Luis Fonseca-Ornelas
Luis Fonseca-Ornelas
Postdoctoral fellow Harvard Medical School
Verified email at bwh.harvard.edu
Title
Cited by
Cited by
Year
The mechanism of sirtuin 2–mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease
RM de Oliveira, H Vicente Miranda, L Francelle, R Pinho, ÉM Szegö, ...
PLoS biology 15 (3), e2000374, 2017
782017
Small molecule-mediated stabilization of vesicle-associated helical α-synuclein inhibits pathogenic misfolding and aggregation
L Fonseca-Ornelas, SE Eisbach, M Paulat, K Giller, CO Fernández, ...
Nature communications 5 (1), 1-11, 2014
632014
Fasudil attenuates aggregation of α-synuclein in models of Parkinson’s disease
L Tatenhorst, K Eckermann, V Dambeck, L Fonseca-Ornelas, H Walle, ...
Acta neuropathologica communications 4 (1), 1-17, 2016
602016
Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity
A Villar-Piqué, TL Da Fonseca, R Sant’Anna, ÉM Szegö, ...
Proceedings of the National Academy of Sciences 113 (42), E6506-E6515, 2016
572016
Nuclear localization and phosphorylation modulate pathological effects of alpha-synuclein
R Pinho, I Paiva, KG Jerčić, L Fonseca-Ornelas, E Gerhardt, C Fahlbusch, ...
Human molecular genetics 28 (1), 31-50, 2019
452019
Refolding of helical soluble α‐synuclein through transient interaction with lipid interfaces
M Rovere, JB Sanderson, L Fonseca‐Ornelas, DS Patel, T Bartels
FEBS letters 592 (9), 1464-1472, 2018
242018
Synphilin suppresses α‐synuclein neurotoxicity in a Parkinson's disease Drosophila model
RH Vargas, LF Ornelas, IL González, JR Escovar, M Zurita, E Reynaud
genesis 49 (5), 392-402, 2011
242011
Burial of the polymorphic residue 129 in amyloid fibrils of prion stop mutants
L Skora, L Fonseca-Ornelas, RV Hofele, D Riedel, K Giller, J Watzlawik, ...
Journal of Biological Chemistry 288 (5), 2994-3002, 2013
152013
E46K-like α-synuclein mutants increase lipid interactions and disrupt membrane selectivity
M Rovere, AE Powers, H Jiang, JC Pitino, L Fonseca-Ornelas, DS Patel, ...
Journal of Biological Chemistry 294 (25), 9799-9812, 2019
142019
Small molecule-induced soluble oligomers of α-synuclein with helical structure.
L Fonseca-Ornelas, CD Schmidt, AR Camacho-Zarco, CO Fernandez, ...
Chemistry. A European Journal 23 (53), 13010-13014, 2017
122017
Small molecule-mediated stabilization of vesicle-associated helical α-synuclein inhibits pathogenic misfolding and aggregation.[Internet]. Nat. Commun 5: 5857
L Fonseca-Ornelas, SE Eisbach, M Paulat, K Giller, CO Fernández, ...
52014
The protonation state of histidine 111 regulates the aggregation of the evolutionary most conserved region of the human prion protein
L Fonseca‐Ornelas, M Zweckstetter
Protein Science 25 (8), 1563-1567, 2016
22016
Deciphering the molecular effects of alpha-synuclein in the nucleus: A new concept in synucleinopathies
R Pinho, L Soreq, H Soreq, L Fonseca, M Zweckstetter, K Gotovac, ...
12014
Reconstitution of Helical Soluble α-Synuclein through Transient Interaction with Lipid Interfaces
M Rovere, JB Sanderson, L Fonseca-Ornelas, T Bartels
bioRxiv, 202994, 2017
2017
Modulating the aggregation of alpha-synuclein and prion protein with small molecules.
L Fonseca-Ornelas
Georg-August-Universität Göttingen, 2016
2016
The Parkinson-Causing LRRK2 Mutation G2019S Impairs the Physiological Tetramerization of Α-Synuclein in Human Neurons
L Fonseca-Ornelas, J Stricker, U Dettmer, C Muratore, D Selkoe
Available at SSRN 3775871, 0
Altered Conformation of α-Synuclein Drives Malfunction of Synaptic Vesicles in a Model of Parkinson's Disease
L Fonseca-Ornelas, T Viennet, M Rovere, H Jiang, L Liu, S Nuber, ...
Available at SSRN 3684858, 0
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Articles 1–17