Doug Cyr
Doug Cyr
Department of Cell Biology and Physiology, UNC Chapel Hill
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The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation
GC Meacham, C Patterson, W Zhang, JM Younger, DM Cyr
Nature cell biology 3 (1), 100-105, 2001
CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation
J Jiang, CA Ballinger, Y Wu, Q Dai, DM Cyr, J Höhfeld, C Patterson
Journal of Biological Chemistry 276 (46), 42938-42944, 2001
DnaJ-like proteins: molecular chaperones and specific regulators of Hsp70
DM Cyr, T Langer, MG Douglas
Trends in biochemical sciences 19 (4), 176-181, 1994
The J‐protein family: modulating protein assembly, disassembly and translocation
P Walsh, D Bursać, YC Law, D Cyr, T Lithgow
EMBO reports 5 (6), 567-571, 2004
Sequential quality-control checkpoints triage misfolded cystic fibrosis transmembrane conductance regulator
JM Younger, L Chen, HY Ren, MFN Rosser, EL Turnbull, CY Fan, ...
Cell 126 (3), 571-582, 2006
From the cradle to the grave: molecular chaperones that may choose between folding and degradation
J Höhfeld, DM Cyr, C Patterson
EMBO reports 2 (10), 885-890, 2001
Protein quality control: U-box-containing E3 ubiquitin ligases join the fold
DM Cyr, J Höhfeld, C Patterson
Trends in biochemical sciences 27 (7), 368-375, 2002
The Hdj‐2/Hsc70 chaperone pair facilitates early steps in CFTR biogenesis
GC Meacham, Z Lu, S King, E Sorscher, A Tousson, DM Cyr
The EMBO journal 18 (6), 1492-1505, 1999
Mechanisms for regulation of Hsp70 function by Hsp40
CY Fan, S Lee, DM Cyr
Cell stress & chaperones 8 (4), 309, 2003
CHIP-mediated stress recovery by sequential ubiquitination of substrates and Hsp70
SB Qian, H McDonough, F Boellmann, DM Cyr, C Patterson
Nature 440 (7083), 551-555, 2006
YDJ1p facilitates polypeptide translocation across different intracellular membranes by a conserved mechanism
AJ Caplan, DM Cyr, MG Douglas
Cell 71 (7), 1143-1155, 1992
CHIP activates HSF1 and confers protection against apoptosis and cellular stress
Q Dai, C Zhang, Y Wu, H McDonough, RA Whaley, V Godfrey, HH Li, ...
The EMBO journal 22 (20), 5446-5458, 2003
The role of Hsp70 in conferring unidirectionality on protein translocation into mitochondria
C Ungermann, W Neupert, DM Cyr
Science 266 (5188), 1250-1253, 1994
Regulation of Hsp70 function by a eukaryotic DnaJ homolog.
DM Cyr, X Lu, MG Douglas
Journal of Biological Chemistry 267 (29), 20927-20931, 1992
From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations
G Veit, RG Avramescu, AN Chiang, SA Houck, Z Cai, KW Peters, JS Hong, ...
Molecular biology of the cell 27 (3), 424-433, 2016
Eukaryotic homologues of Escherichia coli dnaJ: a diverse protein family that functions with hsp70 stress proteins.
AJ Caplan, DM Cyr, MG Douglas
Molecular biology of the cell 4 (6), 555-563, 1993
Protein folding activity of Hsp70 is modified differentially by the hsp40 co-chaperones Sis1 and Ydj1
Z Lu, DM Cyr
Journal of Biological Chemistry 273 (43), 27824-27830, 1998
Mitochondrial molecular chaperones: their role in protein translocation
RA Stuart, DM Cyr, EA Craig, W Neupert
Trends in biochemical sciences 19 (2), 87-92, 1994
VX-809 corrects folding defects in cystic fibrosis transmembrane conductance regulator protein through action on membrane-spanning domain 1
HY Ren, DE Grove, O De La Rosa, SA Houck, P Sopha, F Van Goor, ...
Molecular biology of the cell 24 (19), 3016-3024, 2013
Gp78 cooperates with RMA1 in endoplasmic reticulum-associated degradation of CFTRΔF508
D Morito, K Hirao, Y Oda, N Hosokawa, F Tokunaga, DM Cyr, K Tanaka, ...
Molecular biology of the cell 19 (4), 1328-1336, 2008
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