh, ... The American Journal of Human Genetics 72 (2), 465-470, 2003 | 338 | 2003 |
| Primary structure of human alpha 2-antiplasmin, a serine protease inhibitor (serpin). WE Holmes, L Nelles, HR Lijnen, D Collen Journal of Biological Chemistry 262 (4), 1659-1664, 1987 | 242 | 1987 |
| Preclinical characterization of GLPG0634, a selective inhibitor of JAK1, for the treatment of inflammatory diseases L Van Rompaey, R Galien, EM van der Aar, P Clement-Lacroix, L Nelles, ... The Journal of Immunology 191 (7), 3568-3577, 2013 | 212 | 2013 |
| Nucleotide sequence of a crustacean 18S ribosomal RNA gene and secondary structure of eukaryotic small subunit ribosoraal RNAs L Nelles, BL Fang, G Volckaert, A Vandenberghe, RD Wachter Nucleic Acids Research 12 (23), 8749-8768, 1984 | 160 | 1984 |
| Characterization of recombinant human single chain urokinase-type plasminogen activator mutants produced by site-specific mutagenesis of lysine 158. L Nelles, HR Lijnen, D Collen, WE Holmes Journal of Biological Chemistry 262 (12), 5682-5689, 1987 | 143 | 1987 |
| Plasminogen activation with single-chain urokinase-type plasminogen activator (scu-PA). Studies with active site mutagenized plasminogen (Ser740----Ala) and plasmin-resistant … HR Lijnen, B Van Hoef, L Nelles, D Collen Journal of Biological Chemistry 265 (9), 5232-5236, 1990 | 141 | 1990 |
| Interaction of AP-1-, AP-2-, and Sp1-like proteins with two distinct sites in the upstream regulatory region of the plasminogen activator inhibitor-1 gene mediates the phorbol … KA Descheemaeker, S Wyns, L Nelles, J Auwerx, T Ny, D Collen Journal of Biological Chemistry 267 (21), 15086-15091, 1992 | 137 | 1992 |
| Characterization of a fusion protein consisting of amino acids 1 to 263 of tissue-type plasminogen activator and amino acids 144 to 411 of urokinase-type plasminogen activator. L Nelles, HR Lijnen, D Collen, WE Holmes Journal of Biological Chemistry 262 (22), 10855-10862, 1987 | 135 | 1987 |
| Molecular and cellular modulation of fibrinolysis K Kolev, R Machovich Thrombosis and haemostasis 89 (04), 610-621, 2003 | 126 | 2003 |
| Triazolopyridines as selective JAK1 inhibitors: from hit identification to GLPG0634 CJ Menet, SR Fletcher, G Van Lommen, R Geney, J Blanc, K Smits, ... Journal of Medicinal Chemistry 57 (22), 9323-9342, 2014 | 120 | 2014 |
| Interaction between Smad-interacting protein-1 and the corepressor C-terminal binding protein is dispensable for transcriptional repression of E-cadherin LA van Grunsven, C Michiels, T Van de Putte, L Nelles, G Wuytens, ... Journal of Biological Chemistry 278 (28), 26135-26145, 2003 | 120 | 2003 |
| Generation of the floxed allele of the SIP1 (Smad-interacting protein 1) gene for Cre-mediated conditional knockout in the mouse Y Higashi, M Maruhashi, L Nelles, T Van de Putte, K Verschueren, ... Genesis: The Journal of Genetics and Development 32 (2), 82-4, 2002 | 113 | 2002 |
| Purification and characterization of natural and recombinant human plasminogen activator inhibitor‐1 (PAI‐1) MC Alessi, PJ Declerck, M De Mol, L Nelles, D Collen European journal of biochemistry 175 (3), 531-540, 1988 | 104 | 1988 |
| Neural crest-specific removal of Zfhx1b in mouse leads to a wide range of neurocristopathies reminiscent of Mowat–Wilson syndrome T Van de Putte, A Francis, L Nelles, LA van Grunsven, D Huylebroeck Human molecular genetics 16 (12), 1423-1436, 2007 | 101 | 2007 |
| Discovery and optimization of an azetidine chemical series as a free fatty acid receptor 2 (FFA2) antagonist: from hit to clinic M Pizzonero, S Dupont, M Babel, S Beaumont, N Bienvenu, R Blanqué, ... Journal of medicinal chemistry 57 (23), 10044-10057, 2014 | 94 | 2014 |
| Biochemical and thrombolytic properties of a low molecular weight form (comprising Leu144 through Leu411) of recombinant single-chain urokinase-type plasminogen activator. HR Lijnen, L Nelles, WE Holmes, D Collen Journal of Biological Chemistry 263 (12), 5594-5598, 1988 | 88 | 1988 |
| The C-terminal domain of Mad-like signal transducers is sufficient for biological activity in the Xenopus embryo and transcriptional activation G Meersseman, K Verschueren, L Nelles, C Blumenstock, H Kraft, ... Mechanisms of development 61 (1-2), 127-140, 1997 | 81 | 1997 |
| Identification of eight novel single-nucleotide polymorphisms at human tissue-type plasminogen activator (t-PA) locus: association with vascular t-PA release in vivo P Ladenvall, U Wall, S Jern, C Jern Thrombosis and haemostasis 84 (08), 150-155, 2000 | 80 | 2000 |
