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Tom Taghon
Tom Taghon
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A cell atlas of human thymic development defines T cell repertoire formation
JE Park, RA Botting, C Domínguez Conde, DM Popescu, M Lavaert, ...
Science 367 (6480), eaay3224, 2020
4882020
Stellate cells, hepatocytes, and endothelial cells imprint the Kupffer cell identity on monocytes colonizing the liver macrophage niche
J Bonnardel, W T’Jonck, D Gaublomme, R Browaeys, CL Scott, L Martens, ...
Immunity 51 (4), 638-654. e9, 2019
4332019
A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia
A Klinakis, C Lobry, O Abdel-Wahab, P Oh, H Haeno, S Buonamici, ...
Nature 473 (7346), 230-233, 2011
4262011
Developmental and molecular characterization of emerging β-and γδ-selected pre-T cells in the adult mouse thymus
T Taghon, MA Yui, R Pant, RA Diamond, EV Rothenberg
Immunity 24 (1), 53-64, 2006
3982006
Molecular genetics of T cell development
EV Rothenberg, T Taghon
Annu. Rev. Immunol. 23, 601-649, 2005
3582005
PHF6 mutations in T-cell acute lymphoblastic leukemia
P Van Vlierberghe, T Palomero, H Khiabanian, J Van der Meulen, ...
Nature genetics 42 (4), 338-342, 2010
3352010
A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL)
KJ Mavrakis, J Van Der Meulen, AL Wolfe, X Liu, E Mets, T Taghon, ...
Nature genetics 43 (7), 673-678, 2011
3282011
Generation of T cells from human embryonic stem cell-derived hematopoietic zones
F Timmermans, I Velghe, L Vanwalleghem, M De Smedt, ...
The Journal of Immunology 182 (11), 6879-6888, 2009
2492009
ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia
S Peirs, F Matthijssens, S Goossens, I Van de Walle, K Ruggero, ...
Blood, The Journal of the American Society of Hematology 124 (25), 3738-3747, 2014
2372014
Mast cell lineage diversion of T lineage precursors by the essential T cell transcription factor GATA-3
T Taghon, MA Yui, EV Rothenberg
Nature immunology 8 (8), 845-855, 2007
2362007
Delayed, asynchronous, and reversible T-lineage specification induced by Notch/Delta signaling
TN Taghon, ES David, JC Zúñiga-Pflücker, EV Rothenberg
Genes & development 19 (8), 965-978, 2005
2152005
The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia
J Van der Meulen, V Sanghvi, K Mavrakis, K Durinck, F Fang, ...
Blood, The Journal of the American Society of Hematology 125 (1), 13-21, 2015
2042015
Quantification of reverse transcriptase activity by real-time PCR as a fast and accurate method for titration of HIV, lenti-and retroviral vectors
J Vermeire, E Naessens, H Vanderstraeten, A Landi, V Iannucci, ...
PloS one 7 (12), e50859, 2012
2012012
An early decrease in Notch activation is required for human TCR-αβ lineage differentiation at the expense of TCR-γδ T cells
I Van de Walle, G De Smet, M De Smedt, B Vandekerckhove, G Leclercq, ...
Blood, The Journal of the American Society of Hematology 113 (13), 2988-2998, 2009
1462009
Active form of Notch imposes T cell fate in human progenitor cells
M De Smedt, K Reynvoet, T Kerre, T Taghon, B Verhasselt, ...
The Journal of Immunology 169 (6), 3021-3029, 2002
1452002
Notch/Delta signaling constrains reengineering of pro-T cells by PU. 1
CB Franco, DD Scripture-Adams, I Proekt, T Taghon, AH Weiss, MA Yui, ...
Proceedings of the National Academy of Sciences 103 (32), 11993-11998, 2006
1322006
Specific Notch receptor–ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength
I Van de Walle, E Waegemans, J De Medts, G De Smet, M De Smedt, ...
Journal of Experimental Medicine 210 (4), 683-697, 2013
1262013
Specific Notch receptor–ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength
I Van de Walle, E Waegemans, J De Medts, G De Smet, M De Smedt, ...
Journal of Experimental Medicine 210 (4), 683-697, 2013
1262013
Molecular dissection of prethymic progenitor entry into the T lymphocyte developmental pathway
CC Tydell, ES David-Fung, JE Moore, L Rowen, T Taghon, ...
The Journal of Immunology 179 (1), 421-438, 2007
1242007
MicroRNA-193b-3p acts as a tumor suppressor by targeting the MYB oncogene in T-cell acute lymphoblastic leukemia
E Mets, J Van der Meulen, G Van Peer, M Boice, P Mestdagh, ...
Leukemia 29 (4), 798-806, 2015
1202015
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