John C. O'Leary III, PhD
John C. O'Leary III, PhD
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Chemical manipulation of hsp70 ATPase activity regulates tau stability
UK Jinwal, Y Miyata, J Koren, JR Jones, JH Trotter, L Chang, J O'Leary, ...
Journal of neuroscience 29 (39), 12079-12088, 2009
Accelerated neurodegeneration through chaperone-mediated oligomerization of tau
LJ Blair, BA Nordhues, SE Hill, KM Scaglione, JC O’Leary, SN Fontaine, ...
The Journal of clinical investigation 123 (10), 4158-4169, 2013
Tau accumulation activates the unfolded protein response by impairing endoplasmic reticulum-associated degradation
JF Abisambra, UK Jinwal, LJ Blair, JC O'Leary, Q Li, S Brady, L Wang, ...
Journal of Neuroscience 33 (22), 9498-9507, 2013
The Hsp90 cochaperone, FKBP51, increases Tau stability and polymerizes microtubules
UK Jinwal, J Koren III, SI Borysov, AB Schmid, JF Abisambra, LJ Blair, ...
The Journal of Neuroscience 30 (2), 591-599, 2010
Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden
JC O'Leary, Q Li, P Marinec, LJ Blair, EE Congdon, AG Johnson, ...
Molecular neurodegeneration 5 (1), 1-11, 2010
Imbalance of Hsp70 family variants fosters tau accumulation
UK Jinwal, E Akoury, JF Abisambra, JC O'Leary III, AD Thompson, LJ Blair, ...
The FASEB Journal 27 (4), 1450-1459, 2013
A new anti-depressive strategy for the elderly: ablation of FKBP5/FKBP51
JC O'Leary III, S Dharia, LJ Blair, S Brady, AG Johnson, M Peters, ...
PloS one 6 (9), e24840, 2011
Phosphorylation dynamics regulate Hsp27-mediated rescue of neuronal plasticity deficits in tau transgenic mice
JF Abisambra, LJ Blair, SE Hill, JR Jones, C Kraft, J Rogers, J Koren, ...
Journal of Neuroscience 30 (46), 15374-15382, 2010
Facilitating Akt clearance via manipulation of Hsp70 activity and levels
J Koren III, UK Jinwal, Y Jin, J O’Leary, JR Jones, AG Johnson, LJ Blair, ...
Journal of biological chemistry 285 (4), 2498-2505, 2010
Hsc70 rapidly engages tau after microtubule destabilization
UK Jinwal, JC O'Leary III, SI Borysov, JR Jones, Q Li, J Koren III, ...
Journal of biological chemistry 285 (22), 16798-16805, 2010
Age-associated epigenetic upregulation of the FKBP5 gene selectively impairs stress resiliency
JJ Sabbagh, JC O'Leary III, LJ Blair, T Klengel, BA Nordhues, ...
PloS one 9 (9), e107241, 2014
Glucose-regulated protein 94 triage of mutant myocilin through endoplasmic reticulum-associated degradation subverts a more efficient autophagic clearance mechanism
A Suntharalingam, JF Abisambra, JC O'Leary III, J Koren III, B Zhang, ...
Journal of Biological Chemistry 287 (48), 40661-40669, 2012
Cdc37/Hsp90 protein complex disruption triggers an autophagic clearance cascade for TDP-43 protein
UK Jinwal, JF Abisambra, J Zhang, S Dharia, JC O'Leary, T Patel, ...
Journal of Biological Chemistry 287 (29), 24814-24820, 2012
The Hsp90 kinase co-chaperone Cdc37 regulates tau stability and phosphorylation dynamics
UK Jinwal, JH Trotter, JF Abisambra, J Koren III, LY Lawson, GD Vestal, ...
Journal of Biological Chemistry 286 (19), 16976-16983, 2011
The Diarylheptanoid (+)-aR,11S-Myricanol and Two Flavones from Bayberry (Myrica cerifera) Destabilize the Microtubule-Associated Protein Tau
JR Jones, MD Lebar, UK Jinwal, JF Abisambra, J Koren III, L Blair, ...
Journal of natural products 74 (1), 38-44, 2011
Hsp70 ATPase modulators as therapeutics for Alzheimer’s and other neurodegenerative diseases
UK Jinwal, J Koren III, JC O’Leary III, JR Jones, JF Abisambra, CA Dickey
Molecular and cellular pharmacology 2 (2), 43, 2010
Rhodacyanine derivative selectively targets cancer cells and overcomes tamoxifen resistance
J Koren III, Y Miyata, J Kiray, JC O'Leary III, L Nguyen, J Guo, LJ Blair, X Li, ...
PloS one 7 (4), e35566, 2012
The role of FKBP5 in mood disorders: action of FKBP5 on steroid hormone receptors leads to questions about its evolutionary importance
JC O’Leary III, B Zhang, J Koren III, L Blair, C A Dickey
CNS & Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS …, 2013
Neuronal life span versus health span: principles of natural selection at work in the degenerating brain
JC O’Leary, J Koren, CA Dickey
Journal of Molecular Neuroscience 45 (3), 467-472, 2011
Grp94 triage of mutant myocilin through ERAD subverts a more efficient autophagic clearance mechanism
A Suntharalingam, JF Abisambra, JC O'Leary, J Koren, B Zhang, MK Joe, ...
Journal of Biological Chemistry, jbc. M112. 384800, 2012
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