Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach MH Wright, B Clough, MD Rackham, K Rangachari, JA Brannigan, ... Nature chemistry 6 (2), 112-121, 2014 | 214 | 2014 |
Extended pharmacodynamic responses observed upon PROTAC-mediated degradation of RIPK2 A Mares, AH Miah, IED Smith, M Rackham, AR Thawani, J Cryan, ... Communications biology 3 (1), 140, 2020 | 147 | 2020 |
A caged E3 ligase ligand for PROTAC-mediated protein degradation with light CS Kounde, MM Shchepinova, CN Saunders, M Muelbaier, MD Rackham, ... Chemical communications 56 (41), 5532-5535, 2020 | 89 | 2020 |
N-Myristoyltransferase as a potential drug target in malaria and leishmaniasis EW Tate, AS Bell, MD Rackham, MH Wright Parasitology 141 (1), 37-49, 2014 | 78 | 2014 |
Design and Synthesis of High Affinity Inhibitors of Plasmodium falciparum and Plasmodium vivax N-Myristoyltransferases Directed by Ligand Efficiency Dependent … MD Rackham, JA Brannigan, K Rangachari, S Meister, AJ Wilkinson, ... Journal of Medicinal Chemistry 57 (6), 2773-2788, 2014 | 75 | 2014 |
Discovery of Novel and Ligand-Efficient Inhibitors of Plasmodium falciparum and Plasmodium vivaxN-Myristoyltransferase MD Rackham, JA Brannigan, DK Moss, Z Yu, AJ Wilkinson, AA Holder, ... Journal of Medicinal Chemistry 56 (1), 371-375, 2013 | 73 | 2013 |
Optimization of a series of RIPK2 PROTACs AH Miah, IED Smith, M Rackham, A Mares, AR Thawani, R Nagilla, ... Journal of Medicinal Chemistry 64 (17), 12978-13003, 2021 | 33 | 2021 |
Discovery of high affinity inhibitors of Leishmania donovani N-myristoyltransferase MD Rackham, Z Yu, JA Brannigan, WP Heal, D Paape, KV Barker, ... MedChemComm 6 (10), 1761-1766, 2015 | 33 | 2015 |
Compounds LN Casillas, JD Harling, AH Miah, MD Rackham, IED Smith US Patent 10,435,391, 2019 | 7 | 2019 |
Conjugates comprising RIPK2 inhibitors LN Casillas, JD Harling, AH Miah, MD Rackham, IED Smith US Patent 10,781,205, 2020 | 4 | 2020 |
Novel compounds and their use in therapy R Leatherbarrow, E Tate, Z Yu, M Racklam London Patent WO 83991, 13, 2013 | 4 | 2013 |
The medicinal chemistry of mitochondrial dysfunction: a critical overview of efforts to modulate mitochondrial health MTW Lee, W Mahy, MD Rackham RSC Medicinal Chemistry 12 (8), 1281-1311, 2021 | 1 | 2021 |
Conjugates comprising ripk2 inhibitors LN Casillas, JD Harling, AH MIAH, IED Smith, MD RACKHAM | 1 | 2017 |
Novel compounds LN Casillas, JD Harling, AH Miah, MD Rackham, IED Smith US Patent App. 16/547,734, 2019 | | 2019 |
Conjugates comprising ripk2 inhibitors LN Casillas, JD Harling, AH MIAH, IED Smith, MD RACKHAM | | 2019 |
Design and synthesis of N-Myristoyltransferase inhibitors: a promising treatment for malaria M Rackham Imperial College London, 2012 | | 2012 |