Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells CC Kloss, M Condomines, M Cartellieri, M Bachmann, M Sadelain Nature biotechnology, 2012 | 970 | 2012 |
Structural design of engineered costimulation determines tumor rejection kinetics and persistence of CAR T cells Z Zhao, M Condomines, SJC van der Stegen, F Perna, CC Kloss, ... Cancer cell 28 (4), 415-428, 2015 | 791 | 2015 |
Dominant Negative TGFβ Receptor Enhances PSMA Targeted Human CAR T Cell Proliferation and Augments Tumor Eradication in Prostate Cancer CC Kloss, J Lee, A Zhang, F Chen, JJ Melenhorst, SF Lacey, MV Maus, ... Molecular Therapy, 2018 | 498* | 2018 |
Generation of tumor-targeted human T lymphocytes from induced pluripotent stem cells for cancer therapy M Themeli, CC Kloss, G Ciriello, VD Fedorov, F Perna, M Gonen, ... Nature biotechnology, 2013 | 493 | 2013 |
Rational development and characterization of humanized anti–EGFR variant III chimeric antigen receptor T cells for glioblastoma LA Johnson, J Scholler, T Ohkuri, A Kosaka, PR Patel, SE McGettigan, ... Science translational medicine 7 (275), 275ra22-275ra22, 2015 | 491 | 2015 |
CD19 CAR-Targeted T Cells Induce Long-Term Remission and B Cell Aplasia in an Immunocompetent Mouse Model of B Cell Acute Lymphoblastic Leukemia ML Davila, CC Kloss, G Gunset, M Sadelain PloS one 8 (4), e61338, 2013 | 234 | 2013 |
Human ESC-derived hemogenic endothelial cells undergo distinct waves of endothelial to hematopoietic transition S Rafii, CC Kloss, JM Butler, M Ginsberg, E Gars, R Lis, Q Zhan, ... Blood 121 (5), 770-780, 2013 | 124 | 2013 |
Production of BMP4 by endothelial cells is crucial for endogenous thymic regeneration T Wertheimer, E Velardi, J Tsai, K Cooper, S Xiao, CC Kloss, KJ Ottmüller, ... Science immunology 3 (19), 2018 | 121 | 2018 |
Driving cars to the clinic for solid tumors M Castellarin, K Watanabe, CH June, CC Kloss, AD Posey Gene therapy 25 (3), 165-175, 2018 | 86 | 2018 |
Activation of the vascular niche supports leukemic progression and resistance to chemotherapy MG Poulos, EJ Gars, MC Gutkin, CC Kloss, M Ginsberg, JM Scandura, ... Experimental hematology 42 (11), 976-986. e3, 2014 | 64 | 2014 |
A large-scale study of differential gene expression in monocyte-derived macrophages infected with several strains of Mycobacterium avium subspecies paratuberculosis E Kabara, CC Kloss, M Wilson, RJ Tempelman, S Sreevatsan, ... Briefings in Functional Genomics 9 (3), 220-237, 2010 | 63 | 2010 |
Chronic activation of endothelial MAPK disrupts hematopoiesis via NFKB dependent inflammatory stress reversible by SCGF P Ramalingam, MG Poulos, E Lazzari, MC Gutkin, D Lopez, CC Kloss, ... Nature communications 11 (1), 1-20, 2020 | 54 | 2020 |
Novel Approaches to Enhance the Specificity and Safety of Engineered T Cells VD Fedorov, M Sadelain, CC Kloss The Cancer Journal 20 (2), 160-165, 2014 | 51 | 2014 |
Double or nothing on cancer immunotherapy K Hanada, NP Restifo Nature biotechnology 31 (1), 33-34, 2013 | 22 | 2013 |
Lentiviral Transduction and Clonal Selection of hESCs with Endothelial‐Specific Transgenic Reporters D James, Q Zhan, C Kloss, N Zaninovic, Z Rosenwaks, S Rafii Current Protocols in Stem Cell Biology, 1F. 12.1-1F. 12.14, 2011 | 11 | 2011 |
Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells CK CHRISTOPHER, M CONDOMINES, M CARTELLIERI, M BACHMANN, ... NATURE BIOTECHNOLOGY 31 (1), 2012-12, 2012 | 10 | 2012 |
Production of BMP4 By Endothelial Cells Is Crucial for Endogenous Thymic Regeneration T Wertheimer, E Velardi, C Brede, S Xiao, CC Kloss, A Beilhack, ... Blood 126 (23), 637, 2015 | 2 | 2015 |
CD19-Targeted Donor T Cells Exert Potent Graft Versus Lymphoma Activity and Attenuated Gvhd A Ghosh, ML Davila, LF Young, C Kloss, G Gunset, OM Smith, ML West, ... BLOOD 120 (21), 2012 | 2 | 2012 |
Validation of a humanized anti-EGFR variant III chimeric antigen receptor for a Phase I trial of CART-EGFRvIII in glioblastoma J Brogdon, A Loew, P Thekkat, N Idamakanti, B Engels, R Singh, T Ezell, ... Science Translational Medicine, 2015 | 1 | 2015 |
4-1BBL costimulation enables CD4 T cells expressing a CD28/zeta chimeric antigen receptor to eliminate aggressive leukemia.(P4338) M Condomines, Z Zhao, X Wang, C Kloss, M Davila, M Sadelain The Journal of Immunology 190, 177.2, 2013 | 1 | 2013 |