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Leihong Wu
Leihong Wu
Division of Bioinformatics and Biostatistics, National Center of Toxicological Research, FDA
Geverifieerd e-mailadres voor fda.hhs.gov
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Evaluating the analytical validity of circulating tumor DNA sequencing assays for precision oncology
IW Deveson, B Gong, K Lai, JS LoCoco, TA Richmond, J Schageman, ...
Nature biotechnology 39 (9), 1115-1128, 2021
1472021
A network pharmacology study of Chinese medicine QiShenYiQi to reveal its underlying multi-compound, multi-target, multi-pathway mode of action
X Li, L Wu, W Liu, Y Jin, Q Chen, L Wang, X Fan, Z Li, Y Cheng
PloS one 9 (5), e95004, 2014
1322014
Comparing SVM and ANN based machine learning methods for species identification of food contaminating beetles
H Bisgin, T Bera, H Ding, HG Semey, L Wu, Z Liu, AE Barnes, DA Langley, ...
Scientific reports 8 (1), 6532, 2018
1132018
Drug-induced liver injury severity and toxicity (DILIst): binary classification of 1279 drugs by human hepatotoxicity
S Thakkar, T Li, Z Liu, L Wu, R Roberts, W Tong
Drug discovery today 25 (1), 201-208, 2020
792020
Toward best practice in cancer mutation detection with whole-genome and whole-exome sequencing
W Xiao, L Ren, Z Chen, LT Fang, Y Zhao, J Lack, M Guan, B Zhu, ...
Nature biotechnology 39 (9), 1141-1150, 2021
782021
Identifying roles of “Jun-Chen-Zuo-Shi” component herbs of QiShenYiQi formula in treating acute myocardial ischemia by network pharmacology
L Wu, Y Wang, Z Li, B Zhang, Y Cheng, X Fan
Chinese medicine 9, 1-9, 2014
602014
Comprehensive assessments of RNA-seq by the SEQC consortium: FDA-led efforts advance precision medicine
J Xu, B Gong, L Wu, S Thakkar, H Hong, W Tong
Pharmaceutics 8 (1), 8, 2016
572016
Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans
D Yu, L Wu, P Gill, WH Tolleson, S Chen, J Sun, B Knox, Y Jin, W Xiao, ...
Archives of toxicology 92, 845-858, 2018
532018
A network pharmacology approach to evaluating the efficacy of Chinese medicine using genome-wide transcriptional expression data
L Wu, Y Wang, J Nie, X Fan, Y Cheng
Evidence-Based Complementary and Alternative Medicine 2013, 2013
532013
Identification of the effective constituents for anti-inflammatory activity of Ju-Zhi-Jiang-Tang, an ancient traditional Chinese medicine formula
S Wang, P Chen, W Jiang, L Wu, L Chen, X Fan, Y Wang, Y Cheng
Journal of Chromatography a 1348, 105-124, 2014
482014
Study of serious adverse drug reactions using FDA-approved drug labeling and MedDRA
L Wu, T Ingle, Z Liu, A Zhao-Wong, S Harris, S Thakkar, G Zhou, J Yang, ...
BMC bioinformatics 20, 129-139, 2019
412019
Relating anatomical therapeutic indications by the ensemble similarity of drug sets
L Wu, N Ai, Y Liu, Y Wang, X Fan
Journal of chemical information and modeling 53 (8), 2154-2160, 2013
402013
Fabry’s disease and stroke: Effectiveness of enzyme replacement therapy (ERT) in stroke prevention, a review with meta-analysis
S Sheng, L Wu, K Nalleballe, R Sharma, A Brown, S Ranabothu, ...
Journal of Clinical Neuroscience 65, 83-86, 2019
392019
A deep learning model to recognize food contaminating beetle species based on elytra fragments
L Wu, Z Liu, T Bera, H Ding, DA Langley, A Jenkins-Barnes, C Furlanello, ...
Computers and Electronics in Agriculture 166, 105002, 2019
382019
Trade-off predictivity and explainability for machine-learning powered predictive toxicology: An in-depth investigation with Tox21 data sets
L Wu, R Huang, IV Tetko, Z Xia, J Xu, W Tong
Chemical research in toxicology 34 (2), 541-549, 2021
352021
Toxicogenomic analysis of the particle dose-and size-response relationship of silica particles-induced toxicity in mice
X Lu, T Jin, Y Jin, L Wu, B Hu, Y Tian, X Fan
Nanotechnology 24 (1), 015106, 2012
312012
A verified genomic reference sample for assessing performance of cancer panels detecting small variants of low allele frequency
W Jones, B Gong, N Novoradovskaya, D Li, R Kusko, TA Richmond, ...
Genome biology 22, 1-38, 2021
282021
Network pharmacology study on major active compounds of Fufang Danshen formula
X Li, L Wu, X Fan, B Zhang, X Gao, Y Wang, Y Cheng
Zhongguo Zhong yao za zhi= Zhongguo Zhongyao Zazhi= China Journal of Chinese …, 2011
282011
Integrating drug’s mode of action into quantitative structure–activity relationships for improved prediction of drug-induced liver injury
L Wu, Z Liu, S Auerbach, R Huang, M Chen, K McEuen, J Xu, H Fang, ...
Journal of chemical information and modeling 57 (4), 1000-1006, 2017
262017
NGS evaluation of colorectal cancer reveals interferon gamma dependent expression of immune checkpoint genes and identification of novel IFNγ induced genes
L Xu, L Pelosof, R Wang, HI McFarland, JN Phue, LH Wu, WL Alterovitz, ...
Frontiers in immunology 11, 507482, 2020
232020
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Artikelen 1–20