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Chafiq Hamdouchi
Chafiq Hamdouchi
Senior Research Professor of Pathology & Laboratory Medicine at IU School of Medicine
Geverifieerd e-mailadres voor lilly.com - Homepage
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2-Amino-3-substituted-6-[(E)-1-phenyl-2-(N-methylcarbamoyl)vinyl]imidazo[1,2-a]pyridines as a Novel Class of Inhibitors of Human Rhinovirus:  Stereospecific …
C Hamdouchi, J de Blas, M del Prado, J Gruber, BA Heinz, L Vance
Journal of medicinal chemistry 42 (1), 50-59, 1999
3301999
3-(4-Chloro-2-morpholin-4-yl-thiazol-5-yl)-8-(1-ethylpropyl)-2, 6-dimethyl-imidazo [1, 2-b] pyridazine: a novel brain-penetrant, orally available corticotropin-releasing factor …
DR Gehlert, A Cippitelli, A Thorsell, AD Lê, PA Hipskind, C Hamdouchi, ...
Journal of Neuroscience 27 (10), 2718-2726, 2007
2652007
Delayed functional expression of neuronal chemokine receptors following focal nerve demyelination in the rat: a mechanism for the development of chronic sensitization of …
S Bhangoo, D Ren, RJ Miller, KJ Henry, J Lineswala, C Hamdouchi, B Li, ...
Molecular pain 3, 1744-8069-3-38, 2007
2022007
Structure-based design of a new class of highly selective aminoimidazo[1,2-a]pyridine-based inhibitors of cyclin dependent kinases
C Hamdouchi, B Zhong, J Mendoza, E Collins, C Jaramillo, JE De Diego, ...
Bioorganic & medicinal chemistry letters 15 (7), 1943-1947, 2005
1072005
Stress-related neuropeptides and alcoholism: CRH, NPY, and beyond
R Ciccocioppo, DR Gehlert, A Ryabinin, S Kaur, A Cippitelli, A Thorsell, ...
Alcohol 43 (7), 491-498, 2009
852009
On the reaction of chiral sulfinimines with sulfur ylides: a novel route to the asymmetric aziridination
JLG Ruano, I Fernández, C Hamdouchi
Tetrahedron letters 36 (2), 295-298, 1995
801995
A new approach to the synthesis of 2-aminoimidazo[1,2-a]pyridine derivatives through microwave-assisted N-alkylation of 2-halopyridines
JA Vega, JJ Vaquero, J Alvarez-Builla, J Ezquerra, C Hamdouchi
Tetrahedron 55 (8), 2317-2326, 1999
791999
Structural basis for GPR40 allosteric agonism and incretin stimulation
JD Ho, B Chau, L Rodgers, F Lu, KL Wilbur, KA Otto, Y Chen, M Song, ...
Nature Communications 9 (1), 1645, 2018
682018
Imidazo[1,2-b]pyridazines, Novel Nucleus with Potent and Broad Spectrum Activity against Human Picornaviruses:  Design, Synthesis, and Biological Evaluation
C Hamdouchi, C Sanchez-Martinez, J Gruber, M Del Prado, J Lopez, ...
Journal of medicinal chemistry 46 (20), 4333-4341, 2003
652003
The discovery, preclinical, and early clinical development of potent and selective GPR40 agonists for the treatment of type 2 diabetes mellitus (LY2881835, LY2922083, and …
C Hamdouchi, SD Kahl, A Patel Lewis, GR Cardona, RW Zink, K Chen, ...
Journal of Medicinal Chemistry 59 (24), 10891-10916, 2016
562016
Aminoimidazo [1, 2-a] pyridines as a new structural class of cyclin-dependent kinase inhibitors. Part 1: Design, synthesis, and biological evaluation
C Jaramillo, JE de Diego, C Hamdouchi, E Collins, H Keyser, ...
Bioorganic & medicinal chemistry letters 14 (24), 6095-6099, 2004
532004
Short synthesis and anti-rhinoviral activity of imidazo [1, 2-a] pyridines: the effect of acyl groups at 3-position
C Hamdouchi, J Ezquerra, JA Vega, JJ Vaquero, J Alvarez-Builla, ...
Bioorganic & medicinal chemistry letters 9 (10), 1391-1394, 1999
501999
Surface nature of Grignard reagent formation. Chiral 1-methylspiro [2.5] octylmagnesium bromide
C Hamdouchi, M Topolski, V Goedken, HM Walborsky
The Journal of Organic Chemistry 58 (11), 3148-3155, 1993
491993
The discovery of a new structural class of cyclin-dependent kinase inhibitors, aminoimidazo[1,2-a]pyridines
C Hamdouchi, H Keyser, E Collins, C Jaramillo, JE De Diego, ...
Molecular cancer therapeutics 3 (1), 1-9, 2004
482004
Chemoselective arylsulfenylation of 2-aminoimidazol [1, 2-a] pyridines by phenyliodine (III) bis (trifluoroacetate)(PIFA)
C Hamdouchi, C Sanchez, J Ezquerra
Synthesis 1998 (06), 867-872, 1998
441998
(S, S)-bis-p-tolylsulfinylmethane and carbonyl compounds: reactivity and asymmetric induction
G Solladié, F Colobert, P Ruiz, C Hamdouchi, MC Carreno, L José, ...
Tetrahedron letters 32 (30), 3695-3698, 1991
421991
Imidazopyridazine compounds
HJ Barbosa, EA Collins, C Hamdouchi, EJ Hembre, PA Hipskind, ...
US Patent 7,612,067, 2009
402009
A novel application of the Ullmann coupling reaction for the alkylsulfenylation of 2-amino-imidazo[1,2-a]pyridine
C Hamdouchi, J de Blas, J Ezquerra
Tetrahedron 55 (2), 541-548, 1999
361999
A new approach to the asymmetric cyclopropanation via a chiral sulfinyl group
C Hamdouchi
Tetrahedron letters 33 (13), 1701-1704, 1992
351992
The nature of electron transfer from metal surfaces to the carbon-halogen bond
HM Walborsky, C Hamdouchi
Journal of the American Chemical Society 115 (14), 6406-6408, 1993
341993
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