| Review of Ginkgo biloba-induced toxicity, from experimental studies to human case reports N Mei, X Guo, Z Ren, D Kobayashi, K Wada, L Guo Journal of Environmental Science and Health, Part C 35 (1), 1-28, 2017 | 148 | 2017 |
| Bidirectional homeostatic regulation of a depression-related brain state by gamma-aminobutyric acidergic deficits and ketamine treatment Z Ren, H Pribiag, SJ Jefferson, M Shorey, T Fuchs, D Stellwagen, ... Biological psychiatry 80 (6), 457-468, 2016 | 116 | 2016 |
| smad2 and smad3 are required for mesendoderm induction by transforming growth factor-β/nodal signals in zebrafish S Jia, Z Ren, X Li, Y Zheng, A Meng Journal of Biological Chemistry 283 (4), 2418-2426, 2008 | 71 | 2008 |
| MicroRNA hsa-miR-370-3p suppresses the expression and induction of CYP2D6 by facilitating mRNA degradation L Zeng, Y Chen, Y Wang, LR Yu, B Knox, J Chen, T Shi, S Chen, Z Ren, ... Biochemical pharmacology 140, 139-149, 2017 | 63 | 2017 |
| The expression, induction and pharmacological activity of CYP1A2 are post-transcriptionally regulated by microRNA hsa-miR-132-5p Y Chen, L Zeng, Y Wang, WH Tolleson, B Knox, S Chen, Z Ren, L Guo, ... Biochemical pharmacology 145, 178-191, 2017 | 56 | 2017 |
| Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans D Yu, L Wu, P Gill, WH Tolleson, S Chen, J Sun, B Knox, Y Jin, W Xiao, ... Archives of toxicology 92, 845-858, 2018 | 53 | 2018 |
| MicroRNA hsa-miR-25-3p suppresses the expression and drug induction of CYP2B6 in human hepatocytes Y Jin, D Yu, WH Tolleson, B Knox, Y Wang, S Chen, Z Ren, H Deng, ... Biochemical pharmacology 113, 88-96, 2016 | 49 | 2016 |
| Mitochondrial dysfunction induced by leflunomide and its active metabolite J Xuan, Z Ren, T Qing, L Couch, L Shi, WH Tolleson, L Guo Toxicology 396, 33-45, 2018 | 48 | 2018 |
| ROS generation and JNK activation contribute to 4-methoxy-TEMPO-induced cytotoxicity, autophagy, and DNA damage in HepG2 cells Z Zhang, Z Ren, S Chen, X Guo, F Liu, L Guo, N Mei Archives of toxicology 92, 717-728, 2018 | 48 | 2018 |
| Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells Z Ren, S Chen, T Qing, J Xuan, L Couch, D Yu, B Ning, L Shi, L Guo Toxicology 392, 11-21, 2017 | 48 | 2017 |
| Defects in dendrite and spine maturation and synaptogenesis associated with an anxious-depressive-like phenotype of GABAA receptor-deficient mice Z Ren, N Sahir, S Murakami, BA Luellen, JC Earnheart, R Lal, JY Kim, ... Neuropharmacology 88, 171-179, 2015 | 48 | 2015 |
| Activation of the Nrf2 signaling pathway in usnic acid-induced toxicity in HepG2 cells S Chen, Z Zhang, T Qing, Z Ren, D Yu, L Couch, B Ning, N Mei, L Shi, ... Archives of toxicology 91, 1293-1307, 2017 | 45 | 2017 |
| A systematic evaluation of microRNAs in regulating human hepatic CYP2E1 Y Wang, D Yu, WH Tolleson, LR Yu, B Green, L Zeng, Y Chen, S Chen, ... Biochemical pharmacology 138, 174-184, 2017 | 42 | 2017 |
| The role of CYP 3A4 and 1A1 in amiodarone-induced hepatocellular toxicity Q Wu, B Ning, J Xuan, Z Ren, L Guo, MS Bryant Toxicology letters 253, 55-62, 2016 | 39 | 2016 |
| Endoplasmic reticulum stress induction and ERK1/2 activation contribute to nefazodone-induced toxicity in hepatic cells Z Ren, S Chen, J Zhang, U Doshi, AP Li, L Guo Toxicological Sciences 154 (2), 368-380, 2016 | 28 | 2016 |
| Characterization of cytochrome P450s (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicity S Chen, Q Wu, X Li, D Li, N Mei, B Ning, M Puig, Z Ren, WH Tolleson, ... Journal of Environmental Science and Health, Part C 39 (1), 68-86, 2021 | 24 | 2021 |
| DNA damage‐induced apoptosis and mitogen‐activated protein kinase pathway contribute to the toxicity of dronedarone in hepatic cells S Chen, Z Ren, D Yu, B Ning, L Guo Environmental and molecular mutagenesis 59 (4), 278-289, 2018 | 23 | 2018 |
| The role of hepatic cytochrome P450s in the cytotoxicity of sertraline S Chen, Q Wu, X Li, D Li, M Fan, Z Ren, M Bryant, N Mei, B Ning, L Guo Archives of toxicology 94, 2401-2411, 2020 | 17 | 2020 |
| A mechanism of perhexiline's cytotoxicity in hepatic cells involves endoplasmic reticulum stress and p38 signaling pathway Z Ren, S Chen, S Pak, L Guo Chemico-biological interactions 334, 109353, 2021 | 12 | 2021 |
| Mitochondrial dysfunction and apoptosis underlie the hepatotoxicity of perhexiline Z Ren, S Chen, JE Seo, X Guo, D Li, B Ning, L Guo Toxicology In Vitro 69, 104987, 2020 | 12 | 2020 |
SI CHENNational Center for Toxicological ResearchVerified email at fda.hhs.gov
