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Wallace KB Chan
Wallace KB Chan
Verified email at pfizer.com
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Year
GLASS: a comprehensive database for experimentally-validated GPCR-ligand associations
WKB Chan, H Zhang, J Yang, JR Brender, J Hur, A Özgür, Y Zhang
Bioinformatics, btv302, 2015
1092015
Targeting acetylcholinesterase to membrane rafts: a function mediated by the proline-rich membrane anchor (PRiMA) in neurons
HQ Xie, D Liang, KW Leung, VP Chen, KY Zhu, WKB Chan, RCY Choi, ...
Journal of biological chemistry 285 (15), 11537-11546, 2010
622010
The assembly of proline-rich membrane anchor (PRiMA)-linked acetylcholinesterase enzyme: glycosylation is required for enzymatic activity but not for oligomerization
VP Chen, RCY Choi, WKB Chan, KW Leung, AJY Guo, GKL Chan, ...
Journal of Biological Chemistry 286 (38), 32948-32961, 2011
442011
WDL-RF: predicting bioactivities of ligand molecules acting with G protein-coupled receptors by combining weighted deep learning and random forest
J Wu, Q Zhang, W Wu, T Pang, H Hu, WKB Chan, X Ke, Y Zhang
Bioinformatics 34 (13), 2271-2282, 2018
432018
Ontological and bioinformatic analysis of anti-coronavirus drugs and their implication for drug repurposing against COVID-19
Y Liu, W Chan, Z Wang, J Hur, J Xie, H Yu, Y He
MDPI AG, 2020
332020
PRiMA directs a restricted localization of tetrameric AChE at synapses
HQ Xie, KW Leung, VP Chen, GKL Chan, SL Xu, AJY Guo, KY Zhu, ...
Chemico-biological interactions 187 (1-3), 78-83, 2010
312010
Molecular assembly and biosynthesis of acetylcholinesterase in brain and muscle: the roles of t-peptide, FHB domain, and N-linked glycosylation
VP Chen, WKW Luk, WKB Chan, KW Leung, AJY Guo, GKL Chan, SL Xu, ...
Frontiers in molecular neuroscience 4, 36, 2011
302011
The PRiMA-linked cholinesterase tetramers are assembled from homodimers: hybrid molecules composed of acetylcholinesterase and butyrylcholinesterase dimers are up-regulated …
VP Chen, HQ Xie, WKB Chan, KW Leung, GKL Chan, RCY Choi, S Bon, ...
Journal of biological chemistry 285 (35), 27265-27278, 2010
302010
The genetic heterogeneity and drug resistance mechanisms of relapsed refractory multiple myeloma
JN Vo, YM Wu, J Mishler, S Hall, R Mannan, L Wang, Y Ning, J Zhou, ...
Nature communications 13 (1), 3750, 2022
262022
Ontological modeling and analysis of experimentally or clinically verified drugs against coronavirus infection
YH Yingtong Liu, Junguk Hur, Wallace K. B. Chan, Zhigang Wang, Jiangan Xie ...
Scientific Data 8 (16), 2021
212021
Virtual Screening of Human Class-A GPCRs Using Ligand Profiles Built on Multiple Ligand–Receptor Interactions
WKB Chan, Y Zhang
Journal of molecular biology 432 (17), 4872-4890, 2020
212020
In silico analysis of SARS-CoV-2 proteins as targets for clinically available drugs
WKB Chan, KM Olson, JW Wotring, JZ Sexton, HA Carlson, JR Traynor
Scientific Reports 12 (1), 5320, 2022
192022
Precise modelling and interpretation of bioactivities of ligands targeting G protein-coupled receptors
J Wu, B Liu, WKB Chan, W Wu, T Pang, H Hu, S Yan, X Ke, Y Zhang
Bioinformatics 35 (14), i324-i332, 2019
162019
Computational identification of possible allosteric sites and modulators of the SARS-CoV-2 main protease
D DasGupta, WKB Chan, HA Carlson
Journal of chemical information and modeling 62 (3), 618-626, 2022
92022
Homologous G protein-coupled receptors boost the modeling and interpretation of bioactivities of ligand molecules
J Wu, Y Sun, WKB Chan, Y Zhu, W Zhu, W Huang, H Hu, S Yan, T Pang, ...
Journal of chemical information and modeling 60 (3), 1865-1875, 2020
92020
Mixed‐solvent molecular dynamics simulation‐based discovery of a putative allosteric site on regulator of G protein signaling 4
WKB Chan, D DasGupta, HA Carlson, JR Traynor
Journal of computational chemistry 42 (30), 2170-2180, 2021
72021
N-linked glycosylation of proline-rich membrane anchor (PRiMA) is not required for assembly and trafficking of globular tetrameric acetylcholinesterase
WKB Chan, VP Chen, WKW Luk, RCY Choi, KWK Tsim
Neuroscience Letters 523 (1), 71-75, 2012
62012
An induction effect of heat shock on the transcript of globular acetylcholinesterase in NG108-15 cells
VP Chen, HQ Xie, WKB Chan, KW Leung, RCY Choi, KWK Tsim
Chemico-biological interactions 187 (1-3), 106-109, 2010
42010
Application of Mixed-Solvent Molecular Dynamics Simulations for Prediction of Allosteric Sites on G Protein–Coupled Receptors
WKB Chan, HA Carlson, JR Traynor
Molecular Pharmacology 103 (5), 274-285, 2023
32023
The assembly of PRiMA-linked acetylcholinesterase: glycosylation is required for enzymatic activity but not for oligomerization
VP Chen, RC Choi, WK Chan, KW Leung, AJ Guo, GK Chan, WK Luk, ...
J Biol Chem 286, 32948-32961, 2011
32011
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