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Ligong Chen
Ligong Chen
Professor of Pharmacology, Tsinghua University
Verified email at tsinghua.edu.cn
Title
Cited by
Cited by
Year
A network integration approach for drug-target interaction prediction and computational drug repositioning from heterogeneous information
Y Luo, X Zhao, J Zhou, J Yang, Y Zhang, W Kuang, J Peng, L Chen, ...
Nature communications 8 (1), 573, 2017
6492017
Apolipoprotein E4 causes age-and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice
Y Andrews-Zwilling, N Bien-Ly, Q Xu, G Li, A Bernardo, SY Yoon, ...
Journal of Neuroscience 30 (41), 13707-13717, 2010
3532010
A deep learning framework for modeling structural features of RNA-binding protein targets
S Zhang, J Zhou, H Hu, H Gong, L Chen, C Cheng, J Zeng
Nucleic acids research 44 (4), e32-e32, 2016
2892016
Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin
Y Chen, S Li, C Brown, S Cheatham, RA Castro, MK Leabman, TJ Urban, ...
Pharmacogenetics and genomics 19 (7), 497-504, 2009
2822009
Role of organic cation transporter 3 (SLC22A3) and its missense variants in the pharmacologic action of metformin
L Chen, B Pawlikowski, A Schlessinger, SS More, D Stryke, SJ Johns, ...
Pharmacogenetics and genomics 20 (11), 687-699, 2010
2442010
An integrative drug repositioning framework discovered a potential therapeutic agent targeting COVID-19
Y Ge, T Tian, S Huang, F Wan, J Li, S Li, X Wang, H Yang, L Hong, N Wu, ...
Signal transduction and targeted therapy 6 (1), 165, 2021
2362021
OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin
L Chen, Y Shu, X Liang, EC Chen, SW Yee, AA Zur, S Li, L Xu, ...
Proceedings of the National Academy of Sciences 111 (27), 9983-9988, 2014
2252014
Memory T cells: strategies for optimizing tumor immunotherapy
Q Liu, Z Sun, L Chen
Protein & cell 11 (8), 549-564, 2020
1842020
Structural model for γ-aminobutyric acid receptor noncompetitive antagonist binding: widely diverse structures fit the same site
L Chen, KA Durkin, JE Casida
Proceedings of the National Academy of Sciences 103 (13), 5185-5190, 2006
1802006
The SLC transporter in nutrient and metabolic sensing, regulation, and drug development
Y Zhang, Y Zhang, K Sun, Z Meng, L Chen
Journal of molecular cell biology 11 (1), 1-13, 2019
1712019
Regulation of glucose and lipid metabolism in health and disease
L Chen, XW Chen, X Huang, BL Song, Y Wang, Y Wang
Science China life sciences 62, 1420-1458, 2019
1672019
A functional mammalian target of rapamycin complex 1 signaling is indispensable for c‐Myc‐driven hepatocarcinogenesis
P Liu, M Ge, J Hu, X Li, L Che, K Sun, L Cheng, Y Huang, MG Pilo, ...
Hepatology 66 (1), 167-181, 2017
1522017
Cholesterol biosynthesis supports the growth of hepatocarcinoma lesions depleted of fatty acid synthase in mice and humans
L Che, W Chi, Y Qiao, J Zhang, X Song, Y Liu, L Li, J Jia, MG Pilo, J Wang, ...
Gut 69 (1), 177-186, 2020
1412020
Solute carrier transporters: the metabolic gatekeepers of immune cells
W Song, D Li, L Tao, Q Luo, L Chen
Acta Pharmaceutica Sinica B 10 (1), 61-78, 2020
1362020
Slc6a8-mediated creatine uptake and accumulation reprogram macrophage polarization via regulating cytokine responses
L Ji, X Zhao, B Zhang, L Kang, W Song, B Zhao, W Xie, L Chen, X Hu
Immunity 51 (2), 272-284. e7, 2019
1282019
The physiological role of drug transporters
Y Liang, S Li, L Chen
Protein & cell 6 (5), 334-350, 2015
1282015
Targeted disruption of organic cation transporter 3 attenuates the pharmacologic response to metformin
EC Chen, X Liang, SW Yee, EG Geier, SL Stocker, L Chen, KM Giacomini
Molecular pharmacology 88 (1), 75-83, 2015
1132015
The solute carrier transporters and the brain: Physiological and pharmacological implications
C Hu, L Tao, X Cao, L Chen
Asian journal of pharmaceutical sciences 15 (2), 131-144, 2020
1122020
Genetic polymorphisms in organic cation transporter 1 (OCT1) in Chinese and Japanese populations exhibit altered function
L Chen, M Takizawa, E Chen, A Schlessinger, J Segenthelar, JH Choi, ...
Journal of Pharmacology and Experimental Therapeutics 335 (1), 42-50, 2010
1092010
Genotype-dependent effects of inhibitors of the organic cation transporter, OCT1: predictions of metformin interactions
G Ahlin, L Chen, L Lazorova, Y Chen, AG Ianculescu, RL Davis, ...
The pharmacogenomics journal 11 (6), 400-411, 2011
1042011
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