|Metamorphic enzyme assembly in polyketide diversification|
L Gu, B Wang, A Kulkarni, TW Geders, RV Grindberg, L Gerwick, ...
Nature 459 (7247), 731-735, 2009
|Monodisperse Hsp16. 3 nonamer exhibits dynamic dissociation and reassociation, with the nonamer dissociation prerequisite for chaperone-like activity|
L Gu, A Abulimiti, W Li, Z Chang
Journal of molecular biology 319 (2), 517-526, 2002
|GNAT-like strategy for polyketide chain initiation|
L Gu, TW Geders, B Wang, WH Gerwick, K Håkansson, JL Smith, ...
Science 318 (5852), 970-974, 2007
|New tricks from ancient algae: natural products biosynthesis in marine cyanobacteria|
AC Jones, L Gu, CM Sorrels, DH Sherman, WH Gerwick
Current opinion in chemical biology 13 (2), 216-223, 2009
|Metabolic coupling of dehydration and decarboxylation in the curacin A pathway: functional identification of a mechanistically diverse enzyme pair|
L Gu, J Jia, H Liu, K Håkansson, WH Gerwick, DH Sherman
Journal of the American Chemical Society 128 (28), 9014-9015, 2006
|Polyketide Decarboxylative Chain Termination Preceded by O-Sulfonation in Curacin A Biosynthesis|
L Gu, B Wang, A Kulkarni, JJ Gehret, KR Lloyd, L Gerwick, WH Gerwick, ...
Journal of the American Chemical Society 131 (44), 16033-16035, 2009
|Conformational switch triggered by α-ketoglutarate in a halogenase of curacin A biosynthesis|
D Khare, B Wang, L Gu, J Razelun, DH Sherman, WH Gerwick, ...
Proceedings of the National Academy of Sciences 107 (32), 14099-14104, 2010
|Improved cell-free RNA and protein synthesis system|
J Li, L Gu, J Aach, GM Church
PLoS One 9 (9), e106232, 2014
|Terminal alkene formation by the thioesterase of curacin A biosynthesis: structure of a decarboxylating thioesterase|
JJ Gehret, L Gu, WH Gerwick, P Wipf, DH Sherman, JL Smith
Journal of Biological Chemistry 286 (16), 14445-14454, 2011
|Multiplex single-molecule interaction profiling of DNA-barcoded proteins|
L Gu, C Li, J Aach, DE Hill, M Vidal, GM Church
Nature 515 (7528), 554-557, 2014
|Phylogenetic and chemical diversity of three chemotypes of bloom-forming Lyngbya species (Cyanobacteria: Oscillatoriales) from reefs of southeastern Florida|
K Sharp, KE Arthur, L Gu, C Ross, G Harrison, SP Gunasekera, T Meickle, ...
Applied and Environmental Microbiology 75 (9), 2879-2888, 2009
|Small heat shock protein Hsp16. 3 modulates its chaperone activity by adjusting the rate of oligomeric dissociation|
X Fu, C Liu, Y Liu, X Feng, L Gu, X Chen, Z Chang
Biochemical and biophysical research communications 310 (2), 412-420, 2003
|Crystal structure of the ECH2 catalytic domain of CurF from Lyngbya majuscula: Insights into a decarboxylase involved in polyketide chain β-branching|
TW Geders, L Gu, JC Mowers, H Liu, WH Gerwick, K Håkansson, ...
Journal of Biological Chemistry 282 (49), 35954-35963, 2007
|Structure and activity of DmmA, a marine haloalkane dehalogenase|
JJ Gehret, L Gu, TW Geders, WC Brown, L Gerwick, WH Gerwick, ...
Protein Science 21 (2), 239-248, 2012
|Tandem acyl carrier proteins in the curacin biosynthetic pathway promote consecutive multienzyme reactions with a synergistic effect|
L Gu, EB Eisman, S Dutta, TM Franzmann, S Walter, WH Gerwick, ...
Angewandte Chemie International Edition 50 (12), 2795-2798, 2011
|Characterization of molecular interactions between ACP and halogenase domains in the curacin A polyketide synthase|
A Busche, D Gottstein, C Hein, N Ripin, I Pader, P Tufar, EB Eisman, L Gu, ...
ACS chemical biology 7 (2), 378-386, 2012
|Mycobacterium tuberculosis Hsp16. 3 nonamers are assembled and re-assembled via trimer and hexamer intermediates|
A Abulimiti, X Fu, L Gu, X Feng, Z Chang
Journal of molecular biology 326 (4), 1013-1023, 2003
|Structural basis for cyclopropanation by a unique enoyl-acyl carrier protein reductase|
D Khare, WA Hale, A Tripathi, L Gu, DH Sherman, WH Gerwick, ...
Structure 23 (12), 2213-2223, 2015
|COMBINES-CID: An efficient method for de novo engineering of highly specific chemically induced protein dimerization systems|
S Kang, K Davidsen, L Gomez-Castillo, H Jiang, X Fu, Z Li, Y Liang, ...
Journal of the American Chemical Society 141 (28), 10948-10952, 2019
|Method for enzymatic production of decarboxylated polyketides and fatty acids|
DH Sherman, JL Smith, L Gu, J Gehret
US Patent 8,765,431, 2014