| Solution structure and basis for functional activity of stromal cell‐derived factor‐1; dissociation of CXCR4 activation from binding and inhibition of HIV‐1 MP Crump, JH Gong, P Loetscher, K Rajarathnam, A Amara, ... The EMBO journal, 1997 | 965 | 1997 |
| Structure‐activity relationships of chemokines I Clark‐Lewis, KS Kim, K Rajarathnam, JH Gong, B Dewald, B Moser, ... Journal of leukocyte biology 57 (5), 703-711, 1995 | 526 | 1995 |
| Neutrophil activation by monomeric interleukin-8 K Rajarathnam, B Sykes, C Kay, B Dewald, T Geiser, M Baggiolini, ... Science 264, 90-92, 1994 | 414 | 1994 |
| 13C NMR chemical shifts can predict disulfide bond formation D Sharma, K Rajarathnam Journal of biomolecular NMR 18, 165-171, 2000 | 342 | 2000 |
| Chemokine CXCL1 mediated neutrophil recruitment: Role of glycosaminoglycan interactions KV Sawant, KM Poluri, AK Dutta, KM Sepuru, A Troshkina, RP Garofalo, ... Scientific reports 6 (1), 33123, 2016 | 308 | 2016 |
| The purified myxoma virus gamma interferon receptor homolog M-T7 interacts with the heparin-binding domains of chemokines AS Lalani, K Graham, K Mossman, K Rajarathnam, I Clark-Lewis, ... Journal of virology 71 (6), 4356-4363, 1997 | 226 | 1997 |
| Differential activation and regulation of CXCR1 and CXCR2 by CXCL8 monomer and dimer MW Nasser, SK Raghuwanshi, DJ Grant, VR Jala, K Rajarathnam, ... The Journal of Immunology 183 (5), 3425-3432, 2009 | 215 | 2009 |
| Structural basis of chemokine receptor function—a model for binding affinity and ligand selectivity L Rajagopalan, K Rajarathnam Bioscience reports 26 (5), 325-339, 2006 | 192 | 2006 |
| How do chemokines navigate neutrophils to the target site: Dissecting the structural mechanisms and signaling pathways K Rajarathnam, M Schnoor, RM Richardson, S Rajagopal Cellular signalling 54, 69-80, 2019 | 186 | 2019 |
| Solution structure of eotaxin, a chemokine that selectively recruits eosinophils in allergic inflammation MP Crump, K Rajarathnam, KS Kim, I Clark-Lewis, BD Sykes Journal of Biological Chemistry 273 (35), 22471-22479, 1998 | 152 | 1998 |
| Monomeric and dimeric CXCL8 are both essential for in vivo neutrophil recruitment ST Das, L Rajagopalan, A Guerrero-Plata, J Sai, A Richmond, ... PloS one 5 (7), e11754, 2010 | 139 | 2010 |
| Ligand selectivity and affinity of chemokine receptor CXCR1: role of N-terminal domain L Rajagopalan, K Rajarathnam Journal of Biological Chemistry 279 (29), 30000-30008, 2004 | 139 | 2004 |
| Isothermal titration calorimetry of membrane proteins—Progress and challenges K Rajarathnam, J Rösgen Biochimica et Biophysica Acta (BBA)-Biomembranes 1838 (1), 69-77, 2014 | 136 | 2014 |
| Synthesis, location, and lateral mobility of fluorescently labeled ubiquinone 10 in mitochondrial and artificial membranes K Rajarathnam, J Hochman, M Schindler, S Ferguson-Miller Biochemistry 28 (8), 3168-3176, 1989 | 133 | 1989 |
| 1H NMR solution structure of an active monomeric interleukin-8 K Rajarathnam, I Clark-Lewis, BD Sykes Biochemistry 34 (40), 12983-12990, 1995 | 123 | 1995 |
| Structural characterization of a monomeric chemokine: Monocyte chemoattractant protein‐3 KS Kim, K Rajarathnam, I Clark-Lewis, BD Sykes FEBS letters 395 (2-3), 277-282, 1996 | 111 | 1996 |
| Chemokine CXCL1-mediated neutrophil trafficking in the lung: role of CXCR2 activation KV Sawant, R Xu, R Cox, H Hawkins, E Sbrana, D Kolli, RP Garofalo, ... Journal of innate immunity 7 (6), 647-658, 2015 | 110 | 2015 |
| Solution NMR characterization of chemokine CXCL8/IL-8 monomer and dimer binding to glycosaminoglycans: structural plasticity mediates differential binding interactions PRB Joseph, PD Mosier, UR Desai, K Rajarathnam Biochemical Journal 472 (1), 121-133, 2015 | 104 | 2015 |
| Dimer dissociation is essential for interleukin-8 (IL-8) binding to CXCR1 receptor H Fernando, C Chin, J Rösgen, K Rajarathnam Journal of Biological Chemistry 279 (35), 36175-36178, 2004 | 104 | 2004 |
| Disulfide bridges in interleukin-8 probed using non-natural disulfide analogues: dissociation of roles in structure from function K Rajarathnam, BD Sykes, B Dewald, M Baggiolini, I Clark-Lewis Biochemistry 38 (24), 7653-7658, 1999 | 99 | 1999 |
Umesh DesaiProfessor of Medicinal Chemistry, Virginia Commonwealth UniversityVerified email at vcu.edu
