Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA A Vries, CTM van Oostrom, FMA Hofhuis, PM Dortant, RJW Berg, ... Nature 377 (6545), 169-173, 1995 | 448 | 1995 |
Targeted point mutations of p53 lead to dominant-negative inhibition of wild-type p53 function A De Vries, ER Flores, B Miranda, HM Hsieh, CTM Van Oostrom, J Sage, ... Proceedings of the National Academy of Sciences 99 (5), 2948-2953, 2002 | 270 | 2002 |
High incidence of protein-truncating TP53 mutations in BRCA1-related breast cancer H Holstege, SA Joosse, CTM van Oostrom, PM Nederlof, A de Vries, ... Cancer research 69 (8), 3625-3633, 2009 | 208 | 2009 |
Activation of the p53-dependent G1 checkpoint response in mouse embryo fibroblasts depends on the specific DNA damage inducer LD Attardi, A de Vries, T Jacks Oncogene 23 (4), 973-980, 2004 | 153 | 2004 |
Defective apoptosis and B‐cell lymphomas in mice with p53 point mutation at Ser 23 D MacPherson, J Kim, T Kim, BK Rhee, CTM van Oostrom, RA DiTullio Jr, ... The EMBO journal 23 (18), 3689-3699, 2004 | 152 | 2004 |
Increased sensitivity to UV radiation in mice with a p53 point mutation at Ser389 W Bruins, E Zwart, LD Attardi, T Iwakuma, EM Hoogervorst, RB Beems, ... Molecular and cellular biology 24 (20), 8884-8894, 2004 | 137 | 2004 |
Spontaneous liver tumors and Benzo [a] pyrene‐induced lymphomas in XPA‐deficient mice A de Vries, CTM van Oostrom, PM Dortant, RB Beems, CF van Kreijl, ... Molecular Carcinogenesis: Published in cooperation with the University of …, 1997 | 95 | 1997 |
Induction of DNA adducts and mutations in spleen, liver and lung of XPA-deficient/lacZ transgenic mice after oral treatment with benzo [a] pyrene: correlation with tumour … A De Vries, ME Dolle, JL Broekhof, JJ Muller, ED Kroese, CF Van Kreijl, ... Carcinogenesis 18 (12), 2327-2332, 1997 | 89 | 1997 |
Mice expressing a mammary gland–specific R270H mutation in the p53 tumor suppressor gene mimic human breast cancer development SWP Wijnhoven, E Zwart, EN Speksnijder, RB Beems, KP Olive, ... Cancer Research 65 (18), 8166-8173, 2005 | 84 | 2005 |
Relative Susceptibilities of XPA Knockout Mice and Their Heterozygous and Wild-Type Littermates to UVB-induced Skin Cancer RJW Berg, A de Vries, H van Steeg, FR de Gruijl Cancer research 57 (4), 581-584, 1997 | 76 | 1997 |
In vivo p53 response and immune reaction underlie highly effective low-dose radiotherapy in follicular lymphoma L Knoops, R Haas, S de Kemp, D Majoor, A Broeks, E Eldering, ... Blood, The Journal of the American Society of Hematology 110 (4), 1116-1122, 2007 | 68 | 2007 |
DNA Repair—Deficient Xpa and Xpa/p53+/-Knock-Out Mice: Nature of the Models H Van Steeg, A De Vries, CTHM Van Oostrom, J Van Benthem, ... Toxicologic pathology 29 (1_suppl), 109-116, 2001 | 63 | 2001 |
Nucleotide excision repair-and p53-deficient mouse models in cancer research EM Hoogervorst, H van Steeg, A de Vries Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 574 (1 …, 2005 | 61 | 2005 |
Mouse models for the p53 R72P polymorphism mimic human phenotypes F Zhu, MET Dollé, TR Berton, RV Kuiper, C Capps, A Espejo, MJ McArthur, ... Cancer research 70 (14), 5851-5859, 2010 | 58 | 2010 |
Dominant-Negative but not Gain-of-Function Effects of a p53.R270H Mutation in Mouse Epithelium Tissue after DNA Damage SWP Wijnhoven, EN Speksnijder, X Liu, E Zwart, CTM vanoostrom, ... Cancer research 67 (10), 4648-4656, 2007 | 58 | 2007 |
Identification of interleukin‐1 beta, but no other inflammatory proteins, as an early onset pre‐eclampsia biomarker in first trimester serum by bead‐based multiplexed immunoassays JE Siljee, EJ Wortelboer, MPH Koster, S Imholz, W Rodenburg, ... Prenatal diagnosis 33 (12), 1183-1188, 2013 | 57 | 2013 |
A bead-based multiplexed immunoassay to evaluate breast cancer biomarkers for early detection in pre-diagnostic serum AWJ Opstal-van Winden, W Rodenburg, JLA Pennings, CTM van Oostrom, ... International journal of molecular sciences 13 (10), 13587-13604, 2012 | 57 | 2012 |
Overlapping gene expression profiles of model compounds provide opportunities for immunotoxicity screening KA Baken, JLA Pennings, MJ Jonker, MM Schaap, A de Vries, ... Toxicology and applied pharmacology 226 (1), 46-59, 2008 | 54 | 2008 |
Lack of p53 Ser389 phosphorylation predisposes mice to develop 2-acetylaminofluorene–induced bladder tumors but not ionizing radiation–induced lymphomas EM Hoogervorst, W Bruins, E Zwart, CTM van Oostrom, ... Cancer research 65 (9), 3610-3616, 2005 | 41 | 2005 |
The absence of Ser389 phosphorylation in p53 affects the basal gene expression level of many p53-dependent genes and alters the biphasic response to UV exposure in mouse … W Bruins, O Bruning, MJ Jonker, E Zwart, TV van der Hoeven, ... Molecular and cellular biology, 2008 | 40 | 2008 |