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TinaMarie Lieu
TinaMarie Lieu
Medical Director, Sage Therapeutics
Verified email at sagerx.com
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Cited by
Cited by
Year
The TGR5 receptor mediates bile acid–induced itch and analgesia
F Alemi, E Kwon, DP Poole, TM Lieu, V Lyo, F Cattaruzza, F Cevikbas, ...
The Journal of clinical investigation 123 (4), 1513-1530, 2013
3932013
The bile acid receptor TGR5 activates the TRPA1 channel to induce itch in mice
TM Lieu, G Jayaweera, P Zhao, DP Poole, D Jensen, M Grace, P McIntyre, ...
Gastroenterology 147 (6), 1417-1428, 2014
2262014
Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief
DD Jensen, TM Lieu, ML Halls, NA Veldhuis, WL Imlach, QN Mai, ...
Science Translational Medicine 9 (392), eaal3447, 2017
1922017
Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4
P Zhao, TM Lieu, N Barlow, M Metcalf, NA Veldhuis, DD Jensen, M Kocan, ...
Journal of Biological Chemistry 289 (39), 27215-27234, 2014
1822014
G protein-coupled receptors: dynamic machines for signaling pain and itch
P Geppetti, NA Veldhuis, TM Lieu, NW Bunnett
Neuron 88 (4), 635-649, 2015
1712015
Neutrophil elastase activates protease-activated receptor-2 (PAR2) and transient receptor potential vanilloid 4 (TRPV4) to cause inflammation and pain
P Zhao, TM Lieu, N Barlow, S Sostegni, S Haerteis, C Korbmacher, ...
Journal of Biological Chemistry 290 (22), 13875-13887, 2015
1662015
Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling
DP Poole, S Amadesi, NA Veldhuis, FC Abogadie, TM Lieu, W Darby, ...
Journal of biological chemistry 288 (8), 5790-5802, 2013
1662013
Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission
RE Yarwood, WL Imlach, TM Lieu, NA Veldhuis, DD Jensen, ...
Proceedings of the National Academy of Sciences 114 (46), 12309-12314, 2017
1542017
Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome
NN Jimenez-Vargas, LA Pattison, P Zhao, TM Lieu, R Latorre, DD Jensen, ...
Proceedings of the National Academy of Sciences 115 (31), E7438-E7447, 2018
1502018
Prognostic and mechanistic potential of progesterone sulfates in intrahepatic cholestasis of pregnancy and pruritus gravidarum
S Abu‐Hayyeh, C Ovadia, TM Lieu, DD Jensen, J Chambers, PH Dixon, ...
Hepatology 63 (4), 1287-1298, 2016
1452016
TRPV1 induction in airway vagal low-threshold mechanosensory neurons by allergen challenge and neurotrophic factors
TM Lieu, AC Myers, S Meeker, BJ Undem
American Journal of Physiology-Lung Cellular and Molecular Physiology 302 (9 …, 2012
1292012
A pH-responsive nanoparticle targets the neurokinin 1 receptor in endosomes to prevent chronic pain
PD Ramírez-García, JS Retamal, P Shenoy, W Imlach, M Sykes, N Truong, ...
Nature Nanotechnology 14 (12), 1150-1159, 2019
1152019
Role of TGR5 (GPBAR1) in liver disease
V Keitel, D Häussinger
Seminars in liver disease 38 (04), 333-339, 2018
842018
Activation of pruritogenic TGR5, MrgprA3, and MrgprC11 on colon-innervating afferents induces visceral hypersensitivity
J Castro, AM Harrington, TM Lieu, S Garcia-Caraballo, J Maddern, ...
JCI insight 4 (20), 2019
682019
Neurotrophin and GDNF family ligand receptor expression in vagal sensory nerve subtypes innervating the adult guinea pig respiratory tract
TM Lieu, M Kollarik, AC Myers, BJ Undem
American Journal of Physiology-Lung Cellular and Molecular Physiology 300 (5 …, 2011
582011
GPBA: a GPCR for bile acids and an emerging therapeutic target for disorders of digestion and sensation
T Lieu, G Jayaweera, NW Bunnett
British journal of pharmacology 171 (5), 1156-1166, 2014
552014
The tyrosine kinase inhibitor bafetinib inhibits PAR2‐induced activation of TRPV4 channels in vitro and pain in vivo
MS Grace, T Lieu, B Darby, FC Abogadie, N Veldhuis, NW Bunnett, ...
British journal of pharmacology 171 (16), 3881-3894, 2014
542014
Parainfluenza 3-Induced Cough Hypersensitivity in the Guinea Pig Airways
BJU Eric J. Zaccone , TinaMarie Lieu , Yukiko Muroi , Carl Potenzieri ...
Plos One, 2016
532016
Effects of food components that activate TRPA1 receptors on mucosal ion transport in the mouse intestine
LJ Fothergill, B Callaghan, LR Rivera, TM Lieu, DP Poole, HJ Cho, ...
Nutrients 8 (10), 623, 2016
352016
G-CSF receptor blockade ameliorates arthritic pain and disease
MC Lee, JA McCubbin, AD Christensen, DP Poole, P Rajasekhar, ...
The Journal of Immunology 198 (9), 3565-3575, 2017
332017
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