Isabella Derler
Isabella Derler
Biophysik, Universitšt Linz
Geverifieerd e-mailadres voor jku.at
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Dynamic coupling of the putative coiled-coil domain of ORAI1 with STIM1 mediates ORAI1 channel activation
M Muik, I Frischauf, I Derler, M Fahrner, J Bergsmann, P Eder, R Schindl, ...
Journal of Biological Chemistry 283 (12), 8014-8022, 2008
4162008
A cytosolic homomerization and a modulatory domain within STIM1 C terminus determine coupling to ORAI1 channels
M Muik, M Fahrner, I Derler, R Schindl, J Bergsmann, I Frischauf, ...
Journal of biological chemistry 284 (13), 8421-8426, 2009
3342009
STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation
M Muik, M Fahrner, R Schindl, P Stathopulos, I Frischauf, I Derler, P Plenk, ...
The EMBO journal 30 (9), 1678-1689, 2011
2272011
TRPC3 and TRPC4 associate to form a redox-sensitive cation channel: evidence for expression of native TRPC3-TRPC4 heteromeric channels in endothelial cells
M Poteser, A Graziani, C Rosker, P Eder, I Derler, H Kahr, MX Zhu, ...
Journal of Biological Chemistry 281 (19), 13588-13595, 2006
2082006
Molecular determinants of the coupling between STIM1 and Orai channels: differential activation of Orai1–3 channels by a STIM1 coiled-coil mutant
I Frischauf, M Muik, I Derler, J Bergsmann, M Fahrner, R Schindl, ...
Journal of biological chemistry 284 (32), 21696-21706, 2009
1532009
2-aminoethoxydiphenyl borate alters selectivity of Orai3 channels by increasing their pore size
R Schindl, J Bergsmann, I Frischauf, I Derler, M Fahrner, M Muik, R Fritsch, ...
Journal of Biological Chemistry 283 (29), 20261-20267, 2008
1432008
The STIM/Orai coupling machinery
I Frischauf, R Schindl, I Derler, J Bergsmann, M Fahrner, C Romanin
Channels 2 (4), 261-268, 2008
1352008
Novel pyrazole compounds for pharmacological discrimination between receptor‐operated and store‐operated Ca2+ entry pathways
H Schleifer, B Doleschal, M Lichtenegger, R Oppenrieder, I Derler, ...
British journal of pharmacology 167 (8), 1712-1722, 2012
1342012
A Ca2+ release-activated Ca2+ (CRAC) modulatory domain (CMD) within STIM1 mediates fast Ca2+-dependent inactivation of ORAI1 channels
I Derler, M Fahrner, M Muik, B Lackner, R Schindl, K Groschner, ...
Journal of biological chemistry 284 (37), 24933-24938, 2009
1312009
Mechanistic view on domains mediating STIM1–Orai coupling
M Fahrner, M Muik, I Derler, R Schindl, R Fritsch, I Frischauf, C Romanin
Immunological reviews 231 (1), 99-112, 2009
1122009
The action of selective CRAC channel blockers is affected by the Orai pore geometry
I Derler, R Schindl, R Fritsch, P Heftberger, MC Riedl, M Begg, D House, ...
Cell calcium 53 (2), 139-151, 2013
1072013
Resting state Orai1 diffuses as homotetramer in the plasma membrane of live mammalian cells
J Madl, J Weghuber, R Fritsch, I Derler, M Fahrner, I Frischauf, B Lackner, ...
Journal of Biological Chemistry 285 (52), 41135-41142, 2010
1022010
Dynamic but not constitutive association of calmodulin with rat TRPV6 channels enables fine tuning of Ca2+‐dependent inactivation
I Derler, M Hofbauer, H Kahr, R Fritsch, M Muik, K Kepplinger, ME Hack, ...
The Journal of physiology 577 (1), 31-44, 2006
982006
Molecular mechanisms of STIM/Orai communication
I Derler, I Jardin, C Romanin
American Journal of Physiology-Cell Physiology 310 (8), C643-C662, 2016
972016
The extended transmembrane Orai1 N-terminal (ETON) region combines binding interface and gate for Orai1 activation by STIM1
I Derler, P Plenk, M Fahrner, M Muik, I Jardin, R Schindl, HJ Gruber, ...
Journal of Biological Chemistry 288 (40), 29025-29034, 2013
952013
Increased hydrophobicity at the N terminus/membrane interface impairs gating of the severe combined immunodeficiency-related ORAI1 mutant
I Derler, M Fahrner, O Carugo, M Muik, J Bergsmann, R Schindl, ...
Journal of Biological Chemistry 284 (23), 15903-15915, 2009
802009
Cholesterol modulates Orai1 channel function
I Derler, I Jardin, PB Stathopulos, M Muik, M Fahrner, V Zayats, ...
Science signaling 9 (412), ra10-ra10, 2016
742016
Plasticity in Ca2+ selectivity of Orai1/Orai3 heteromeric channel
R Schindl, I Frischauf, J Bergsmann, M Muik, I Derler, B Lackner, ...
Proceedings of the National Academy of Sciences 106 (46), 19623-19628, 2009
722009
The STIM1/Orai signaling machinery
M Fahrner, I Derler, I Jardin, C Romanin
Channels 7 (5), 330-343, 2013
582013
A calcium-accumulating region, CAR, in the channel Orai1 enhances Ca2+ permeation and SOCE-induced gene transcription
I Frischauf, V Zayats, M Deix, A Hochreiter, I Jardin, M Muik, B Lackner, ...
Science signaling 8 (408), ra131-ra131, 2015
542015
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Artikelen 1–20