| Clonal evolution in patients with chronic lymphocytic leukaemia developing resistance to BTK inhibition JA Burger, DA Landau, A Taylor-Weiner, I Bozic, H Zhang, K Sarosiek, ... Nature communications 7 (1), 11589, 2016 | 370 | 2016 |
| Developmental regulation of mitochondrial apoptosis by c-Myc governs age-and tissue-specific sensitivity to cancer therapeutics KA Sarosiek, C Fraser, N Muthalagu, PD Bhola, W Chang, SK McBrayer, ... Cancer cell 31 (1), 142-156, 2017 | 240 | 2017 |
| Exploiting MCL1 Dependency with Combination MEK + MCL1 Inhibitors Leads to Induction of Apoptosis and Tumor Regression in KRAS-Mutant Non–Small Cell … V Nangia, FM Siddiqui, S Caenepeel, D Timonina, SJ Bilton, N Phan, ... Cancer discovery 8 (12), 1598-1613, 2018 | 84 | 2018 |
| Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 severity Z Inde, BA Croker, C Yapp, GN Joshi, J Spetz, C Fraser, X Qin, L Xu, ... Science Advances 7 (34), eabf8609, 2021 | 62 | 2021 |
| BH3 profiling: a functional assay to measure apoptotic priming and dependencies C Fraser, J Ryan, K Sarosiek BCL-2 Family Proteins: Methods and Protocols, 61-76, 2019 | 38 | 2019 |
| Mechanisms of lymphoma clearance induced by high-dose alkylating agents C Lossos, Y Liu, KE Kolb, AL Christie, A Van Scoyk, SM Prakadan, ... Cancer discovery 9 (7), 944-961, 2019 | 36 | 2019 |
| Exploiting MCL1 dependency with combination MEK+ MCL1 inhibitors leads to induction of apoptosis and tumor regression in KRAS-mutant non-small cell lung cancer. Cancer Discov … V Nangia, FM Siddiqui, S Caenepeel, D Timonina, SJ Bilton, N Phan, ... CD-18-0277.[Europe PMC free article][Abstract][CrossRef][Google Scholar], 0 | 15 | |
| Heightened apoptotic priming of vascular cells across tissues and life span predisposes them to cancer therapy–induced toxicities JKE Spetz, MHC Florido, CS Fraser, X Qin, J Choiniere, SJ Yu, R Singh, ... Science Advances 8 (45), eabn6579, 2022 | 8 | 2022 |
| Exploiting endogenous and therapy-induced apoptotic vulnerabilities in immunoglobulin light chain amyloidosis with BH3 mimetics CS Fraser, JKE Spetz, X Qin, A Presser, J Choiniere, C Li, S Yu, F Blevins, ... Nature communications 13 (1), 5789, 2022 | 7 | 2022 |
| A Mesenchymal Tumor Cell State Confers Increased Dependency on the BCL-XL Antiapoptotic Protein in Kidney Cancer T Grubb, S Maganti, JM Krill-Burger, C Fraser, L Stransky, ... Clinical Cancer Research 28 (21), 4689-4701, 2022 | 6 | 2022 |
| Radiotherapy-Induced Neurocognitive Impairment Is Driven by Heightened Apoptotic Priming in Early Life and Prevented by Blocking BAX R Singh, S Yu, M Osman, Z Inde, C Fraser, AH Cleveland, N Almanzar, ... Cancer Research 83 (20), 3442-3461, 2023 | 4 | 2023 |
| Clonal evolution in patients with chronic lymphocytic leukaemia developing resistance to BTK inhibition. Nat Commun. 2016; 7: 11589 JA Burger, DA Landau, A Taylor-Weiner, I Bozic, H Zhang, K Sarosiek, ... The paper describes/confirms that chemotherapy can “select” for prior …, 0 | 4 | |
| Dynamic BH3 profiling reveals novel therapeutic strategies for the treatment of double-hit lymphoma J Crombie, C Lossos, K Sarosiek, AL Christie, C Fraser, S Bhatt, J Deng, ... Blood 130, 2764, 2017 | 3 | 2017 |
| Clonal plasma cells in AL amyloidosis are dependent on pro survival BCL-2 family proteins and sensitive to BH3 mimetics C Fraser, A Presser, V Sanchorawala, S Sarosiek, K Sarosiek bioRxiv, 542159, 2019 | 2 | 2019 |
| AI is a viable alternative to high throughput screening: a 318-target study Scientific Reports 14 (1), 7526, 2024 | 1 | 2024 |
| Apoptosis inducing agent 1 enhances cancer therapy-induced apoptosis by direct interaction with BAX and BAK X Qin, C Fraser, A Presser, JKE Spetz, SJ Yu, GA Bradshaw, M Kalocsay, ... Cancer Research 83 (7_Supplement), 5731-5731, 2023 | 1 | 2023 |
| p53 controls choice between apoptotic and non-apoptotic death following DNA damage ME Honeywell, MS Isidor, NW Harper, RE Fontana, P Cruz-Gordillo, ... bioRxiv, 2023 | 1 | 2023 |
| Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex MC McNamara, AM Hosios, ME Torrence, T Zhao, C Fraser, M Wilkinson, ... Iscience 25 (11), 2022 | 1 | 2022 |
| LKB1 loss rewires JNK-induced apoptotic protein dynamics through NUAKs and sensitizes KRAS-mutant NSCLC to combined KRASG12C + MCL-1 blockade C Li, MU Syed, Y Shen, C Fraser, J Ouyang, J Kreuzer, SE Clark, A Oh, ... bioRxiv, 2022.09. 29.510137, 2022 | 1 | 2022 |
| Clonal Plasma Cells in AL Amyloidosis Are Dependent on Anti-Apoptotic BCL-2 Family Proteins C Fraser, V Sanchorawala, K Sarosiek, S Sarosiek Blood, The Journal of the American Society of Hematology 132 (Supplement 1 …, 2018 | 1 | 2018 |
