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Diane Hanger
Diane Hanger
Emeritus Professor of Neuroscience, King's College London
Geverifieerd e-mailadres voor kcl.ac.uk - Homepage
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Tau phosphorylation: the therapeutic challenge for neurodegenerative disease
DP Hanger, BH Anderton, W Noble
Trends in molecular medicine 15 (3), 112-119, 2009
11002009
Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: generation of paired helical filament epitopes and neuronal localisation of the kinase
DP Hanger, K Hughes, JR Woodgett, JP Brion, BH Anderton
Neuroscience letters 147 (1), 58-62, 1992
9321992
Roles of tau protein in health and disease
T Guo, W Noble, DP Hanger
Acta neuropathologica 133, 665-704, 2017
9232017
Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells
S Lovestone, CH Reynolds, D Latimer, DR Davis, BH Anderton, JM Gallo, ...
Current Biology 4 (12), 1077-1086, 1994
6371994
Physiological release of endogenous tau is stimulated by neuronal activity
AM Pooler, EC Phillips, DHW Lau, W Noble, DP Hanger
EMBO reports 14 (4), 389-394, 2013
6242013
Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis
DP Hanger, HL Byers, S Wray, KY Leung, MJ Saxton, A Seereeram, ...
Journal of Biological Chemistry 282 (32), 23645-23654, 2007
5272007
New phosphorylation sites identified in hyperphosphorylated tau (paired helical filament‐tau) from Alzheimer's disease brain using nanoelectrospray mass spectrometry
DP Hanger, JC Betts, TLF Loviny, WP Blackstock, BH Anderton
Journal of neurochemistry 71 (6), 2465-2476, 1998
4761998
The importance of tau phosphorylation for neurodegenerative diseases
W Noble, DP Hanger, CC Miller, S Lovestone
Frontiers in neurology 4, 54249, 2013
4502013
Astrocytes are important mediators of Aβ-induced neurotoxicity and tau phosphorylation in primary culture
CJ Garwood, AM Pooler, J Atherton, DP Hanger, W Noble
Cell death & disease 2 (6), e167-e167, 2011
3822011
The ER-mitochondria tethering complex VAPB-PTPIP51 regulates autophagy
P Gomez-Suaga, S Paillusson, R Stoica, W Noble, DP Hanger, CCJ Miller
Current Biology 27 (3), 371-385, 2017
3472017
α-Synuclein binds to the ER–mitochondria tethering protein VAPB to disrupt Ca2+ homeostasis and mitochondrial ATP production
S Paillusson, P Gomez-Suaga, R Stoica, D Little, P Gissen, MJ Devine, ...
Acta neuropathologica 134, 129-149, 2017
3222017
Phosphorylation regulates tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase Cγ1, Grb2, and Src family kinases
CH Reynolds, CJ Garwood, S Wray, C Price, S Kellie, T Perera, ...
Journal of Biological Chemistry 283 (26), 18177-18186, 2008
2902008
ALS/FTD‐associated FUS activates GSK‐3β to disrupt the VAPB–PTPIP 51 interaction and ER–mitochondria associations
R Stoica, S Paillusson, P Gomez‐Suaga, JC Mitchell, DHW Lau, EH Gray, ...
EMBO reports 17 (9), 1326-1342, 2016
2482016
Pathological inclusion bodies in tauopathies contain distinct complements of tau with three or four microtubule‐binding repeat domains as demonstrated by new specific …
R De Silva, T Lashley, G Gibb, D Hanger, A Hope, A Reid, ...
Neuropathology and applied neurobiology 29 (3), 288-302, 2003
2432003
A role for tau at the synapse in Alzheimer's disease pathogenesis
AM Pooler, W Noble, DP Hanger
Neuropharmacology 76, 1-8, 2014
2312014
Tyrosine 394 is phosphorylated in Alzheimer's paired helical filament tau and in fetal tau with c-Abl as the candidate tyrosine kinase
P Derkinderen, TME Scales, DP Hanger, KY Leung, HL Byers, MA Ward, ...
Journal of Neuroscience 25 (28), 6584-6593, 2005
2292005
Induction of neuronal death by α‐synuclein
AR Saha, NN Ninkina, DP Hanger, BH Anderton, AM Davies, ...
European Journal of Neuroscience 12 (8), 3073-3077, 2000
2192000
Parkinson's disease α-synuclein mutations exhibit defective axonal transport in cultured neurons
AR Saha, J Hill, MA Utton, AA Asuni, S Ackerley, AJ Grierson, CC Miller, ...
Journal of cell science 117 (7), 1017-1024, 2004
2112004
Tau phosphorylation affects its axonal transport and degradation
T Rodríguez-Martín, I Cuchillo-Ibáñez, W Noble, F Nyenya, BH Anderton, ...
Neurobiology of aging 34 (9), 2146-2157, 2013
2032013
Phosphorylation of tau regulates its axonal transport by controlling its binding to kinesin
I Cuchillo‐Ibanez, A Seereeram, HL Byers, KY Leung, MA Ward, ...
The FASEB Journal 22 (9), 3186-3195, 2008
2032008
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