| Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice K Hsiao, P Chapman, S Nilsen, C Eckman, Y Harigaya, S Younkin, ... Science 274 (5284), 99-103, 1996 | 5394 | 1996 |
| Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease JC Lambert, CA Ibrahim-Verbaas, D Harold, AC Naj, R Sims, ... Nature genetics 45 (12), 1452-1458, 2013 | 4344 | 2013 |
| Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to … D Scheuner, C Eckman, M Jensen, X Song, M Citron, N Suzuki, TD Bird, ... Nature medicine 2 (8), 864-870, 1996 | 3560 | 1996 |
| Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease D Harold, R Abraham, P Hollingworth, R Sims, A Gerrish, ML Hamshere, ... Nature genetics 41 (10), 1088-1093, 2009 | 3291 | 2009 |
| TREM2 Variants in Alzheimer's Disease R Guerreiro, A Wojtas, J Bras, M Carrasquillo, E Rogaeva, E Majounie, ... New England Journal of Medicine 368 (2), 117-127, 2013 | 3061 | 2013 |
| An Increased Percentage of Long Amyloid β Protein Secreted by Familial Amyloid β Protein Precursor (βApp717) Mutants N Suzuki, TT Cheung, XD Cai, A Odaka, L Otvos Jr, C Eckman, TE Golde, ... Science 264 (5163), 1336-1340, 1994 | 2221 | 1994 |
| Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing BW Kunkle, B Grenier-Boley, R Sims, JC Bis, V Damotte, AC Naj, ... Nature genetics 51 (3), 414-430, 2019 | 2175 | 2019 |
| Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease P Hollingworth, D Harold, R Sims, A Gerrish, JC Lambert, ... Nature genetics 43 (5), 429-435, 2011 | 2154 | 2011 |
| Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease AC Naj, G Jun, GW Beecham, LS Wang, BN Vardarajan, J Buros, ... Nature genetics 43 (5), 436-441, 2011 | 2138 | 2011 |
| Familial Alzheimer's disease–linked presenilin 1 variants elevate Aβ1–42/1–40 ratio in vitro and in vivo DR Borchelt, G Thinakaran, CB Eckman, MK Lee, F Davenport, ... Neuron 17 (5), 1005-1013, 1996 | 2087 | 1996 |
| Increased amyloid-β42 (43) in brains of mice expressing mutant presenilin 1 K Duff, C Eckman, C Zehr, X Yu, CM Prada, J Perez-Tur, M Hutton, L Buee, ... Nature 383 (6602), 710-713, 1996 | 2043 | 1996 |
| Production of the Alzheimer amyloid β protein by normal proteolytic processing M Shoji, TE Golde, J Ghiso, TT Cheung, S Estus, LM Shaffer, XD Cai, ... Science 258 (5079), 126-129, 1992 | 1974 | 1992 |
| Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo: evidence for augmentation of a 42-specific γ secretase JL Jankowsky, DJ Fadale, J Anderson, GM Xu, V Gonzales, NA Jenkins, ... Human molecular genetics 13 (2), 159-170, 2004 | 1728 | 2004 |
| The'Arctic'APP mutation (E693G) causes Alzheimer's disease by enhanced Aβ protofibril formation C Nilsberth, A Westlind-Danielsson, CB Eckman, MM Condron, ... Nature neuroscience 4 (9), 887-893, 2001 | 1509 | 2001 |
| Release of excess amyloid β protein from a mutant amyloid β protein precursor XD Cai, TE Golde, SG Younkin Science 259 (5094), 514-516, 1993 | 1479 | 1993 |
| The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease E Rogaeva, Y Meng, JH Lee, Y Gu, T Kawarai, F Zou, T Katayama, ... Nature genetics 39 (2), 168-177, 2007 | 1402 | 2007 |
| Age-dependent changes in brain, CSF, and plasma amyloid β protein in the Tg2576 transgenic mouse model of Alzheimer's disease T Kawarabayashi, LH Younkin, TC Saido, M Shoji, KH Ashe, SG Younkin Journal of neuroscience 21 (2), 372-381, 2001 | 1277 | 2001 |
| Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice PF Chapman, GL White, MW Jones, D Cooper-Blacketer, VJ Marshall, ... Nature neuroscience 2 (3), 271-276, 1999 | 1176 | 1999 |
| Processing of the amyloid protein precursor to potentially amyloidogenic derivatives TE Golde, S Estus, LH Younkin, DJ Selkoe, SG Younkin Science 255 (5045), 728-730, 1992 | 956 | 1992 |
| The relationship between Aβ and memory in the Tg2576 mouse model of Alzheimer's disease MA Westerman, D Cooper-Blacketer, A Mariash, L Kotilinek, ... Journal of neuroscience 22 (5), 1858-1867, 2002 | 918 | 2002 |
